Comparative study of some treatment modalities of rosacea

Mostafa, Fawzia Farag; Harras, Mona; Gomaa, Shady; Mokadem, Sahar Al; Nassar, Amany; Gawad, E H Abdel

doi:10.1111/j.1468-3083.2008.02940.x

Cited by 17 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the other comparisons consisted of single studies and investigated drug, e.g. permethrin, benzoyl peroxide, benzoyl peroxide combined with clindamycin, sodium sulphacetamide 10%/sulphur 5%, pimecrolimus, topical erythromycin, topical ciclosporin, ethoxybenzylaldehyde and adjunctive benefit of a polyhydroxy acid (PHA) regimen and flavonoid‐rich cream 15,16,28,39–49 . The results are reported in Table 3, but are not discussed as most of these studies were judged to be at high risk of bias and had skewed or unusable data.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review

Zuuren

Kramer

Carter

et al. 2011

British Journal of Dermatology

View full text Add to dashboard Cite

Summary Rosacea is a common chronic skin disease affecting the face. There are numerous treatment options, but it is unclear which are the most effective. The aim of this review was to assess the evidence for the efficacy and safety of treatments for rosacea. Searches included the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE, EMBASE, Science Citation Index, and Ongoing Trials Registers (updated February 2011). Randomized controlled trials in people with moderate to severe rosacea were included. Fifty‐eight trials, including 27 from the original review, comprising 6633 participants were included in this updated review. Interventions included topical metronidazole, oral antibiotics, topical azelaic cream or gel, topical benzoyl peroxide and/or combined with topical antibiotics, sulphacetamide/sulphur, and others. There was some evidence that topical metronidazole and azelaic acid were more effective than placebo. Two trials indicated that doxycycline 40 mg was more effective than placebo. There was no statistically significant difference in effectiveness between doxycycline 40 mg and 100 mg but there were fewer adverse effects. One study reported that ciclosporin ophthalmic emulsion was significantly more effective than artificial tears for treating ocular rosacea. Although the majority of included studies were assessed as being at high or unclear risk of bias, there was some evidence to support the effectiveness of topical metronidazole, azelaic acid and doxycycline (40 mg) in the treatment of moderate to severe rosacea, and ciclosporin 0·05% ophthalmic emulsion for ocular rosacea. Further well‐designed, adequately powered randomized controlled trials are required.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The evidence for the effectiveness of permethrin was inconclusive and therefore further trials with a rigorous study design are required 28,45 …”

Section: Discussionmentioning

confidence: 99%

Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review

Zuuren

Kramer

Carter

et al. 2011

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…All medications and cosmetics were discontinued from at least 2 weeks prior to participation to the end of the treatment course . Identical oil‐free moisturizing creams, oil‐free sunscreen creams, and gentle soap‐free cleansing bars were prescribed for all patients.…”

Section: Methodsmentioning

confidence: 99%

“…Considering the possible role of Demodex folliculorum in the pathophysiology of rosacea, scabicidal agents such as crotamiton, lindane and permethrin could be effective options against this condition. Only two randomized controlled clinical trials have studied the benefits of permethrin 5% cream on signs and symptoms of rosacea patients; nevertheless, none assessed its effects on Dd . Two other clinical trials have studied the acaricidal effects of permethrin on Dd in various Demodex ‐related dermatological conditions .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of permethrin 5% topical gel vs. placebo for rosacea: a double‐blind randomized controlled clinical trial

Raoufinejad

Mansouri

Rajabi

et al. 2016

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…A multicenter observational uncontrolled study of 2456 patients (aged 2–70 years), reported that use of Mimyx was associated with clinical improvement (including pruritus, erythema, excoriation, dryness, lichenification, scaling, and sleep quality) and reduction of topical steroid usage 61. EpiCeram is triple-lipid barrier repair cream containing ceramides, cholesterol, and free fatty acids.…”

Section: Therapy Of Atopic Dermatitis: Overviewmentioning

confidence: 99%

Update on the management of chronic eczema: new approaches and emerging treatment options

Walling¹

2010

CCID

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common disease with worldwide prevalence, affecting up to 20% of children and 3% of adults. Recent evidence regarding pathogenesis has implicated epidermal barrier defects deriving from filagrin mutations with resulting secondary inflammation. In this report, the authors comprehensively review the literature on atopic dermatitis therapy, including topical and systemic options. Most cases of AD will benefit from emollients to enhance the barrier function of skin. Topical corticosteroids are first-line therapy for most cases of AD. Topical calcineurin inhibitors (tacrolimus ointment, pimecrolimus cream) are considered second line therapy. Several novel barrier-enhancing prescription creams are also available. Moderate to severe cases inadequately controlled with topical therapy may require phototherapy or systemic therapy. The most commonly employed phototherapy modalites are narrow-band UVB, broadband UVB, and UVA1. Traditional systemic therapies include short-term corticosteroids, cyclosporine (considered to be the gold standard), methotrexate, azathioprine, mycophenolate mofetil, and most recently leflunamide. Biologic therapies include recombinant monoclonal antibodies acting on the immunoglobulin E / interleukin-5 pathway (omalizumab, mepolizumab), acting as tumor necrosis factor-α inhibitors (infliximab, etanercept, adalimumab), and acting as T-cell (alefacept) and B-cell (rituxumab) inhibitors, as well as interferon γ and intravenous immunoglobulin. Efficacy, safety, and tolerability are reviewed for each medication.

show abstract

Comparative study of some treatment modalities of rosacea

Abstract: Azelaic acid 20% cream provides an effective and safe alternative to metronidazole 0.75% cream or permethrin 5% cream with the added benefit of increased patient satisfaction.

Cited by 17 publications

References 22 publications

Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review

Effective and evidence‐based management strategies for rosacea: summary of a Cochrane systematic review

Efficacy and safety of permethrin 5% topical gel vs. placebo for rosacea: a double‐blind randomized controlled clinical trial

Update on the management of chronic eczema: new approaches and emerging treatment options

Contact Info

Product

Resources

About