Comparative Study of Video Endoscopic Inguinal Lymphadenectomy Through a Hypogastric vs Leg Subcutaneous Approach for Penile Cancer

Yuan, Peng; Zhao, Cheng; Liu, Zhizhong; Ou, Zhenyu; He, Wei; Cai, Yuxiang; Wang, Yu; Zu, Xiongbin; Qi, Lin; Wang, Long

doi:10.1089/end.2017.0455

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…Comparing these methods, prophylactic lymphadenectomy has the best overall survival benefit from early resection of occult metastasis 11,12. However, concurrent complications related to lymph drainage and wound healing are relatively high despite surgical modifications 13–15. Therefore, accurate inguinal LNM prediction could pinpoint patients who are the best candidates for inguinal lymphadenectomy, which could not only achieve the best survival rate for patients with occult metastasis but also avoid unnecessary treatment for patients with a low risk of developing LNM.…”

Section: Introductionmentioning

confidence: 99%

Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies

Hu¹,

Liu²,

Ren³

et al. 2019

CMAR

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Purpose Inguinal lymph node metastasis (LNM) is one of the most significant prognostic factors for patients with penile cancer. This study aimed to identify potential predictors of inguinal LNM. Patients and methods A comprehensive search of the PubMed, Embase, and Cochrane Library databases for studies that reported predictors of inguinal LNM in penile cancer was performed. Finally, we selected 42 eligible studies with 4,802 patients. Accumulative analyses of odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were performed. All analyses were performed by using Review Manager software version 5.3. Results Among the 4,802 patients, 1,706 (36%) were diagnosed with inguinal LNM. Predictors of LNM included two categories: tumor-associated biomarkers and invasive clinicopathologic characteristics. Biomarker-specific predictors: the program death ligand 1 (PD-L1) overexpression (OR=2.55, p =0.002), higher neutrophil-to-lymphocyte ratio (NLR) (OR=4.22, p =0.010), higher C-reactive protein (CRP) (OR=4.78, p <0.001), squamous cell carcinoma antigen (SCC-Ag) overexpression (OR=8.52, p <0.001), P53 protein overexpression (OR=3.57, p <0.001). Clinicopathological predictors: positive clinical lymph node (cN+) (OR=5.86, p <0.001), high-risk histopathological subtype (OR=14.63, p <0.001) and intermediate-risk subtype (OR=3.37, p <0.001), vertical growth pattern (OR=1.97, p =0.020), higher stage (AJCC: OR=3.66, p <0.001; UICC: OR=2.43, p <0.001), higher tumor grade (OR=3.37, p <0.001), tumor size (>3 cm) (OR=2.00, p =0.002), LVI (OR=3.37, p <0.001), invasion depth (>5 mm) (OR=2.58, p =0.002), nerve invasion (OR=2.84, p <0.001), corpora cavernosum invasion (OR=2.22, p <0.001), corpus spongiosum invasion (OR=1.73, p =0.002) and urethra invasion (OR=1.81, p =0.030). Conclusion Current meta-analysis conclusively identified valuable predictors of inguinal LNM for patients with penile cancer. However, high-quality studies are warranted to further validate our conclusions. The intrinsic link between these predictors needs to be further investigated to create an accurate mathematical prediction model for LNM.

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Section: Introductionmentioning

confidence: 99%

Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies

Hu¹,

Liu²,

Ren³

et al. 2019

CMAR

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“…[37] In addition, we also demonstrated that video endoscopic inguinal lymphadenectomy via a hypogastric subcutaneous approach was safe and effective, and it could avoid the operation on both the limb and abdomen if simultaneous laparoscopic pelvic lymphadenectomy was required. [38]…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical feasibility and oncological outcomes between video endoscopic and open inguinal lymphadenectomy for penile cancer

Hu¹,

Li²,

Liu³

et al. 2019

Medicine

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“…23 Outra forma de diminuir a morbilidade é a realização da LIMVA bilateral em simultâneo por duas equipas cirúrgicas distintas, variante técnica descrita por Pompeo et al em 2013. 10 Apesar do potencial mostrado pela LIMVA, outras técnicas minimamente invasivas têm surgido, nomeadamente a LIMVA robótica 24 e a abordagem por via abdominal/hipogástrica, 25 com resultados comparáveis à LIMVA.…”

Section: Discussionunclassified

Prevenir Complicações: Linfadenectomia Inguinal Modificada Vídeo-Assistida no Estadiamento do Tumor do Pénis

Pereira-Lourenço¹,

Vieira-Brito²,

Godinho³

et al. 2019

aup

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A linfadenectomia inguinal modificada permite um estadiamento correto na maioria dos casos de carcinoma do pénis sem gânglios inguinais palpáveis. Atualmente, é possível reproduzir a técnica cirúrgica clássica por via vídeo-assistida, com resultados oncológicos semelhantes e menor taxa de complicações. O artigo reporta um caso de tumor do pénis, sujeito a penectomia total (pT3NxMx), sem gânglios inguinais palpáveis, onde se realizou uma linfadenectomia inguinal modificada vídeo-assistida (LIMVA) bilateral, sendo descrita a técnica cirúrgica da LIMVA direita. Neste artigo são descritos todos os passos da técnica cirúrgica (posicionamento do doente, disseção romba profundamente à faixa de Scarpa, identificação dos limites anatómicos da disseção, identificação dos vasos femorais, identificação da veia safena até a fossa ovalis, excisão dos gânglios e encerramento). A grande vantagem da LIMVA é a diminuição de complicações pós-operatórias, nomeadamente a baixa taxa de deiscência da ferida operatória e de edema dos membros inferiores.

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Comparative Study of Video Endoscopic Inguinal Lymphadenectomy Through a Hypogastric vs Leg Subcutaneous Approach for Penile Cancer

Abstract: Hypogastric approach is as effective and safe as VEIL-L for penile cancer. Moreover, VEIL-H can avoid the operation on both the limb and abdomen if laparoscopic pelvic lymphadenectomy is required.

Cited by 25 publications

References 22 publications

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

<p>Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies</p>

Comparison of clinical feasibility and oncological outcomes between video endoscopic and open inguinal lymphadenectomy for penile cancer

Prevenir Complicações: Linfadenectomia Inguinal Modificada Vídeo-Assistida no Estadiamento do Tumor do Pénis

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