Comparative Study of the Clinical Presentation of Legionella Pneumonia and Other Community-Acquired Pneumonias

Sopena, Nieves; Sabria-Leal, M.; Pedro-Botet, M. L.; Padilla, Eduardo; Domínguez, José; Morera, Josep; Tudela, Pere

doi:10.1378/chest.113.5.1195

Cited by 194 publications

(108 citation statements)

References 31 publications

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“…Some validated commercial MIF kits [17,18] have been used by many clinical laboratories and researchers [11,17,[19][20][21]. Laboratorial diagnosis of C. pneumoniae infection in our study was established on the basis of a significant and clear-cut antibody response by MIF test as reported [11] and recommended [5]; we use seroconversion as criterium of definite acute infection as others [6].…”

Section: Discussionmentioning

confidence: 99%

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Chedid¹,

Chedid²,

Ilha³

et al. 2007

Braz J Infect Dis

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As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR antigens, from which 23 (39.6%) had previous infection; 3 patients (5.2%) were diagnosed with CAP by TWAR and got cured. The incidence of TWAR CAP in our hospital by seroconversion was 5.2%. Our incidence of 5.2% is probably underestimated since TWAR culture was not available; we suggest that Real-Time PCR be used along with other diagnostic methods in future studies to detect the actual incidence of TWAR CAP. We propose that the serological criterion of IgM ≥1:16 alone to the diagnosis of acute infection by TWAR are discontinued due a lack of specificity.

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Section: Discussionmentioning

confidence: 99%

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Chedid¹,

Chedid²,

Ilha³

et al. 2007

Braz J Infect Dis

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“…In Western countries, Legionella pneumophila is, according to most studies, among the three most common causes of community-acquired pneumonia and it is the second-highest cause of severe pneumonia (1).…”

Section: Introductionmentioning

confidence: 99%

Legionella Pneumonia due to Exposure to 24-hour Bath Water Contaminated by Legionella pneumophila Serogroup-5

Mineshita¹,

Nakamori²,

Seida³

et al. 2005

Intern. Med.

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A 79-year-old man was admitted to hospital from his nursing home for treatment of pneumonia, but died 7 days after admission. Legionella pneumonia was diagnosed after isolation of Legionella pneumophila serogroup-5 from sputum culture. The environment of the nursing home was investigated; only water specimens from the 24-hour bath were positive by culture for Legionella pneumophila serogroup-5. Subsequent analysis by pulsed-field gel electrophoresis revealed an identical pattern in isolates from both sputum culture and 24 hour bath water culture. Among 123 inpatients and staff of the nursing home, 17 were found to be seropositive for Legionella pneumophila serogroup-5.

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“…In a previous study (14) univariate analysis showed that CAP by LP was more frequent in middle-aged, healthy male patients than CAP by another etiology. Moreover, the lack of response to previous -lactamic drugs, headache, diarrhea, severe hyponatremia, and elevation in serum CK levels on presentation were more frequent in NLCAP by LCAP, while cough, expectoration, and thoracic pain were more frequent in NLCAP by another bacterial etiology.…”

Section: Discussionmentioning

confidence: 86%

“…Variables studied: For analysis we considered the most predictive variables (table I) according to a previous study (14): (1) demographic variables: age, sex ; (2) risk factors: smoking, chronic alcoholism; underlying disease, including COPD, HIV infection, solid or hematologic neoplasm; pharmacologic immunosuppression (steroids and chemotherapy); (3) variables of clinical presentation: cough, expectoration, thoracic pain, headache, confusion, diarrhea and antibiotic treatment with beta-lactamic drugs prior to pneumonia; (4) analytical data: sodium (Na), creatine kinase (CK) and glutamic oxaloacetic transaminase (GOT).…”

Section: Methodsmentioning

confidence: 99%

Feature Selection, Ranking of Each Feature and Classification for the Diagnosis of Community Acquired Legionella Pneumonia

Monte

Casals

Fiz³

et al. 2001

Bio-Inspired Applications of Connectionism

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Abstract. Diagnosis of community acquired legionella pneumonia (CALP) is currently performed by means of laboratory techniques which may delay diagnosis several hours. To determine whether ANN can categorize CALP and non-legionella community-acquired pneumonia (NLCAP) and be standard for use by clinicians, we prospectively studied 203 patients with community-acquired pneumonia (CAP) diagnosed by laboratory tests. Twenty one clinical and analytical variables were recorded to train a neural net with two classes (LCAP or NLCAP class). In this paper we deal with the problem of diagnosis, feature selection, and ranking of the features as a function of their classification importance, and the design of a classifier the criteria of maximizing the ROC (Receiving operating characteristics) area, which gives a good trade-off between true positives and false negatives. In order to guarantee the validity of the statistics; the train-validation-test databases were rotated by the jackknife technique, and a multistarting procedure was done in order to make the system insensitive to local maxima.

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Comparative Study of the Clinical Presentation of Legionella Pneumonia and Other Community-Acquired Pneumonias

Cited by 194 publications

References 31 publications

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Legionella Pneumonia due to Exposure to 24-hour Bath Water Contaminated by Legionella pneumophila Serogroup-5

Feature Selection, Ranking of Each Feature and Classification for the Diagnosis of Community Acquired Legionella Pneumonia

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