Comparative Study of the Status of a Biomarker of Lipid Peroxidation (Malondialdehyde) in Patients with Plasmodium falciparum and Plasmodium vivax Malaria Infection

Idonije, O. B.; Festus, O.; Okhiai, O; Akpamu, U

doi:10.3923/ajbs.2011.506.513

Cited by 14 publications

(10 citation statements)

References 14 publications

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“…This leads to red cell lysis, anaemia and iron concentration fall. This finding agree with a previous study by Idonije et al [23] who reported a significantly higher concentrations of lipid peroxidation (MDA) in malaria infected patients.…”

Section: Discussionsupporting

confidence: 94%

The Effects of Plasmodium Falciparum Parasitaemia on Liver Synthetic Fidelity and Oxidative Stress Markers

Wankasi

Waibode

Agoro

2020

EJMED

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Malaria has for century’s defiled eradication due to pathophysiological and environmental complexities. The study was aimed at revealing the effect of malaria parasitaemia on hepatic synthetic fidelity and oxidative stress markers individually and synergistically. A total of five hundred subjects constituted the sample size, out of which two hundred comprised the control and three hundred the test group with grades of parasitaemia. Serum aspartate aminotransferases (AST), alanine aminotransferase (ALT), iron, malonaldehyde and glutathione were analysed using WHO approved methods. The results obtained indicated a significant increase (p<0.05) in AST, ALT, malonaldehyde, and glutathione levels in malaria infected subjects when compared to the control group respectively. The result further showed a significant decrease (p<0.01) in serum iron concentration in malaria infected groups when compared to the control. In conclusion, malaria infection has a significant impact on the hepatic synthetic capacity and oxidative indicators. It is suggested that these observed biochemical change should be considered when malaria infected individuals are treated and managed.

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Section: Discussionsupporting

confidence: 94%

The Effects of Plasmodium Falciparum Parasitaemia on Liver Synthetic Fidelity and Oxidative Stress Markers

Wankasi

Waibode

Agoro

2020

EJMED

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“…The patients were in the following categories-adults (n = 11) of 21 to 31 years old and adolescent (n = 10) of 11 to 20 years old. Exclusion criteria for both patients and control subjects included; gastrointestinal tract infection, protein energy malnutrition, renal diseases, cirrhosis, hepatitis, obstructive jaundice, cancer, diabetes mellitus, hypertension, obesity, smoking, alcoholism, persons living with human immunodeficiency virus (HIV), patients taking anti-malaria drugs and vitamin supplements, patients who had treated malaria in the past 2 months (Onyesom and Onyemakonor, 2011;Idonije et al, 2011) and patients with low or high parasitaemia.…”

Section: Study Areamentioning

confidence: 99%

“…They include Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae (Krotoski et al, 1982;Joseph et al, 2011) and more recently, P. knowlesi (Figtree et al, 2010;Lee et al, 2011;Marchand et al, 2011). P. falciparum and P. vivax cause the most serious forms of the disease (World Health Organization (WHO), 2005; Idonije et al, 2011;Joseph et al, 2011). Sporozoites from bite of female mosquitoes (genius Anopheles) infect humans and are the progenitor of the disease condition.…”

