Comparative Study of Selected Disintegrating Agents

Feinstein, W.; Bartilucci, Andrew J.

doi:10.1002/jps.2600550313

Cited by 20 publications

(2 citation statements)

References 10 publications

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“…Guar gum is another useful natural polymer that has been used widely in the pharmaceutical literature as an excipient 10–12. It is a natural water‐soluble polysaccharide, absorbing many times its weight of water, and this property is responsible for its use as an excipient in pharmaceutical, cosmetics, and food product industries.…”

Section: Introductionmentioning

confidence: 99%

Urea-formaldehyde crosslinked starch and guar gum matrices for encapsulation of natural liquid pesticide [Azadirachta Indica A. Juss. (neem) seed oil]: swelling and release kinetics

Kulkarni

Soppimath

Aminabhavi

et al. 1999

J. Appl. Polym. Sci.

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Polymeric granules were prepared by matrix encapsulation containing 20, 35 and 50% (w/w) of natural liquid pesticide viz., Azadirachta Indica A. Juss. (neem) seed oil (NSO) per dry weight of urea formaldehyde crosslinked starch (UF-St), guar gum (UF-GG) and UF-(St ϩ GG) matrices. Results of swelling and cumulative release kinetics are presented at 35°C for these matrices. The static dissolution experiments have been carried out at 35°C for seven days. The percentage cumulative release kinetic data have been analyzed using an empirical equation to study the release pattern of NSO through the polymeric membranes employed. Transport follows the Super Case II mechanism as tested by an empirical equation. It is found that the release of the active ingredient depends upon the type of the matrix and its swelling ability. The percentage loading of NSO with different matrices and their density exerted an influence on the release data. The FTIR results indicated the absence of chemical interactions between the matrices and the NSO. In the majority of cases, entrapment efficiency was generally more than 95% indicating the efficient encapsulation. Furthermore, the experimental results are discussed in terms of the nature and the combined effect of the individual matrices as well as the percentage loading of NSO.

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Section: Introductionmentioning

confidence: 99%

Urea-formaldehyde crosslinked starch and guar gum matrices for encapsulation of natural liquid pesticide [Azadirachta Indica A. Juss. (neem) seed oil]: swelling and release kinetics

Kulkarni

Soppimath

Aminabhavi

et al. 1999

J. Appl. Polym. Sci.

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“…0 conduct a series of studies on the hiiffcr cai)acity, catiotiic-exchange properties, and drug binding anti release properties of bentonite (6)(7)(8)(9)(10). M,any studies of montmorillonites as tablet disintegrants have been made, with the work of Fcinstcin and nartilucci (11) being the most recent.…”

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confidence: 99%

Some Physicochemical Properties of the Montmorillonites

Wai

Banker

1966

Journal of Pharmaceutical Sciences

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Effect of Montmorillonite on Drug Release from Polymeric Matrices

Forni

Iannuccelli

Coppi

et al. 1989

Archiv der Pharmazie

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Drug release from matrices of polyvinyl alcohol was affected by molecular weight and solubility of the drugs (either sodium salicylate or papaverine hydrochloride), and by the matrix loading. - Montmorillonite addition to the matrix formulation modified only the release constant of papaverine hydrochloride owing to drug interaction with the clay by an ionic exchange process. The kinetics exponent was affected a little bit by interaction of the drug with montmorillonite, whereas the influence of the matrix loading was more remarkable.

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Comparative Study of Selected Disintegrating Agents

Cited by 20 publications

References 10 publications

Urea-formaldehyde crosslinked starch and guar gum matrices for encapsulation of natural liquid pesticide [Azadirachta Indica A. Juss. (neem) seed oil]: swelling and release kinetics

Urea-formaldehyde crosslinked starch and guar gum matrices for encapsulation of natural liquid pesticide [Azadirachta Indica A. Juss. (neem) seed oil]: swelling and release kinetics

Some Physicochemical Properties of the Montmorillonites

Effect of Montmorillonite on Drug Release from Polymeric Matrices

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