Comparative study of respiratory tract immune toxicity induced by three sterilisation nanoparticles: Silver, zinc oxide and titanium dioxide

Liu, Huanliang; Yang, Dongyan; Yang, Honglian; Zhang, Hua‐Shan; Zhang, Wei; Fang, Yanjun; Liu, Zhiqing; Tian, Lei; Lin, Bei; Yan, Jun; Xi, Zhuge

doi:10.1016/j.jhazmat.2013.01.046

Cited by 102 publications

(60 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 Respiratory tract immune toxicity has also been associated with AgNPs. 16 AgNP treatment of peripheral blood mononuclear cells and human mesenchymal stem cells showed inhibition of the production of cytokines, such as IFN-c, IL-6, IL-8, IL-11, TNF-a and more weakly, IL-5. 17 In a recent in vitro study, AgNP exposure showed an induction of expression of IL-8 and stress genes in macrophages.…”

Section: Introductionmentioning

confidence: 95%

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

et al. 2015

View full text Add to dashboard Cite

The use of nanotechnology in nanoparticle-based cancer therapeutics is gaining impetus due to the unique biophysical properties of nanoparticles at the quantum level. Silver nanoparticles (AgNPs) have been reported as one type of potent therapeutic nanoparticles. The present study is aimed to determine the effect of AgNPs in arresting the growth of a murine fibrosarcoma by a reductive mechanism. Initially, a bioavailability study showed that mouse serum albumin (MSA)-coated AgNPs have enhanced uptake; therefore, toxicity studies of AgNP-MSA at 10 different doses (1-10 mg/kg b.w.) were performed in LACA mice by measuring the complete blood count, lipid profile and histological parameters. The complete blood count, lipid profile and histological parameter results showed that the doses from 2 to 8 mg (IC 50 : 6.15 mg/kg b.w.) sequentially increased the count of leukocytes, lymphocytes and granulocytes, whereas the 9-and 10-mg doses showed conclusive toxicity. In an antitumor study, the incidence and size of fibrosarcoma were reduced or delayed when murine fibrosarcoma groups were treated by AgNP-MSA. Transmission electron micrographs showed that considerable uptake of AgNP-MSA by the sentinel immune cells associated with tumor tissue and a morphologically buckled structure of the immune cells containing AgNP-MSA. Because the toxicity studies revealed a relationship between AgNPs and immune function, the protumorigenic cytokines TNF-a, IL-6 and IL-1b were also assayed in AgNP-MSA-treated and non-treated fibrosarcoma groups, and these cytokines were found to be downregulated after treatment with AgNP-MSA. Cellular & Molecular Immunology

show abstract

Section: Introductionmentioning

confidence: 95%

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

et al. 2015

View full text Add to dashboard Cite

show abstract

“…4,5 PM can exert adverse effects on the respiratory tract, which may increase the prevalence of allergic diseases associated with the physicochemistry of PM. 6,7 Recent studies have indicated that nano-scaled PM, particularly nanoparticles (NP), induce immunotoxic and allergic responses, 8,9 which represent a new and plausible health risk for healthy and asthmatic individuals.…”

Section: Introductionmentioning

confidence: 99%

Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

Chuang¹,

Hsiao²,

Wu³

et al. 2013

IJN

View full text Add to dashboard Cite

Silver nanoparticles (AgNP) have been associated with the exacerbation of airway hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy and allergic individuals are unclear. We investigated the pathophysiological responses to AgNP inhalation in a murine model of asthma. Continuous and stable levels of 33 nm AgNP were maintained at 3.3 mg/m 3 during the experimental period. AgNP exposure concomitant with ovalbumin challenge increased the enhanced pause (Penh) in the control and allergic groups. AgNP evoked neutrophil, lymphocyte and eosinophil infiltration into the airways and elevated the levels of allergic markers (immunoglobulin E [IgE] and leukotriene E 4 [LTE 4 ]), the type 2 T helper (Th2) cytokine interleukin-13 (IL-13), and oxidative stress (8-hydroxy-2′-deoxyguanosine [8-OHdG]) in healthy and allergic mice. Bronchocentric interstitial inflammation was observed after AgNP inhalation. After inhalation, the AgNP accumulated predominantly in the lungs, and trivial amounts of AgNP were excreted in the urine and feces. Furthermore, the AgNP induced inflammatory responses in the peritoneum. The inhalation of AgNP may present safety concerns in healthy and susceptible individuals.

show abstract

“…The ionic strength rises together with the increasing Ca 2+ or Na + concentrations. Divalent cations, such as Ca 2+ (occurring in lower concentrations than Na + ions), provoke electrostatic destabilization and agglomeration, with organic molecules present in the solution (Delay et al 2011, Liu et al 2013). In the aqueous environment, nAg form aggregates and networks or clusters that are infl uenced by the increasing ionic strength and the presence of surfactants or humic acids (Bae et al 2011, Ratte 1999.…”

Section: Nanosilvermentioning

confidence: 99%

“…Zn 2+ ions pose a threat to aquatic microorganisms. After entering through a cell membrane, the released Zn 2+ ions can generate reactive oxygen species (ROS) that disturb the work of microorganism organelles (Wilson et al 2007, Liu et al 2013. The antibacterial activity of ZnO-NPs depends on the aggregation, size and concentration.…”

Section: Metal Oxide Nanoparticles Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Inorganic nanomaterials in the aquatic environment: behavior, toxicity, and interaction with environmental elements

Krzyżewska¹,

Kyzioł-Komosińska²,

Rosik-Dulewska³

et al. 2016

Archives of Environmental Protection

View full text Add to dashboard Cite

Abstract:The aim of this paper is to present characteristics, toxicity and environmental behavior of nanoparticles (NPs) (silver, copper, gold, zinc oxide, titanium dioxide, iron oxide) that most frequently occur in consumer products. In addition, NPs are addressed as the new aquatic environmental pollutant of the 21 st century. NPs are adsorbed onto particles in the aquatic systems (clay minerals, fulvic and humic acids), or they can adsorb environmental pollutants (heavy metal ions, organic compounds). Nanosilver (nAg) is released from consumer products into the aquatic environment. It can threaten aquatic organisms with high toxicity. Interestingly, copper nanoparticles (Cu-NPs) demonstrate higher toxicity to bacteria and aquatic microorganisms than those of nanosilver nAg. Their small size and reactivity can cause penetration into the tissues and interfere with the metabolic systems of living organisms and bacterial biogeochemical cycles. The behavior of NPs is not fully recognized. Nevertheless, it is known that NPs can agglomerate, bind with ions (chlorides, sulphates, phosphates) or organic compounds. They can also be bound or immobilized by slurry. The NPs behavior depends on process conditions, i.e. pH, ionic strength, temperature and presence of other chemical compounds. It is unknown how NPs behave in the aquatic environment. Therefore, the research on this problem should be carried out under different process conditions. As for the toxicity, it is important to understand where the differences in the research results come from. As NPs have an impact on not only aquatic organisms but also human health and life, it is necessary to recognize their toxic doses and know standards/regulations that determine the permissible concentrations of NPs in the environment.Unauthenticated Download Date | 5/12/18 7:36 AM

show abstract

Comparative study of respiratory tract immune toxicity induced by three sterilisation nanoparticles: Silver, zinc oxide and titanium dioxide

Cited by 102 publications

References 28 publications

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

Inorganic nanomaterials in the aquatic environment: behavior, toxicity, and interaction with environmental elements

Contact Info

Product

Resources

About