Comparative study of the ThinPrep Pap test and conventional cytology results in a Canadian cohort

Duggan, Máire A.; Khalil, M.; Brasher, Penny; Nation, Jill

doi:10.1111/j.1365-2303.2006.00340.x

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…Our prevalence rates were very similar to those reported in the study of Turkish Cervical Cancer and Cervical Cytology Group (Turkish Cervical Cancer And Cervical Cytology Research Group 2009), an extended investigation in Turkey. But, the rates of the present study were much lower than the ones reported for Western populations, in general (de Sanjose et al, 2003;Duggan et al, 2006;Kroupis et al, 2007;Kulig et al, 2010;Marques et al, 2011). However, our results were very similar to those reported from other Islamic countries like Saudi Arabia, Egypt, and Iran (Jamal et al, 2003;elAll et al, 2007;Nokiani et al, 2008) that may be ascribed to low prevalence of HPV (Tuncer et al, 2006;Ozalp et al, 2012), religion, or the conservative cultures, akin to Turkish population.…”

Section: Discussioncontrasting

confidence: 80%

“…Hitherto, different studies have exhibited the major and substantial variations considering the rates of ASCUS, LSIL, HSIL, AGUS, and cervical cancer (Forman 2003;Sanjose et al, 2003;Altaf 2006;Duggan et al, 2006;Turkish Cervical Cancer And Cervical Cytology Research Group, 2009;Castle et al, 2010;Kulig et al, 2010). In the present study, 1.83% of the Pap smears had the abnormal cytology, with ASCUS in 1.18%, LSIL in 0.39, HSIL in 0.16%, AGUS in 0.07%, squamous cell carcinoma in 0.02%, and adenoarcinoma in 0.006%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

Şengül¹,

Altınay²,

Oksuz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

Şengül¹,

Altınay²,

Oksuz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In contrast with the often conflicting results from other studies, [7][8][9][10][11]18,23 we found with a high level of evidence that LBC leads to significantly higher proportions of SBLB ec2 results. The reason for this observation is unclear.…”

Section: Resultscontrasting

confidence: 56%

“…This was considered of relevance in view of previous studies that reported increased numbers of tests without endocervical cells while using LBC. [7][8][9][10][11] In addition, the clinical relevance of unsatisfactory results was assessed with follow-up cytology and histology. …”

mentioning

confidence: 99%

Causes and Relevance of Unsatisfactory and Satisfactory but Limited Smears of Liquid-Based Compared With Conventional Cervical Cytology

Siebers¹,

Klinkhamer²,

Vedder³

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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N Context.-Recent randomized controlled trials have shown a significant decrease in unsatisfactory rates for liquid-based cytology (LBC) compared with conventional Papanicolaou test (CP). The underlying causes and relevance of unsatisfactory results for LBC and CP have never been compared within the setting of a randomized controlled trial.Objective.-To examine differences in causes and relevance of unsatisfactory and satisfactory but limited by (SBLB) results for LBC and CP.Design.-Data from the Netherlands ThinPrep Versus Conventional Cytology (NETHCON) trial were used, involving 89 784 women. Causes and relevance of unsatisfactory and SBLB results were analyzed.Results.-The primary cause for unsatisfactory results for CP and LBC was scant cellularity. Other causes for unsatisfactory CPs were virtually eliminated with LBC. The same was true for SBLB subcategories, with the exception of SBLB absence of transformation zone component and SBLB scant cellularity. The SBLB absence of transformation zone component showed a statistically significant 22% and SBLB scant cellularity a 12% nonsignificant increase with LBC. The detection rates of abnormalities found during 18 months of follow-up of unsatisfactory test results did not differ significantly between the 2 study arms, nor did they differ from the initial test positivity rates from the NETHCON trial.Conclusions.-Liquid-based cytology shows an almost complete elimination of most causes for unsatisfactory CP, with scant cellularity remaining as the sole cause for unsatisfactory LBC. On the other hand, with LBC a significant increase of smears without a transformation zone component was noted. Women with an unsatisfactory test result are not at increased risk for cervical abnormalities either with LBC or with CP.Trial Registration.-Nederlands Trial Register, NTR1032, www.trialregister.nl.(Arch Pathol Lab Med. 2012;136:76-83; doi: 10.5858/ arpa.2011-0113-OA) L iquid-based cytology (LBC) has been largely adopted as an alternative to cervical cancer screening with conventional Papanicolaou tests (CP) in many Western countries. However, recent evidence from 2 randomized controlled trials (RCTs) 1,2 and a meta-analysis comparing the performance of LBC and CP 3 supports the conclusion of equal accuracy for both methods. Yet the RCT has shown a significant decrease in unsatisfactory rates for LBC as compared with CP. 4 Unsatisfactory tests account for a number of screening failures, and are a source of distress to women and a waste of resources.5 It is assumed that LBC decreases the unsatisfactory rate by reducing the number of cases that are inadequate because of obscuring inflammatory cells and blood or because of inhomogeneous distribution or bad fixation of cells. However, to our knowledge differences in the underlying causes and relevance of unsatisfactory smear results for LBC as compared with CP have never been investigated within the setting of an RCT. The aim of the study is to examine the underlying causes for inadequacy in LBC and CP, using the data of the Neth...

