Comparative Study of the Immunological Marker IL-6 and the Non-Immunological Marker PCT in Surgery Patients with Infections and Multiple Trauma

Zelzer, Sieglinde; Aigner, Reingard; Khoschsorur, G.; Hofer, H. P.; Schaur, R. J.; Földes-Papp, Zeno

doi:10.2174/1874375700903010124

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…In addition to pro-inflammatory responses, which are one side of the coin in inducing poor outcomes in inflammatory diseases, anti-inflammatory responses followed by these proinflammatory responses may also be present. In non-severe inflammatory conditions, there is good balance between these two sides, and inducing low levels of inflammation may promote the repairing process and manage tissue injuries (154). Overactivation of the immune system in severe inflammatory situations can cause an imbalanced immune response and may lead to early complications and MOF in patients.…”

Section: Il-10mentioning

confidence: 99%

Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities

et al. 2022

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Although cellular and molecular mediators of the immune system have the potential to be prognostic indicators of disease outcomes, temporal interference between diseases might affect the immune mediators, and make them difficult to predict disease complications. Today one of the most important challenges is predicting the prognosis of COVID-19 in the context of other inflammatory diseases such as traumatic injuries. Many diseases with inflammatory properties are usually polyphasic and the kinetics of inflammatory mediators in various inflammatory diseases might be different. To find the most appropriate evaluation time of immune mediators to accurately predict COVID-19 prognosis in the trauma environment, researchers must investigate and compare cellular and molecular alterations based on their kinetics after the start of COVID-19 symptoms and traumatic injuries. The current review aimed to investigate the similarities and differences of common inflammatory mediators (C-reactive protein, procalcitonin, ferritin, and serum amyloid A), cytokine/chemokine levels (IFNs, IL-1, IL-6, TNF-α, IL-10, and IL-4), and immune cell subtypes (neutrophil, monocyte, Th1, Th2, Th17, Treg and CTL) based on the kinetics between patients with COVID-19 and trauma. The mediators may help us to accurately predict the severity of COVID-19 complications and follow up subsequent clinical interventions. These findings could potentially help in a better understanding of COVID-19 and trauma pathogenesis.

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Section: Il-10mentioning

confidence: 99%

Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities

et al. 2022

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Intraoperative clonidine vs lidocaine on hemodynamic response to laryngoscopic intubation and immune function in gynecological surgeries

Mohamed

Hamdy

Awad

2020

Ain-Shams J Anesthesiol

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Background This prospective randomised double-blind study was carried out on forty patients American Society of Anesthesiologists (ASA) physical status I–II , aged 40–60 years, scheduled for elective abdominal gynecological surgeries under general anesthesia after obtaining the approval of the local institutional ethical committee and oral consent of the patients. This study was conducted to evaluate the effects of perioperative intravenous clonidine versus lidocaine on hemodynamic stress response to laryngoscopic intubation, immune function, pain intensity, time to the first request for analgesia, and total dose of analgesic requirement in the first 24 h postoperatively in gynecological surgeries. Results Throughout the study, heart rate and mean arterial blood pressure were significantly lower in clonidine group (group C) compared to lidocaine group (group L). Postoperatively, the levels of IL-6 were significantly higher in (group L) compared to (group C). VAS pain scores were lower in the clonidine group in comparison to the lidocaine group. There was a higher total dose of analgesia in the lidocaine group when compared to the clonidine group. Conclusions Both clonidine and lidocaine can be used to attenuate the hemodynamic response; however, clonidine was better in the reduction of postoperative pain scores and the decrease in the production of pro-inflammatory cytokines.

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Comparative Study of the Immunological Marker IL-6 and the Non-Immunological Marker PCT in Surgery Patients with Infections and Multiple Trauma

Cited by 2 publications

References 33 publications

Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities

Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and Disparities

Intraoperative clonidine vs lidocaine on hemodynamic response to laryngoscopic intubation and immune function in gynecological surgeries

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