Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats

Zhu, Mo; Feng, Weiyue; Wang, Bing; Wang, Tian Cheng; Gu, Yi Qun; Wang, Meng; Wang, Yun; Ouyang, Hong; Zhao, Yu; Chai, Zhifang

doi:10.1016/j.tox.2008.02.011

Cited by 241 publications

(135 citation statements)

References 26 publications

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“…Histopathology of the cell, tissue or organ after exposure is used to determine the toxicity level caused by a nanoparticle [94]. Histopathology examination has been used to nanoparticles' exposed tissues such as lung, eyes, brain, liver, kidneys, heart and spleen [93,95]. The advancement of toxicity assessment includes use of micro-electrochemistry and microfluidics [96].…”

Section: In Vivo Toxicity Assessment Methodsmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: In Vivo Toxicity Assessment Methodsmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…Starting from a concentration of 50 μg diesel exhaust particles (DEPs), Nemmar et al observed acute increased thrombosis formation in the right femoral vein and artery in hamsters [53]. On the contrary, Zhu et al reported an increased PT and aPTT compared to the control, 30 days after intratracheal instillation of 0.8 mg/kg bw ferric oxide NPs in rats [54]. Yoshida et al also reported an increased aPTT and marginally increased PT after the intranasal administration of 0.5 mg 30 nm and 70 nm SiO 2 NPs during 7 days [55].…”

Section: Nanoparticle-induced Hemostasis Effectsmentioning

confidence: 99%

Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice

Luyts

Smulders

Napierska

et al. 2014

Particle and Fibre Toxicology

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“…The concentrations of total glutathione (T-GSH), reduced glutathione (GSH) and oxidized glutathione (GSSG) were measured by an enzymatic method according to the commercial assay kit procedure (Beyotime Institute of Biotechnology, Jiangsu, China) as previously described (Zhu et al, 2008). Briefly, T-GSH was assayed using the 5, 5-dithio-bis (2-nitrobenzoic) acid (DTNB)-GSSG reductase recycling.…”

Section: Detection Of Glutathionementioning

confidence: 99%