Comparative study of serum CAP activity during pregnancy in malformed and normal uterus

Blum, M

doi:10.1515/jpme.1978.6.3.165

Cited by 42 publications

(26 citation statements)

References 7 publications

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“…Some investigators suggested that fibroid uteri are less distensible than non-fibroid uteri, which leads to premature labor and delivery 11 while other noted decreased oxytocinase activity in the gravid fibroid uterus, which may result in localized increase in oxytocin levels and predisposition to premature contractions. 12 Post-partum hemorrhage (PPH) occurred in 6 (35.2%), out of these PPH occurred in 5 (29.4%) during cesarean section and 1 (5.8%) after vaginal delivery. Fibroids may distort the uterine architecture and interfere with myometrial contractions leading to uterine atony and postpartum hemorrhage.…”

Section: Maliwad Ak Et Al Int J Reprod Contracept Obstet Gynecol 20mentioning

confidence: 99%

Pregnancy outcome in patients with fibroid

Maliwad

Thaker

Shah

2014

Int J Reprod Contracept Obstet Gynecol

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Section: Maliwad Ak Et Al Int J Reprod Contracept Obstet Gynecol 20mentioning

confidence: 99%

Pregnancy outcome in patients with fibroid

Maliwad

Thaker

Shah

2014

Int J Reprod Contracept Obstet Gynecol

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“…Der genaue Mechanismus ist noch unklar. Als Hypothesen wurden eine störende Auswirkung auf die Plazentation und die uteroplazentare Zirku lation [22] sowie eine veränderte Konzentration an katalytischen Enzymen durch das Myomwachstum [23] aufgestellt.…”

Section: Abortrateunclassified

“…[16]. Eine andere Theorie geht von einer verminderten Oxygenaseaktivität in einem schwangeren Uterus myomatosus aus, was zu einer lokal erhöhten Oxytocinkonzentration und konsekutiv zu vorzeitigen Wehen führen kann [23].…”

Section: Blutungen In Der Schwangerschaftunclassified

Myome in der Schwangerschaft

Wallwiener

Gawlik

2014

Gynäkologe

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Diese Fortbildungseinheit steht Ihnen als e.CME und e.Tutorial in der Springer Medizin e.Akademie zur Verfügung. -e.CME: kostenfreie Teilnahme im Rahmen des jeweiligen Zeitschriftenabonnements -e.Tutorial: Teilnahme im Rahmen des e.Med-Abonnements ZertifizierungDiese Fortbildungseinheit ist mit 3 CMEPunkten zertifiziert von der Landesärzte-kammer Hessen und der Nord rheinischen Akademie für Ärztliche Fort-und Weiterbildung und damit auch für andere Ärzte-kammern anerkennungsfähig. Hinweis für Leser aus ÖsterreichGemäß dem Diplom-Fortbildungs-Programm (DFP) der Österreichischen Ärzte-kammer werden die in der e.Akademie erworbenen CME-Punkte hierfür 1:1 als fachspezifische Fortbildung anerkannt. Symptomatische Myome des Uterus sind ein häufiger und bedeutsamer Morbiditätsgrund für Frauen in der reproduktiven Lebensphase. Die Rate myomassoziierter Komplikationen in der Schwangerschaft wird mit etwa 10-30% angegeben, doch die Studienlage ist noch unzureichend. In der frühen Schwangerschaft können Uterusmyome mit einer erhöhten Spontanabortrate einhergehen und sind gehäuft mit Blutungen assoziiert, insbesondere wenn die Plazentation nahe am Myom stattgefunden hat. Im Verlauf der Schwangerschaft sind Schmerzen die häufigsten myomassoziierten Komplikationen, insbesondere bei Vorliegen von Myomen mit einem Größenwachstum über 5 cm im 2. und 3. Trimenon. Des Weiteren kann das Risiko in der Schwangerschaft u. a. für vorzeitige Wehen, vorzeitige Plazentalösung, Placenta praevia und Lageanomalien sowie seltener für kindliche Fehlbildungen erhöht sein. Eine Behandlung erfolgt in der Regel konservativ: Bettruhe, Flüssigkeitszufuhr, Analgesie und ggf. antibiotische Therapie. In seltenen Fällen ist jedoch operatives Vorgehen erforderlich; dann steht die Myomenukleation als Ultima Ratio im Vordergrund. Schlüsselwörter

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“…A few studies have examined how congenital uterine anomalies may induce recurrent pregnancy loss, such as by limiting the apace available for fetal growth in utero [19]. Vascularity [20], the suppression of enzymatic activity [21] , and hormone responses of the endometrium [22] in subjects with congenital uterine anomaly have been also reported as important etiologic factors inducing recurrent reproductive wastage. However, another important result of Makino' s study was that the frequency of spontaneous abortion was equally high in subjects with arcuate uterus and those with septate uterus [7,[14][15][16] (Table 4), thereby ruling out the space limitation hypothesis.…”

Section: Congenital Uterine Anomaly and Rplmentioning

confidence: 99%

Effective Treatment for Recurrent Pregnancy Loss

Makino

2010

RIB

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Abstract:Understanding the etiology of recurrent pregnancy loss (RPL) has been increasing in importance in reproductive medicine, especially in societies with low birth rates. Since the cause of human miscarriage is often complicated and multifactorial, effective treatment for the successful maintenance of pregnancy requires the comprehensive clinical management of recurrent wastages. Immunology for the maintenance of pregnancy is a very attractive field; however, the role of immunology during human gestation cannot be confirmed in couples with a history of recurrent pregnancy loss unless other clinical causes of miscarriage are especially ruled out. Balanced chromosomal rearrangements have been found at an increased frequency in couples with recurrent pregnancy loss compared with the general population. The major anomalies are Robertosonian or reciprocal translocations, while most minor variants include pericentric inversion of chromosome 9. Both major and minor anomalies result in a spontaneous abortion rate of approximately 80-90%. Though the incidences of these chromosomal abnormalities vary in reported studies, a survey indicated an incidence of 9.8% (3.9% in male partners and 5.9% in female partners) among 1,639 couples with a history of recurrent pregnancy loss. Congenital uterine anomaly resulting in a suboptimal uterine environment may influence ovum implantation and early fetal development and may be a candidate in the etiology of reproductive wastage. A review on the relation between congenital uterine anomalies and the spontaneous abortion rate concluded that a precise diagnosis of uterine cavity deformity, especially arcuate uterus, is a key issue for determining the clinical prognosis during human gestation. After establishing diagnostic criteria for uterine cavity anomaly, 278 congenital uterine anomalies were detected in a series of 2,061 hysterosalpingographies (13.5%) performed in women with a history of recurrent pregnancy loss. Among these abnormalities, the incidences of spontaneous abortion were equally high among patients with arcuate uterus and those with partial septate uterus. A few studies on abortion mechanism in patients with congenital uterine anomalies have been reported. Histological findings using CD34-positive staining indicate the lack of a blood capillary system in both the uterine septum and the fundus muscle layer. The results of metroplastic surgery on congenital uterine anomaly are also controversial. Based on our fundamental findings of the maldistribution of uterine capillaries, we performed ideal metroplastic surgery in 173 women and significantly

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Comparative study of serum CAP activity during pregnancy in malformed and normal uterus

Cited by 42 publications

References 7 publications

Pregnancy outcome in patients with fibroid

Pregnancy outcome in patients with fibroid

Myome in der Schwangerschaft

Effective Treatment for Recurrent Pregnancy Loss

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