Comparative study of regional cerebral blood flow values measured by Xe CT and Xe SPECT

Abstract

Comparative study of regional cerebral blood flow values measured by Xe CT and Xe SPECT. Acta Neurol Scand 1996: Suppl. 166: 13-16The regional cerebral blood flow (rBCF) values measured by stable xenonenhanced computed tomography (Xe XT) and by radioactive xenon-1 33 single photon emission computed tomography (Xe SPECT) were compared in 16 patients with cerebral infarct. On the non-lesion side Xe SPECT recorded 10.7% higher rCBF values than Xe CT in the anterior cerebral artery territory, while Xe CT recorded 9.6% higher values than Xe SPECT in the middle cerebral artery territory. These differences were not statistically significant. Although the rCBF values were almost the same, no correlation was found between the two methods in the posterior cerebral artery territory and the basal ganglia. Only hemispheric CBF on the non-lesion side showed the same value and a good correlation between the Xe CT and the Xe SPECT. There was a good correlation in the hemispheric CBF values on the lesion side, too. The difference of rCBF between the non-lesion side and the lesion side was expressed smaller in the Xe SPECT than in the Xe CT. This is in agreement with the previous reports that Xe SPECT overestimates the flow in the low flow areas. The higher rCBF values in the anterior cerebral artery territory measured by the Xe SPECT was ascribed to the artifact from the radioactivities in the inhalation mask and the air passages as reported previously. In conclusion, there is no good correlation between the rCBF values measured by the Xe CT and by the Xe SPECT. Only hemispheric CBF shows a good correlation between the two methods.Stable xenon-enhanced computed tomography (Xe CT) is a method of quantitative measurement of regional cerebral blood flow (rCBF), and it is now used as one of the routine examinations in neurological and neurosurgical patients. Two-dimensional quantitative measurement of rCBF using radioactive tracer, xenon-133 ( 133Xe), has been the standard method sine the 1960s. Three-dimensional measurement by '33Xe single photon emission computed tomography (Xe SPECT) was developed for clinical use around 1980 (10, 14), and clinical application of the Xe CT was also started around that time (2, 4, 12). However, comparative study between the Xe CT and the Xe SPECT has been few. We compared the rCBF values measured by the Xe CT and those measured by the Xe

The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test–retest study

“…Larger values are often reported in ASL and Xenon based methods (Blauenstein et al, 1977; Hermes et al, 2007; Matsuda et al, 1996; Wintermark et al, 2001). This could be explained in part by the regularization technique used in the QUASAR method during quantification, which does generally underestimate CBF (Petersen et al, 2006a).…”

Editorial - Neuromonitoring: The Concept of Targeted Therapy Revisited

“…Practically, this has found to not be a concern, as the flow activation is minimal and occurs later than the period of measurement. The accuracy of the xenon/ CT method has undergone rigorous cross-correlation assessment with destructive (microspheres [3], iodoantipyrine [4]), and in vivo (xenon133 [5], PET [6], thermal dilution flow probes [7]) CBF technologies.…”

Peripheral Vascular Noninvasive Measurements

“…In one clinically important example, it has been found that the detected X ray CT signal changes in a quantifiable manner following inhalation of a gas mixture containing appreciable levels of nonradioactive isotopes of xenon (typically 33% Xe and 67% O 2 , or 30% Xe, 60% O 2 , 10% air) (75)(76)(77). A variety of techniques based on this phenomenon, and referred to as stable xenon-enhanced CT or s Xe-CT, were subsequently developed.…”