Comparative study of quality of life, anxiety, depression, and fatigue among patients with neuromyelitis optica spectrum disorder and multiple sclerosis: The first report from Iran

Barzegar, Mahdi; Badihian, Shervin; Mirmosayyeb, Omid; Ashtari, Fereshteh; Jamadi, Maryam; Emami, Shohreh; Jahani, Leila; Safavi, A.R.A; Shaygannejad, Vahid

doi:10.1016/j.msard.2018.04.009

Cited by 48 publications

(38 citation statements)

References 30 publications

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“…In our study, the highest levels of depression, stress, and anxiety were observed in married patients, which is in line with the results of Alsadi et al(2015) [20]. However, Barzegar et al (2017) found no significant association between marital status and depression among MS patients in Iran [22]. It seems that married patients undergo more mental stress than single patients due to impaired family responsibilities, which manifests as depression, anxiety, and stress.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of anxiety, depression, and stress in patients with multiple sclerosis in Kermanshah-Iran: a cross-sectional study

2020

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Background: Multiple sclerosis (MS) is a chronic disease that decreases the physical ability and affects the mental health of the patients. This descriptive-analytical study investigated the prevalence of depression, anxiety and stress in MS patients. Methods: A total of 87 MS patients were recruited in this study through simple random sampling method using a random number table. Data were collected by Depression, Anxiety, and Stress Scale-21 (DASS-21) and analyzed by descriptive and analytical statistics. Results: The mean age of the patients was 35.5 ± 9.2 years. Of them, 41 (47.1%) had moderate depression, 34 (39.1%) had moderate anxiety, and 39 (44.8%) had moderate stress. There was a significant relationship between depression and job, education, and economic status of the participants. There was also a significant association between the participants' economic status and anxiety. There was no significant relationship between stress and any of the variables. Conclusion: Given the relatively high prevalence of anxiety, depression, and stress in MS patients as well as the significant relationship between their economic status and depression and anxiety, interventional measures are required to be taken to decrease their problems and to provide a favorable ground for their employment. Periodic examinations by psychologists / psychiatrists and treatment of patients with symptoms of stress, anxiety and depression are also essential.

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Section: Discussionsupporting

confidence: 91%

Prevalence of anxiety, depression, and stress in patients with multiple sclerosis in Kermanshah-Iran: a cross-sectional study

2020

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“…In the neuromyelitis optica spectrum disorders (NMOSD) clinic, fatigue is also a frequent complaint. This observation is supported by a few studies to date that seem to suggest that fatigue in NMOSD is as prevalent and as severe as that seen in MS 9‐12 . There are a number of potential pathogenic factors that could contribute to fatigue in NMOSD such as astrocytic injury, demyelination, and axonal loss, as well as secondary contributors like disability, pain, depression, and side effects of medications.…”

Section: Introductionmentioning

confidence: 67%

“…7,8 In the neuromyelitis optica spectrum disorders (NMOSD) clinic, fatigue is also a frequent complaint. This observation is supported by a few studies to date that seem to suggest that fatigue in NMOSD is as prevalent and as severe as that seen in MS. [9][10][11][12] There are a number of potential pathogenic factors that could contribute to fatigue in NMOSD such as astrocytic injury, demyelination, and axonal loss, as well as secondary contributors like disability, pain, depression, and side effects of medications. Some studies have identified a correlation between fatigue and depression in NMOSD, 9,10,13 however the small number of patients (range 33-40) within these studies mean that adjustment for covariates to explore independent contributors of fatigue was not possible.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have identified a correlation between fatigue and depression in NMOSD, 9,10,13 however the small number of patients (range 33-40) within these studies mean that adjustment for covariates to explore independent contributors of fatigue was not possible. 9,10,[12][13][14] Furthermore, the analyses within these studies were performed by combining not only patients who were aquaporin-4-antibody (AQP4-Ab) positive but also 'seronegative' NMOSD patients, 9,[11][12][13][14][15] which is likely to comprise different pathological conditions including myelin oligodendrocyte glycoprotein-antibody (MOG-Ab) disease, atypical MS and other autoimmune and connective tissue diseases. We have previously noted that there are different drivers of pain in AQP4-Ab disease compared to antibody negative NMOSD, 16 thus is important to separate different diseases when trying to understand the drivers of symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…There are a number of potential pathogenic factors that could contribute to fatigue in NMOSD such as astrocytic injury, demyelination, and axonal loss, as well as secondary contributors like disability, pain, depression, and side effects of medications. Some studies have identified a correlation between fatigue and depression in NMOSD, 9,10,13 however the small number of patients (range 33–40) within these studies mean that adjustment for covariates to explore independent contributors of fatigue was not possible 9,10,12‐14 . Furthermore, the analyses within these studies were performed by combining not only patients who were aquaporin‐4‐antibody (AQP4‐Ab) positive but also ‘seronegative’ NMOSD patients, 9,11‐15 which is likely to comprise different pathological conditions including myelin oligodendrocyte glycoprotein‐antibody (MOG‐Ab) disease, atypical MS and other autoimmune and connective tissue diseases.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with fatigue in CNS inflammatory diseases with AQP4 and MOG antibodies

