Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice

Abstract

Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.

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“…There were no significant changes in blood biochemical parameters, including alanine transaminase (ALT), aspartate transaminase (AST), lactic dehydrogenase (LDH), creatinine (CREA), and uric acid (UA), as well as hematoxylin and eosin (H&E) staining images of main organs, including the heart, liver, spleen, lung, and kidney (Figure A–C). However, ALT and AST, as well as liver function markers, were significantly higher in the blood of 10 -treated nude mice (300 mg/kg), indicating the hepatic injury . Amazingly, compared with the control group, H&E of liver tissues did not show significant changes in the 10 -treated group (25 mg/kg).…”

“…However, ALT and AST, as well as liver function markers, were significantly higher in the blood of 10-treated nude mice (300 mg/kg), indicating the hepatic injury. 48 Amazingly, compared with the control group, H&E of liver tissues did not show significant changes in the 10-treated group (25 mg/kg). The results suggested that a low dose (25 mg/kg) of compound 10 was safe for biomedical application without serious toxicity and adverse events, while high dosages (300 mg/kg) were toxic.…”