Comparative study of the effect of Thymus daenensis gel 5% and diclofenac in patients with knee osteoarthritis

Abstract

Background: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient. Thymus daenensis has been used since old times for the treatment of bone and joint deformities and pain in traditional medicine. Purpose: This study was conducted to examine traditional usages and pharmacological features of T. daen- ensis with respect to the effect of the plant in patients with osteoarthritis. Methods: 120 patients with osteoarthritis were divided into 3 groups. Patients in each group were treated by 5% Thymus daenensis gel, 1% diclofenac gel, or placebo for 6 weeks, along with oral celecoxib capsules. Patients were assessed in different intervals, based on the VAS score for assessment of pain in the joint and different dimensions of WOMAC questionnaire. Results: Pain level (P < 0.005), stiffness during the day (P < 0.05), morning stiffness (P < 0.05) and physi- cal performance (P < 0.05) were significantly different among the groups. Conclusions: Thymus daenensis gel improves the symptoms in patients equal and without significant difference than diclofenac group. It can be argued that its use can produce a satisfactory effect on patients with osteoarthritis due to its low cost, easy access, the plant’s natively occurring in Iran.

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“…However, most pharmaceutical studies have mainly focused on the beneficial properties of the plants and their safe and toxic doses and side effects of them have not been sufficiently investigated. So to ensure the safety of herbal drugs, the study of the longterm and short-term toxic effects of these drugs is essential [1,2]. Acute or lethal toxicity refers to a chemical compound's ability to lead to death relatively soon after being orally ingested, or after being exposed, e.g., as a gas in the air, for four hours.…”

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“…The synthesis of chondrolytic enzymes and proinflammatory mediators by the inflamed synovium leads to cartilage destruction, which enhances synovial inflammation, forming a vicious cycle [8,9]. OA synovial cells sustain arthritic pathology by excreting chondrolytic enzymes and inflammatory mediators [8,10,11]. Synoviumtargeted therapy could theoretically slow OA progression and lessen the severity of OA symptoms [12,13].…”