Comparative study of systemic psoralen and ultraviolet <scp>A</scp> and narrowband ultraviolet <scp>B</scp> in treatment of chronic urticaria

Khafagy, Naziha Hafez; Salem, Samar Abdallah Mohamed; Ghaly, Enas Guirguis

doi:10.1111/phpp.12008

Cited by 22 publications

(15 citation statements)

References 25 publications

(31 reference statements)

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“…A study by Khefagy et al . confirmed that NB‐UVB and PUVA showed comparable efficacy in the treatment of CU with minimal side effects. Finally, a recent randomized prospective observer blinded study confirmed the efficacy of PUVA and NB‐UVB in steroid‐dependent CSU.…”

Section: Inducible Urticariassupporting

confidence: 58%

How to manage chronic urticaria ‘beyond’ guidelines: a practical algorithm

Rutkowski

Grattan

2017

Clin Experimental Allergy

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Chronic urticaria (CU) is a disease characterized by pruritic weals, angio-oedema or both occurring for at least 6 weeks. It encompasses spontaneous and inducible urticarias. The national and international guidelines outline the principles of treatment. Omalizumab, an anti-immunoglobulin E monoclonal antibody, has transformed the management of many severe and treatment-refractory patients. However, current UK guidance on its use does not address the needs of those with less severe disease, inducible urticarias, idiopathic histaminergic angio-oedema without weals as a presentation of CU and omalizumab non-responders. Our algorithm and a summary of the evidence to support its principles offers guidance and a more systematic targeted approach to using a range of 'off-label' agents for specific phenotypes of CU. It will be of use when guideline-recommended mast cell mediator antagonists fail to control symptoms and/or using omalizumab is ineffective, not practical or unfunded.

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Section: Inducible Urticariassupporting

confidence: 58%

How to manage chronic urticaria ‘beyond’ guidelines: a practical algorithm

Rutkowski

Grattan

2017

Clin Experimental Allergy

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“…first reported improvement in CU following PUVA therapy in a patient who had co‐existing vitiligo and CU. A few subsequent studies reported a beneficial effect of different phototherapeutic modalities in the treatment of CU . Most of these studies are limited by small sample size and lack of definition of the baseline refractoriness of the disease.…”

Section: Discussionmentioning

confidence: 81%

“…Phototherapy has been found to be effective in the treatment of mastocytosis, dermographism and CU . The exact mechanism of action of phototherapy in urticaria is unknown.…”

mentioning

confidence: 99%

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Phototherapy using narrowband ultraviolet B and psoralen plus ultraviolet A is beneficial in steroid‐dependent antihistamine‐refractory chronic urticaria: a randomized, prospective observer‐blinded comparative study

2016

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“…However, the shortcomings of this study are the lack of a prespecified power calculation and inclusion of a control group, which would have enabled a more rigorous evaluation of the placebo‐deducted effect of phototherapy in CSU. To this end, the study provides no new knowledge compared with a previous smaller RCT, which also compared NB‐UVB with PUVA for CSU and to an RCT that evaluated NB‐UVB additionally to antihistamines in CSU . Also, a longer follow‐up time and an active comparison with one of the recommended drugs for CSU, such as omalizumab, would have been desirable.…”

mentioning

confidence: 98%