Comparative study of total protein, and total and lipid‐associated serum sialic acid levels in patients with type 2 diabetes mellitus

Ekin, Suat; Meral, İsmail; Gündüz, Handan; Mert, Nihat

doi:10.1002/jcla.10078

Cited by 15 publications

(12 citation statements)

References 8 publications

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“…10 Serum total sialic acid was significantly increased in the diabetic group compared to the control group (p<0.001). This is similar to the earlier studies by Balu Mahendran et al, 2013;Ekin et al, 2003;Melidonis et al, 1988;Crook et al, 1993. 11 -13 Elevated level of serum sialic acid is a risk factor for overall mortality in type 2 diabetes mellitus patients.…”

Section: Discussionsupporting

confidence: 93%

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Nair¹,

Osman²

2017

jemds

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BACKGROUNDSialic acid, an acetylated derivative of neuraminic acid, is reported to be a marker of acute phase response. Elevated serum total sialic acid concentration may reflect the existence or activity of an atherosclerotic process.The aims and objectives of the current study is to evaluate serum total sialic acid and various lipid parameters in patients with type 2 diabetes mellitus and to examine the relationship between serum total sialic acid with serum lipids which strongly influence the occurrence and advance of atherosclerosis. MATERIALS AND METHODSThe study group consisted of 40 type 2 diabetic patients and 40 healthy controls between the age group of 20 and 60 years. The serum total sialic acids were analysed by the thiobarbituric acid assay of Warren. Fasting plasma glucose and fasting lipid profile were measured by commercially procured kits in a fully autoanalyser. Statistical analysis was done using SPSS version 22.0. Quantitative data was expressed as mean and SD and quantitative data for the two groups were compared with unpaired 't' test. Association between total sialic acid and lipid parameters was assessed by Pearson correlation. p<0.05 is considered significant.

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Section: Discussionsupporting

confidence: 93%

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Nair¹,

Osman²

2017

jemds

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“…Studies had shown that elevated level of SA was significantly associated with pancreatic cancer, colorectal cancer, osteosarcoma, oral squamous cell carcinoma, and other malignancies 18-21. However, it was worth noting that some studies had observed that SA levels was obviously higher in patients with severe infection or Type Ⅱ diabetes compared to healthy people 22, 23. Therefore, when data was enrolled into the present study, any other malignancy, infection, inflammation, diabetes and other correlative factors were eliminated to avoid interference with the finally outcomes.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Sialic Acid Levels Predict Prostate Cancer As Well As Bone Metastases

et al. 2019

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Objective: To evaluate the value of serum sialic acid (SA) in diagnosis of benign prostatic hyperplasia (BPH), prostate cancer (PCa), and bone metastases in PCa patients.Materials and Methods: Data from 540 patients who were newly diagnosed with PCa or BPH between November 2014 and March 2018 were retrospectively collected and analyzed. Pretreatment SA levels were compared across various groups, then, associations between SA levels and clinic parameters of patients were analyzed as well. Univariate and multivariate logistic regression analyses were further used to identify independent associations.Results: The mean SA levels in patients with PCa were significantly higher than with BPH (p = 0.013). Furthermore, PCa patients with bone metastases showed elevated SA levels compared with PCa without bone metastases (p < 0.001). A multivariate logistic regression model showed that: SA level > 52.35 mg/dL was identified to be independently associated with the diagnosis of PCa (HR = 1.645, p = 0.036), and SA level > 59 mg/dL was identified to be independent association with the presence of bone metastases in PCa patients (HR = 6.421, p = 0.012).Conclusions: Elevated SA level is an independent predictor of prostate cancer as well as its bone metastases. Therefore, SA level may be a promising diagnostic and prognostic biomarker for prostate cancer and bone metastases.

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“…It also contrasted Ekin et al, [16] which showed no significant effect of diabetes mellitus on serum total protein. However, reports regarding salivary total protein levels in diabetics are controversial, as they have shown higher levels [11,[17][18][19][20], lower levels [20], or comparable levels between diabetics and healthy non-diabetics [21][22][23][24][25].…”

Section: Serum and Salivary Protein Profile In Diabetes Mellitusmentioning

confidence: 55%

Is Saliva an Alternative Non-Invasive Sample for the Estimation of Protein Profile amongst Diabetics and Gender-based Diagnostics?

Agoro¹,

Ne²,

Sa³

et al. 2017

Anat Physiol

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Comparative study of total protein, and total and lipid‐associated serum sialic acid levels in patients with type 2 diabetes mellitus

Cited by 15 publications

References 8 publications

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

A Study of Serum Sialic Acid Levels in Patients With Type 2 Diabetes Mellitus and Its Relation to Lipid Parameters

Elevated Serum Sialic Acid Levels Predict Prostate Cancer As Well As Bone Metastases

Is Saliva an Alternative Non-Invasive Sample for the Estimation of Protein Profile amongst Diabetics and Gender-based Diagnostics?

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