Comparative study of room temperature stable carbetocin verses oxytocin for the prevention of PPH in caesarean section

Abstract

Introduction: PPH is one of the leading causes of maternal mortality and morbidity globally, particularly among low and middle income countries. FIGO and WHO encourages the use of heat-stable Carbetocin in resource challenged and warm climate settings. All other injectable uterotonics requires cold transport and storage at 2-8 °C. Heat-stable Carbetocin overcomes the challenges of fragile cold chain infrastructure in struggling health systems by minor modifications of the Oxytocin peptide structure. Materials and Methods: Comparative study between Carbetocin and Oxytocin. Study population -100 antenatal patients who are at high risk of developing Postpartum Hemorrhage. Results: Heat stable Carbetocin is found to be superior to Oxytocin for the prevention of Postpartum Haemorrhage with the advantage of single intravenous administration. Conclusion:Carbetocin was more haemo-dynamically stable than oxytocin. The volume of blood loss was significantly more in the Oxytocin group than in the Carbetocin group. The mean decrease in hemoglobin levels was also similar between carbetocin and oxytocin. The proportion of contracted uterus was more in the Carbetocin group than in the Oxytocin group. Carbetocin was either comparable to or advantageous over Oxytocin with regard to all the parameters studied.