Comparative study of single dose pre-emptive pregabalin vs. Placebo for post-operative pain relief in middle ear surgery

Jadeja, Chetna A; Khatri, Hardik; Oza, Vrinda; Parmar, Vandana

doi:10.7439/ijbar.v5i3.678

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Thirty studies had included data on the sedative effects of pregabalin, 13 , 14 , 21 , 22 , 25 , 29 , 30 , 32 , 37 , 39 , 43 , 50 – 52 , 55 – 57 , 59 , 60 , 62 , 65 – 69 , 77 , 79 , 82 , 85 , 87 , 88 with a total of 1147 patients taking pregabalin and 1170 patients on the control treatment. Subgroup analysis was performed on studies according to the surgical categories (number of studies) under cardiothoracic surgery (2), ENT surgery (3), gynecologic surgery (4), laparoscopic cholecystectomy (2), orthopedic surgery (7), spine surgery (6), and miscellaneous surgery (6).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one studies had included data on nausea prevalence after pregabalin administration, 13 , 21 , 24 , 26 , 28 , 30 , 33 , 37 , 44 , 46 , 47 , 50 – 52 , 54 , 56 , 57 , 59 , 60 , 63 – 65 , 67 , 68 , 70 , 71 , 77 , 85 , 86 , 88 with a total of 1067 patients taking pregabalin and 1038 patients on the control treatment. It was found that there was no difference in nausea incidence in cardiothoracic surgery, ENT surgery, gynecologic surgery, laparoscopic cholecystectomy, and spine surgery between pregabalin and control treatment groups.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 22 studies provided information on vomiting incidence after pregabalin administration, 13 , 21 , 23 , 25 , 44 , 46 , 47 , 50 – 52 , 54 , 56 , 59 , 60 , 63 , 65 , 67 , 68 , 70 , 71 , 77 , 85 with 826 patients treated with pregabalin and 816 on control treatment. The different surgical categories were cardiothoracic surgery (1), ENT surgery (3), laparoscopic cholecystectomy (3), miscellaneous surgery (4), orthopedic surgery (7), and spine surgery (4).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories

et al. 2015

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The efficacy of pregabalin in acute postsurgical pain has been demonstrated in numerous studies; however, the analgesic efficacy and adverse effects of using pregabalin in various surgical procedures remain uncertain. We aim to assess the postsurgical analgesic efficacy and adverse events after pregabalin administration under different surgical categories using a systematic review and meta-analysis of randomized controlled trials.A search of the literature was performed between August 2014 to April 2015, using PubMed, Ovid via EMBASE, Google Scholar, and ClinicalTrials.gov with no limitation on publication year or language. Studies considered for inclusion were randomized controlled trials, reporting on relevant outcomes (2-, 24-hour pain scores, or 24 hour morphine-equivalent consumption) with treatment with perioperative pregabalin.Seventy-four studies were included. Pregabalin reduced pain scores at 2 hours in all categories: cardiothoracic (Hedge's g and 95%CI, −0.442 [−0.752 to −0.132], P = 0.005), ENT (Hedge g and 95%CI, −0.684 [−1.051 to −0.316], P < 0.0001), gynecologic (Hedge g, 95%CI, −0.792 [−1.235 to −0.350], P < 0.0001), laparoscopic cholecystectomy (Hedge g, 95%CI, –0.600 [–0.989 to –0.210], P = 0.003), orthopedic (Hedge g, 95%CI, −0.507 [−0.812 to −0.202], P = 0.001), spine (Hedge g, 95%CI, −0.972 [−1.537 to −0.407], P = 0.001), and miscellaneous procedures (Hedge g, 95%CI, −1.976 [−2.654 to −1.297], P < 0.0001). Pregabalin reduced 24-hour morphine consumption in gynecologic (Hedge g, 95%CI, −1.085 [−1.582 to −0.441], P = 0.001), laparoscopic cholecystectomy (Hedge g, 95%CI, –0.886 [–1.652 to –0.120], P = 0.023), orthopedic (Hedge g, 95%CI, −0.720 [−1.118 to −0.323], P < 0.0001), spine (Hedge g, 95%CI, −1.016 [−1.732 to −0.300], P = 0.005), and miscellaneous procedures (Hedge g, 95%CI, −1.329 [−2.286 to −0.372], P = 0.006). Pregabalin resulted in significant sedation in all surgical categories except ENT, laparoscopic cholecystectomy, and gynecologic procedures. Postoperative nausea and vomiting was only significant after pregabalin in miscellaneous procedures.Analgesic effects and incidence of adverse effects of using pregabalin are not equal in different surgical categories.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories

et al. 2015

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“…They had assessed sedation levels with pregabalin 75 mg, 150 mg and 300 mg against a control group and the highest sedation scores had been reported with Pregabalin 300 mg (p< 0.05). Jadeja et al, in their study, found the sedation scores to be higher in patients who were given pregabalin 150 mg in middle ear surgery [20] . Demirhan et al, found no effect on intra operative haemodynamics in patients undergoing rhinoplasty and septoplasty after preoperative pregabalin 150 mg.…”

Section: Discussionmentioning

confidence: 89%

Effect of two different dosages of pre-emptive pregabalin on the post-operative pain score after elective nasal surgeries: A prospective, randomised, double-blinded study

Shanker¹,

Subramanian²

2023

Int. J. Med. Anesthesiology

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Good perioperative pain management is beneficial for both the patient and doctor. Poor pain management can lead to delayed patient mobility, increased hospital stay and chronic pain syndrome in susceptible patients. An important concept in pain management is the idea of pre-emptive analgesia. The recommendation is to administer analgesia prior to noxious stimulus to block peripheral as well as central nociception maintaining it throughout intra and post-operative period. One drug for such use is Pregabalin, which we used in our study on 62 patients undergoing elective nasal surgeries between 2017 and 2018 to assess analgesic efficacy of 75 mg vs 150 mg of pre-emptive Pregabalin. We observed that the mean Numerical Rating Scale (NRS) score was lower in patients receiving 150 mg Pregabalin compared to those receiving 75 mg at all times, with a p value of <0.05. The former group also needed lower rescue analgesic dosage and a longer interval of first rescue analgesic dose time with comparable hemodynamic parameters in both groups.

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Use of Pregabalin as Preemptive Analgesia for Decreasing Postoperative Pain in Tympanoplasty

Teharia¹,

Rathore

2020

Indian J Otolaryngol Head Neck Surg

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Comparative study of single dose pre-emptive pregabalin vs. Placebo for post-operative pain relief in middle ear surgery

Cited by 4 publications

References 14 publications

Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories

Efficacy of Pregabalin in Acute Postoperative Pain Under Different Surgical Categories

Effect of two different dosages of pre-emptive pregabalin on the post-operative pain score after elective nasal surgeries: A prospective, randomised, double-blinded study

Use of Pregabalin as Preemptive Analgesia for Decreasing Postoperative Pain in Tympanoplasty

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