Yeo

Passos

Muhammed

et al. 2020

Ann Clin Transl Neurol

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Objective Fatigue is a common and disabling symptom amongst people with multiple sclerosis, however it has not been compared across the central nervous system (CNS) inflammatory diseases associated with aquaporin‐4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibodies (Ab). We explored the factors associated with fatigue within and across the two diseases, and compared fatigue levels between them. Methods We performed a cross‐sectional study of 90 AQP4‐Ab and 44 MOG‐Ab patients. Fatigue was assessed using the Modified Fatigue Impact Scale (MFIS). Clinical, demographic, and psychometric (anxiety, depression, pain) data were used as independent variables. Multivariable linear regression was used to identify significant independent variables associated with fatigue within and across the two diseases. Results Within AQP4‐Ab patients, age (P = 0.002), disease duration (P = 0.004), number of clinical attacks (P = 0.001), disability (P = 0.007), pain interference (P < 0.001), anxiety (P = 0.026), and depression (P < 0.001) were significant independent variables. Interestingly, disease duration had a negative association with fatigue (P = 0.004). Within MOG‐Ab patients, pain interference score (P < 0.001) and anxiety (P = 0.001) were significant independent variables. Although fatigue was worse in AQP4‐Ab patients compared to MOG‐Ab patients (P = 0.008) in all patients as well as in those who ever had transverse myelitis (P = 0.023), this was driven by the differences in age, disability and pain interference rather than antibody subtype itself. Interpretation Multiple factors, but not the antibody specificity, appear to contribute to fatigue in antibody positive CNS inflammatory diseases. A multifaceted treatment approach is needed to better manage the physical, cognitive, and psychosocial aspects of fatigue in these patients.

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Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders

et al. 2021

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Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune inflammatory conditions that primarily target the optic nerves, spinal cord, brainstem, and occasionally the cerebrum. NMOSD is characterized by recurrent attacks of visual, motor, and/or sensory dysfunction that often result in severe neurological deficits. In recent years, there has been a significant progress in relapse treatment and prevention but the residual disability per attack remains high. Although symptomatic and restorative research has been limited in NMOSD, some therapeutic approaches can be inferred from published case series and evidence from multiple sclerosis literature. In this review, we will discuss established and emerging therapeutic options for symptomatic treatment and restoration of function in NMOSD. We highlight NMOSD-specific considerations and identify potential areas for future research. The review covers pharmacologic, non-pharmacologic, and neuromodulatory approaches to neuropathic pain, tonic spasms, muscle tone abnormalities, sphincter dysfunction, motor and visual impairment, fatigue, sleep disorders, and neuropsychological symptoms. In addition, we briefly discuss remyelinating agents and mesenchymal stem cell transplantation in NMOSD.

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Comparative study of quality of life, anxiety, depression, and fatigue among patients with neuromyelitis optica spectrum disorder and multiple sclerosis: The first report from Iran

Cited by 48 publications

References 30 publications

Prevalence of anxiety, depression, and stress in patients with multiple sclerosis in Kermanshah-Iran: a cross-sectional study

Prevalence of anxiety, depression, and stress in patients with multiple sclerosis in Kermanshah-Iran: a cross-sectional study

Factors associated with fatigue in CNS inflammatory diseases with AQP4 and MOG antibodies

Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders

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