Comparative Study of Pretreatment With Rocuronium and Vecuronium in Post Succinylcholine Fasciculation, Intubation Condition and Myalgia

Abstract

Succinylcholine has quicker onset of action, reliable and excellent intubating conditions with shorter duration but has undesirable side effects as fasciculation, rise intraocular pressure, rise in intragastric pressure and subsequent vomiting and regurgitation hyperkalaemia, rise serum CPK levels, myalgia and myoglobinuria. It is contraindicated in anticipated difficult intubation, severe kidney and liver disease, trauma, pregnancy, etc. Many methods were tried to decrease these side effects of succinylcholine by many scientists. Pretreatment with non-depolarizing muscle relaxant is one of that which found to be successful. In the present study, Rocuronium and Vecuronium were tried to evaluate their efficacy in reducing post succinylcholine fasciculation, intubating conditions, serum potassium and CPK, myalgia and myoglobin; 150 patients were divided into three groups according to administration normal saline Rocuronium, Vecuronium as pretreatment before Succinylcholine where general anaesthesia administration was essential. It was observed that pretreatment with Rocuronium and Vecuronium significantly reduced incidence and severity of fasciculation, better intubating conditions, no change in serum potassium and CPK levels, reduction in Myalgia and no change in myoglobin postoperatively. Rocuronium was found to be better than Vecuronium in all respects to minimize side effects of Succinylcholine.

Effect of Non-depolarizing Muscle Relaxants Rocuronium Versus Vecuronium in the Assessment of Post-Succinylcholine Complications in Surgeries Under General Anesthesia: A Randomized Double-Blind Study at a Tertiary Care Hospital

“…In a study conducted by Joshi et al [30], the incidence of mild to moderate myalgia was found to be higher in the VEC group when compared to the ROC group. Our findings concur with those of O'Sullivan et al [36] and Erkola [14].…”

“…In a study conducted by Joshi et al [30], the incidence of fasciculations was 24% with ROC and 48% with VEC, with a 100% incidence rate in the control group (normal saline). In a study by Abbas et al [31] using 0.1 mg/kg of ROC as pretreatment, 100% (mild to severe) fasciculations were noticed in the saline group as compared to 13.3% (mild) in the ROC group.…”