Section: Introductionmentioning

confidence: 99%

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

Chidoka¹

2013

J. Med. Lab. Diagn.

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In spite of threats malaria pose to public health, specific records on alterations in some haematologic and biochemical indices of inhabitants of Owerri Municipality infected with P. falciparum malaria have not received wide reports and documentation. Accordingly, the present study sought to investigate alterations in haematologic and biochemical indices of moderately P. falciparum infected male inhabitants of Owerri Municipality. Haematologic and biochemical indices were estimated by spectrophotometric methods. Haemoglobin concentrations of malarious subjects within age brackets of 11 to 20 and 21 to 31 years were below reference interval; [Hb] M;11-21 years = 10.53 ± 0.23 g/dl (p < 0.05); [Hb] M; 21-31 years = 11.51 ± 1.10 g/dl (p < 0.05). There was no significant difference (p > 0.05) in erythrocyte sedimentation rate (ESR) between the two malarious groups; ESR M; 11-20 years = 29.80 ± 0.74 mm/h; ESR M; 21-31 years = 26.51 ± 1.42 mm/h. Packed cell volume (PCV) of malarious subject gave the following values: PCV% M; 11-20 years = 26.82 ± 0.78; PCV% M; 21-31 years = 25.82 ± 0.78; p > 0.05. Serum white blood cell count (WBC) was raised in malarious subjects compared to control groups (p > 0.05) except with WBC × 10 3 M; 21-30 years = 13.77 ± 3.95; p > 0.05. Serum albumin was lower in malarious subjects; [Albumin] M; 11-20 years = 4.70 ± 0.05 mg/dl and [Albumin] M; 21-31 years = 4.31 ± 0.09 mg/dl; p > 0.05, whereas, serum creatinine concentrations of malarious subjects gave higher values: [Creatinine] M; 11-20 years = 0.88 ± 0.71 mg/dl and [Creatinine] M; 21-31 years = 1.14 ± 0.42 mg/dl; p > 0.05. Serum urea concentrations of malarious subjects were significantly (p < 0.05) higher than the corresponding non-malarious age group. Serum fasting blood sugar (FBS) was significantly (p < 0.05) lower in malarious groups compared to corresponding non-malarious subjects. Specifically, [FBS] M; 11-20 years = 63.34 ± 1.66 mg/dl and [FBS] M; 21-31 years = 69.45 ± 1.25 mg/dl; p < 0.05. Subjects with moderate malaria infection showed symptoms of anaemia, alterations in nitrogen and carbohydrate metabolism, exemplified by raised serum level of urea and low level of FBS.

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“…The increase in lipid peroxidation level in malaria patients and decrease in ascorbic acid and reduced glutathione (GSH) was observed to be accountable for the development of oxidative stress in malaria patients (Loria et al, 1999). Thus, malaria infection was found to be associated with lipid peroxidation accompanying reduction in antioxidant capacity (Idonije et al, 2011). Also, the role of the liver in the transmission process of malaria infection makes the mitochondrium a vital organelle that is likely to be critically involved in the biochemical events leading to disease onset (Chicco & Sparagna, 2007).…”

Section: Introductionmentioning

confidence: 99%

Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials

Adisa

Sulaimon

2017

Acta Biochim Pol

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The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection. Six groups of five mice each categorized as healthy control (non-parasitized non-treated group), parasitized-non-treated (PnT), parasitized-chloroquine-treated (positive control), parasitized-Artecxin, -Lonart and -P-Alaxin-treated groups were used for the study. Hepatic antioxidant status was assessed with levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as activity of superoxide dismutase (SOD) and catalase (CAT) in the post mitochondrial and mitochondrial fractions. Mitochondrial membrane integrity was also evaluated with activity of succinate dehydrogenase and levels of phospholipids, cholesterol and proteins in the liver mitochondria. Results revealed that treatment of parasitized mice with the antimalarial drugs significantly (p<0.05) decreased hepatic malondialdehyde (MDA) and mitochondrial membrane phospholipids compared to parasitized untreated group. On the other hand, significantly (p<0.05) elevated succinate dehydrogenase (SDH) activity, mitochondrial membrane cholesterol level, GSH concentration, catalase (CAT) and superoxide dismutase (SOD) activity in the post mitochondrial fraction were obtained. Thus, antimalarial drugs distort mitochondrial membrane integrity and electron transfer but reduce the malaria-induced oxidative stress on the host.

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Comparative Study of the Status of a Biomarker of Lipid Peroxidation (Malondialdehyde) in Patients with Plasmodium falciparum and Plasmodium vivax Malaria Infection

Cited by 14 publications

References 14 publications

The Effects of Plasmodium Falciparum Parasitaemia on Liver Synthetic Fidelity and Oxidative Stress Markers

The Effects of Plasmodium Falciparum Parasitaemia on Liver Synthetic Fidelity and Oxidative Stress Markers

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials

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