Comparative Study of the Efficacy of Prebiotics and Probiotics as Dietary Supplements in Rats with Gastric Ulcer

Abstract

Gastric ulcer is considered as main problem of gastrointestinal disease, presenting one of the most important health issues in all societies. This comparative study designed to explore the anti-ulcerogenic role of probiotics and prebiotics and to evaluate the most potent effect against gastric ulcer. Sixty rats were distributed into 6 groups : G1 Healthy control; G2 gastric ulcer (GU), ulcer was induced by four oral doses of Aspirin 200 mg/kg b.w./week ;G3 Prebiotics (PreB) administered orally group ( 0.5 g/day); G4 Probiotics (ProB) administered orally group ( 0.5 mg/day); G5 Prebiotics (Therapeutic): prebiotics was administered orally at dose ( 0.5g/day) for 30 days after induction of gastric ulcer (GU+PreB); G6 Probiotics (Therapeutic): probiotics was administered orally at dose ( 0.5mg/day) for 30 days after induction of gastric ulcer (GU+ProB). Oxidative stress parameters and inflammatory markers were measured. Results revealed that: aspirin caused gastric ulcer associated with increased MDA, TNF-α, IL-6, and IL-10 and decreased gastroprotective mediators SOD, GSH, CAT, and PGE2compared with control rats. Treatment with prebiotics or probiotics efficiently reduces gastric injury, oxidative stress and proinflammatory cytokines. Comparing treatment groups showed that, Probiotics as a therapeutic group was the most potent demonstrated a hopeful role against gastric ulcer.

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“…The fermentation product of FOS by beneficial bacteria in the large intestine is SCFAs that indirectly scavenge ROS. [28,32] Further, it could be suggested that FOS supplementation might have increased the beneficial bacterial population that protected the gut epithelium from oxidative stress. As reported earlier, this study's significantly decreasing body and gut weight indicates LPS-induced systemic toxicity.…”

Pathogenesis of Gizzard Erosion and Ulcerations and Comprehensive Control Strategy in Poultry

“…In another study, B. cereus, co-infection with avian influenza virus H9N2 or Chlamydia psittaci induced GEU, respiratory distress and pneumonia in SPF chickens (Zhang et al 2019;Zuo et al 2020). Gastric ulcers are initiated and exacerbated by increased acid secretion and a weakened mucosal barrier (Al-garni et al 2021). Feed microbial contamination will generate the majority of biogenic amines (histamine) which catalyzes the secretion of gastric acid.…”