Comparative Study of the Effects of Medetomidine and Xylazine in Cats

Cardoso, Cléber Salesse; Jorge, Elisa Bacco; Santos, Aline Bozzetto dos; Smerdel, João Paulo Silva; Silva, Luis Roberto Almeida Gabriel; Andrade, Silvia Franco

doi:10.5747/ca.2011.v07.n1.a66

Cited by 2 publications

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“…Despite maintaining normal heart rates throughout the immobilization, some of the lions in each group experienced skipped heart beats, which resulted in arrhythmias. Vagal-induced arrhythmias, including first- and second-degree atrioventricular (AV) blocks, are commonly reported adverse effects of α 2 -agonists ( Vainio and Palmu, 1989 ; Short, 1991 ; Sinclair, 2003 ; Cardoso et al, 2011 ; Saponaro et al, 2013 ). An AV block is a condition in which impulse conduction from the atria to the ventricles is delayed or blocked ( Lev, 1964 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions

Donaldson

Meyer

Fuller

et al. 2023

Conservation Physiology

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Thirty-six free-ranging lions (12 per group) were immobilized with tiletamine–zolazepam (Zoletil 0.6 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (TZM), ketamine (3.0 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (KM) or ketamine (1.2 mg/kg i.m.) plus butorphanol (0.24 mg/kg i.m.) plus medetomidine (0.036 mg/kg i.m.) (KBM). During immobilization cardiovascular variables were monitored at 5-minute intervals for a period of 30 minutes. Lions immobilized with all three drug combinations were severely hypertensive. Systolic arterial pressure was higher at initial sampling in lions immobilized with KM (237.3 ± 24.8 mmHg) than in those immobilized with TZM (221.0 ± 18.1 mmHg) or KBM (226.0 ± 20.6 mmHg) and decreased to 205.8 ± 19.4, 197.7 ± 23.7 and 196.3 ± 17.7 mmHg, respectively. Heart rates were within normal ranges for healthy, awake lions and decreased throughout the immobilization regardless of drug combination used. Lions immobilized with TZM had a higher occurrence (66%) of skipped heart beats than those immobilized with KBM (25%). The three drug combinations all caused negative cardiovascular effects, which were less when KBM was used, but adverse enough to warrant further investigations to determine if these effects can be reversed or prevented when these three combinations are used to immobilize free-living lions.

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Section: Discussionmentioning

confidence: 99%

Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions

Donaldson

Meyer

Fuller

et al. 2023

Conservation Physiology

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“…Pre-anesthetic drugs, such as medetomidine and atipamezole, are used in anesthetic protocols in different domestic and wild species due to their excellent sedative effects. They have been used to preanesthestize raccoons [ 11 ], camels [ 12 ], reindeers [ 13 ], and cats [ 14 ]. However, the implications of their application to the reproductive tract have not been investigated in wild species.…”

Section: Introductionmentioning

confidence: 99%

Effects of atipamezole and medetomidine administration on seminal variables and functions of erection and ejaculation of the collared peccary (Tayassu tajacu) after electroejaculation

et al. 2014

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BackgroundAlpha adrenergic drugs are usually used in the treatment of erectile and ejaculatory dysfunction in humans. The influence of such drugs on the seminal characteristics of wild animals has not been verified; whereas their impact on the seminal characteristics and erectile and ejaculatory functions of collared peccaries (Tayassu tajacu) has already been determined. This study aimed at investigating and comparing the effects of medetomidine and atipamezole on the seminal variables of collared peccaries undergoing electroejaculation as well as at determining whether these drugs affected the erectile and ejaculatory functions of this species.ResultsA statistically significant difference in sperm concentration was observed between AP (100.0 ± 26.0 × 106 sperm/ml) and MP (220.2 ± 49.8 × 106 sperm/ml); however, both these treatments did not differ from P treatment (180.0 ± 50.7 × 106 sperm/ml). No statistically significant difference was observed among all treatments with regard to erectile function. With regard to ejaculation time, no significant difference was observed between the MP and AP treatments; however, when compared with the P treatment, AP exhibited a significantly higher difference.ConclusionsWhen collared peccaries were anesthetized with propofol, neither medetomidine nor atipamezole significantly affected the characteristics of the semen or the erectile function, despite the fact that the AP treatment increased ejaculation time. Therefore, the data indicate that using propofol alone is an effective anesthetic protocol for collecting semen in collared peccaries. Other non-injectable anesthetic drugs, such as inhaled anesthetics, may be used in future research to collect semen from peccaries.

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Comparative Study of the Effects of Medetomidine and Xylazine in Cats

Cited by 2 publications

References 0 publications

Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions

Comparison of the cardiovascular effects of immobilization with three different drug combinations in free-ranging African lions

Effects of atipamezole and medetomidine administration on seminal variables and functions of erection and ejaculation of the collared peccary (Tayassu tajacu) after electroejaculation

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