Comparative Study of the Epidemiology of Rotavirus in Children from a Community-Based Birth Cohort and a Hospital in South India

Banerjee, Indrani; Ramani, Sasirekha; Primrose, Beryl; Moses, Prabhakar D.; Iturriza‐Gómara, Miren; Gray, James J.; Jaffar, Shabbar; Monica, Bindhu; Muliyil, Jaya Prakash; Brown, David; Estes, Mary K.; Kang, Gagandeep

doi:10.1128/jcm.01882-05

Cited by 106 publications

(85 citation statements)

References 44 publications

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“…The Indian Rotavirus Strain Surveillance Network carried out a multi-centric study in seven different regions of India and reported that rotavirus was detected in stools of 39% children aged <5 years [3]. Inclusion of children at hospitals caring for lower acuity diarrheal episodes or less severe disease may account for a lower percentage of rotavirus positive cases among the total number of enrolled patients in our study compared with previous studies [3,[8][9][10][11][12][13][14][15].…”

Section: Fig 2 Monthly Distribution Of Rotavirus-positive Patients mentioning

confidence: 65%

Prevalence of rotavirus diarrhea among hospitalized under-five children

et al. 2013

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Section: Fig 2 Monthly Distribution Of Rotavirus-positive Patients mentioning

confidence: 65%

Prevalence of rotavirus diarrhea among hospitalized under-five children

et al. 2013

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“…Additionally, the incidence decreased with time in all age groups and the total number of episodes decreased from [2007][2008]. According to Aracaju's Public Health Department (www.datasus.gov.br), acute diarrhoea incidence in the Rotavirus + Rotavirus -study area decreased from 59.8-52.5 episodes per 1,000 children during the two years this study was conducted and the higher incidence observed among the cohorts is likely reflects the increased sensitivity of active household surveillance, which identified mild cases that were managed at home, as previously described (Banerjee et al 2006, Vernacchio et al 2006. In addition to the low incidence of all-cause diarrhoea, very few children had documented rotavirusborne diarrhoea during the two years this study was conducted.…”

Section: Discussionmentioning

confidence: 86%

“…study area decreased from 59.8-52.5 episodes per 1,000 children during the two years this study was conducted and the higher incidence observed among the cohorts is likely reflects the increased sensitivity of active household surveillance, which identified mild cases that were managed at home, as previously described (Banerjee et al 2006, Vernacchio et al 2006.…”

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confidence: 92%

Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil

Vieira

Gurgel

Kirby

et al. 2011

Mem. Inst. Oswaldo Cruz

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Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix ® ) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 2006 from a low-income residential area inNortheast Brazil. The children were monitored every two weeks for two years. Stool samples from children with diarrhoea were examined for the presence of rotavirus. Rotaviruses were genotyped using real time-polymerase chain reaction. The mean numbers of all-cause diarrhoea episodes/child (adjusted for age) in the first year were 0. 87 and 0.84, in vaccinated and unvaccinated children, respectively. During the second year, the number of episodes/ child decreased to 0.52 and 0.42. Only 16 (4.9%) of 330 stool samples were rotavirus-positive (10 vaccinated and 6 unvaccinated children) and only P[4]G2 rotaviruses were identified. All-cause diarrhoea episodes were more severe in unvaccinated children in the first year of age (p < 0.05), while vaccinated children had more severe episodes 18 months after vaccination. Rotavirus diarrhoea incidence was very low in both groups. Key words: diarrhoea -rotavirus -vaccine -cohort -children -BrazilRotavirus diarrhoea in vaccinated children • Sarah Cristina Fontes Vieira et al. 331ties were visited at home in 2006 and their parents were invited to enrol their children in the study, independent of their vaccination status. The parents of the first 250 children who had received two oral doses of the Rotarix ® vaccine (GlaxoSmithKline Biologicals, Rixensart, Belgium) at two and four months of age (vaccinated cohort) were invited to participate and a further 250 children who had not received the vaccine comprised the unvaccinated cohort. Vaccination status was verified using the child's vaccination card and the Health Centre's databases. The youngest unvaccinated children registered were selected, despite the fact that the two groups could not be matched by age, as unvaccinated children had to be ineligible for vaccination at the time of enrolment, and therefore at least four months of age. Unvaccinated children serving as the control group were not offered the vaccine due to EPI guidelines that exclude children greater than or e�ual to four months of age to avoid the risk of intussusception among older infants (WHO 2007).After obtaining informed parental consent, all children were visited at home for the following two years, independently of their age at the time of enrolment. Visits were conducted every two weeks by three trained interviewers who in�uired as to whether or not the child had experienced diarrhoea episodes during the previous twoweek period. If the parent indicated that the child had diarrhoea, the interviewer collected information regarding the date of the episode and clinical presentation. The severity of the diarrhoea episodes wa...

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“…This fact has been corroborated in other hospital based studies where rotavirus diarrhea has been found to be 13% (inter study variation of 10e25%) in children less than 6 months. 6,7 This variation has been attributed to less severe disease in young children due to persistence of maternal antibodies. 12,13 In a multicentric study conducted by Kang et al, rotavirus detection rates were greatest among children aged 6e23 months.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of rotavirus infection in children below two years presenting with diarrhea

John

Devgan

Mitra

2014

Medical Journal Armed Forces India

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DiarrheaPrevalence Children a b s t r a c t Background: Rotavirus is a common cause of diarrhea in children. There is a need for data on prevalence of rotavirus diarrhea especially in our setting. This study was carried out to determine the prevalence of rotavirus infection in children upto two years presenting with diarrhea and to ascertain factors associated with rotavirus infection in them.Methods: A cross sectional observational study was carried out to determine the prevalence of rotavirus infection amongst children less than 2 years presenting with diarrhea. The clinical profile of the children was analyzed along with detection of rotavirus antigen in stool.Results: A total of 250 children with diarrhea were included in the study. The Male: Female ratio was 0.97:1. We found 24% children presenting with diarrhea to be positive for rotavirus antigen. 78.3% of children with rotaviral diarrhea were in the age group of 6e15 months. There was a significant association between type of feeding and rotavirus diarrhea with reduced prevalence while on exclusive breast-feeding. Though only 10.4% of children with rotavirus diarrhea had severe dehydration, 61.5% of children with severe dehydration were positive for rotavirus. Conclusion:Rotavirus diarrhea caused substantial morbidity in our study population. The rotavirus positivity in these children was 24% and there was a significant association of rotavirus infection with type of feeding and severity of dehydration.ª 2014, Armed Forces Medical Services (AFMS). All rights reserved.

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Comparative Study of the Epidemiology of Rotavirus in Children from a Community-Based Birth Cohort and a Hospital in South India

Cited by 106 publications

References 44 publications

Prevalence of rotavirus diarrhea among hospitalized under-five children

Prevalence of rotavirus diarrhea among hospitalized under-five children

Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil

Prevalence of rotavirus infection in children below two years presenting with diarrhea

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