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“…2 However, there is a scientific debate if the application of LBP over the conventional Pap smear (CP) has improved the clinical effectiveness in cervicovaginal specimen collection and handling, and if LBP is cost beneficial. [3][4][5][6][7] To our knowledge, studies that have compared the overall performance advantage of LBP over CP have assessed only the rate of specimens considered as "Unsatisfactory for Evaluation." 7,8 We conducted a retrospective comparative caseseries study with the primary objective of evaluating the overall performance of LBP with CP, where the overall performance was defined as the sum of the adjusted proportions of unsatisfactory and rejected specimens.…”

mentioning

confidence: 99%

Rejected and Unsatisfactory Specimens: A Comparative Study of Liquid-Based (SurePath) Preparations and Conventional Pap Smears for Cervicovaginal Screening

Stark

2007

Laboratory Medicine

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Volume 38 Number 12 LABMEDICINE 729The ThinPrep 2000 System (Cytyc, Marlborough, MA) and the SurePath Pap Test (BD Diagnostics, Burlington, NC), approved by the Food and Drug Administration (FDA), are based on the liquid-based preparation (LBP) for screening of cervicovaginal smears. 1 The LBP has become the primary method for screening because of the improved specimen quality and detection of squamous intraepithelial lesions. The superiority of the cell preparation technology of LBP has been attributed to the increase in specimen adequacy and the reduced proportion of specimens considered "Unsatisfactory for Evaluation." 2 However, there is a scientific debate if the application of LBP over the conventional Pap smear (CP) has improved the clinical effectiveness in cervicovaginal specimen collection and handling, and if LBP is cost beneficial. [3][4][5][6][7] To our knowledge, studies that have compared the overall performance advantage of LBP over CP have assessed only the rate of specimens considered as "Unsatisfactory for Evaluation." 7,8 We conducted a retrospective comparative caseseries study with the primary objective of evaluating the overall performance of LBP with CP, where the overall performance was defined as the sum of the adjusted proportions of unsatisfactory and rejected specimens. Adjustment for proportions was necessary because the total number of Pap screenings performed during the first phase of the study, when CP was in use, was different from the total number of Pap screenings performed after the implementation of LBP. In addition, we assessed the cited reasons by the laboratory within each category of "Rejected for Evaluation" and "Unsatisfactory for Evaluation." Finally, we compared the difference in the direct cost associated with the rejected and unsatisfactory specimens between LBP and CP. Materials and Methods SettingThe Henry Ford Health System (HFHS) is a comprehensive, self-contained system, organized so that persons in the system receive every level of care from preventive and primary to subspecialty services. The majority of patients at HFHS are insured through the Health Alliance Plan, a non-profit, mixed-model HMO in southeastern Michigan.When a patient is first seen at any of HFHS facilities for any reason, he or she is assigned a permanent and unique lifetime medical record number and is entered into the master patient index database that resides within a larger relational database (the corporate data store). This data store serves as the central repository for patient encounters, billing, and demographic data. Annually, more than 60,000 women undergo cervicovaginal screening at HFHS. In June 2004, the liquid-based technology (SurePath Pap Test) was fully implemented across all outpatient clinics at HFHS.Specimen collections are standardized across the system, and all specimens collected are processed and evaluated in a centralized cytopathology laboratory, affiliated with the same medical group. For specimens that are considered "Unsatisfactory for Evaluation," the laborato...

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Comparative study of the ThinPrep Pap test and conventional cytology results in a Canadian cohort

Abstract: In this population, ThinPrep was superior to the conventional Pap test.

Cited by 16 publications

References 23 publications

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

Causes and Relevance of Unsatisfactory and Satisfactory but Limited Smears of Liquid-Based Compared With Conventional Cervical Cytology

Rejected and Unsatisfactory Specimens: A Comparative Study of Liquid-Based (SurePath) Preparations and Conventional Pap Smears for Cervicovaginal Screening

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