Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model

Wilms, Christian; Müeller, Lars; Lenk, Christian; Wittkugel, Oliver; Helmke, K.; Krupski-Berdien, G.; Rogiers, Xavier; Bröering, Dieter C.

doi:10.1097/sla.0b013e31816a9d7c

Cited by 69 publications

(58 citation statements)

References 28 publications

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“…23 The finding of superior hypertrophy was confirmed by another research group in an animal model and in human use. 24,25 In addition, the inflicted trauma to the patient is much lower in PVE owing its minimally invasive nature.…”

Section: Discussionmentioning

confidence: 99%

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Identification of cofactors influencing hypertrophy of the future liver remnant after portal vein embolization—the effect of collaterals on embolized liver volume

Zeile¹,

Bakal

Volkmer³

et al. 2016

The British Journal of Radiology

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Objective: The purpose of this retrospective study was to monitor hypertrophy of future liver remnant following portal vein embolization (PVE) before planned extended right hepatectomy. However, because individual responses to PVE are highly variable, our focus was to identify cofactors of successful hypertrophy. Methods: 28 patients with primary or secondary liver tumours, mean age 64.1 6 12.9 years, underwent PVE. Volumetric analysis of hypertrophy before and after PVE (median 39.0 6 15.7 days) was performed. The embolized liver segments were investigated for occurrence of reperfusion of their portal branches. Blood parameters before PVE were additionally investigated. Results: Patients were divided into responders (21/28) and non-responders (7/28) by post-PVE standardized future liver remnant being above or below 25%, respectively. No significant differences between the groups were found regarding biometric and volumetric parameters before PVE. In the entire group after PVE, the mean absolute increase of Segments 2 and 3 was 196.0 6 84.7 cm 3 and the median relative increase was 46.6 6 98.8%. The formation of left to right hepatic portoportal collaterals exhibited a negative correlation to successful hypertrophy (p 5 0.004) as well as low plasma total protein (p 5 0.019). Successful embolization of Segment IV showed only a trend to significance (p 5 0.098). Conclusion: Cofactors associated with a favourable outcome regarding hypertrophy were the absence of collaterals in the control CT scans and high plasma total protein. Advances in knowledge:Portoportal collaterals negatively influence hypertrophy after PVE. On the other hand, plasma total protein is a positive prognostic indicator on hypertrophy of the liver in our cohort.

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Section: Discussionmentioning

confidence: 99%

“…38 However, changes in macroarchitecture have been reported earlier in an animal model. 25 These findings could imply that earlier CT follow-up has to be made. If collaterals are detected in these early controls paired with a slow increase in FLR, e.g.…”

mentioning

confidence: 99%

Identification of cofactors influencing hypertrophy of the future liver remnant after portal vein embolization—the effect of collaterals on embolized liver volume

Zeile¹,

Bakal

Volkmer³

et al. 2016

The British Journal of Radiology

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“…Removal of a kidney, a part of the liver, a salivary gland or a plaintive gland causes an increase in the proliferative activity of the remaining organ or gland (13)(14)(15)(16)(17)(18)(19)(20). A factor appears in blood serum which enhances cell proliferation as early as 12 h after small bowel resection (21).…”

Section: Discussionmentioning

confidence: 99%

Induction of resistance to murine tumor development is associated with alterations in the glycosylation of blood serum proteins

Доненко

Ziganshin²,

Ситдикова³

et al. 2009

Mol Med Rep

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Abstract. The phenomenon of accelerated metastatic tumor growth following the removal of the primary tumor is a major reason for cancer relapse, caused by underlying mechanisms that are not as yet understood. We hypothesized that a growthstimulating factor is produced by the tumor-bearing host. This assumption was confirmed by an experiment involving the removal of a primary tumor (ascitic and solid Ehrlich carcinoma cells) from C57B1/6 mice, after which accelerated proliferation was observed in the remaining tumor cells. Peripheral blood leukocytes (PBLCs), spleen leukocytes (SLCs) and peritoneal cells (PCs) were transferred from donor animals with their tumors removed to healthy animals, along with tumor cells. This procedure suppressed tumor growth in 20-40% of the recipient animals when PBLCs, SLCs or PCs were collected 6-8 h after the removal of the tumor. In a second experiment, PBLCs, SLCs or PCs were injected into the mice, and the tumor cells were inoculated 14 days later. Resistance to tumor development occurred within the same time frame (6-8 h) but was more pronounced (60-80%) than in the previous experiment. Ehrlich carcinoma cells affected the binding of FITC-labeled blood serum glycoproteins in a timedependent manner. Mass spectrometry revealed that the spectrum of glycopeptides in blood serum taken from control mice differed from the spectra of glycopeptides obtained from mice 8-24 h after the removal of Ehrlich carcinoma cells. Comparable effects were also observed with Cloudman S91 melanoma. In conclusion, the inhibition of tumor growth mediated by donor cells (PBLCs, SLCs and PCs) transferred from operated donor animals to recipient animals indicates the existence of a tumor-regulating factor in blood serum. This phenomenon is associated with characteristic alterations in the glycosylation of blood serum proteins.

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“…Removal of a kidney, a part of the liver, a salivary gland or a plaintive gland causes an increase in the proliferative activity of the remaining organ or gland ( Urie et al, 2007 ;Haxhija et al, 2007;Martin et al, 2008;Juno et al, 2002;Nelson et al, 2002;Vlastos et al, 2008;Aussilhou et al, 2008;Wilms et al, 2008). A factor appears in blood serum which enhances cell proliferation as early as 12 h after small bowel resection (Juno et al, 2003.).…”

Section: (Patho)physiological Processes Of Quantitative Organ (Tissuementioning

confidence: 99%

Quantitative Regulation of Melanoma Growth in the Host by Tumor-Specific Serpins in Blood Serum is a Main Reason for Inefficient Tumor Treatment

Доненко¹,

Киселевский²,

Efferth³

2011

Breakthroughs in Melanoma Research

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Comparative Study of Portal Vein Embolization Versus Portal Vein Ligation for Induction of Hypertrophy of the Future Liver Remnant Using a Mini-Pig Model

Cited by 69 publications

References 28 publications

Identification of cofactors influencing hypertrophy of the future liver remnant after portal vein embolization—the effect of collaterals on embolized liver volume

Identification of cofactors influencing hypertrophy of the future liver remnant after portal vein embolization—the effect of collaterals on embolized liver volume

Induction of resistance to murine tumor development is associated with alterations in the glycosylation of blood serum proteins

Quantitative Regulation of Melanoma Growth in the Host by Tumor-Specific Serpins in Blood Serum is a Main Reason for Inefficient Tumor Treatment

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