Comparative study of the biological activity of organosilicon and organogermanium compounds

Abstract

The literature data and the results of our own investigations on the comparative study of the biological activity of isostructural organogermanium and organosilicon compounds have been summarized. It has been shown that the series of organogermanium and organosilicon compounds is more active than the carbon analogues, the majority of organogermanium compounds are less toxic than the sila analogues, the biological activity of the compounds under study appears to be similar but can dramatically differ in the degree of activity, and, moreover, in some particular cases sila and germa analogues exhibit the opposite biological effects.

Furan derivatives of group IV elements (review)

“…Moreover, the toxicity of the silylfuryl derivative (LDso > 1003 mg/kg) in experiments on mice is considerably lower than that of nifedipine (185 mg/kg). The replacement of the trimethylsilyl group by trimethylgermyl leads to a threefold reduction of the toxicity [481]. The derivatives of 6-aminopenicillanic acid containing 5-trmmthylgermylfuryl substituents have some bacteriostatic activity on the gram-positive bacteria &aphylococcus aureus (1.5 and 12.5 #g/ml for compounds A and B respectively) and are inactive toward the gram-negative bacteria Es'cherichia coli (> 2{)0/~g/ml).…”

Synthesis, psychotropic and anticancer activity of 2,2‐dimethyl‐5‐[5′‐trialkylgermyl(silyl)‐2′‐hetarylidene]‐1,3‐dioxane‐4,6‐diones and their analogues

“…At the same time, the majority of organogermanium compounds are less toxic than the analogous organosilicon compounds. 20 Thus, the main idea of the proposed investigation was the search for new effective anticancer and psychotropic substances in a series of heterocyclic compounds with an unsaturated substituent containing a carbonyl group and the determination of the influence of organosilicon and organogermanium substituents on the biological activity.…”

Untitled

“…Silatranes, for example, as a class of pentacoordinated silicon compounds are known for more than three decades, and their specific biological, [2][3] physico-chemical [4][5] and str uctural [6][7] properties still attract research interests. Although the investigation results were published in many papers, [8][9][10] most of them deal solely with the intriguing properties study of these compounds.…”

“…The original way of silatrane synthesis from ethoxysilanes and boratrane in the presence of Al(Oi-Pr) 3 or Al 2 Cl 6 has also been described. 12 Recently, Laine and colleagues have found a way to synthesize organosilicon compounds directly from a very inexpensive starting material, silica (SiO 2 ), and ethylene glycol in only one step.…”