Comparative Study of Physicochemical Properties and Biocompatibility (L929 and MG63 Cells) of TiN Coatings Obtained by Plasma Nitriding and Thin Film Deposition

Abstract

Ti6Al4V is one of the most lightweight, mechanically resistant, and appropriate for biologically induced corrosion alloys. However, surface properties often must be tuned for fitting into biomedical applications, and therefore, surface modification is of paramount importance to carry on its use. This work compares the interaction between two different cell lines (L929 fibroblasts and osteoblast-like MG63) and medical grade Ti6Al4V after surface modification by plasma nitriding or thin film deposition. We studied the adhesion of these two cell lines, exploring which trends are consistent for cell behavior, correlating with osseointegration and in vivo conditions. Modified surfaces were analyzed through several physicochemical characterization techniques. Plasma nitriding led to a more pronounced increase in surface roughness, a thicker aluminum-free layer, made up of diverse titanium nitride phases, whereas thin film deposition resulted in a single-phase pure titanium nitride layer that leveled the ridged topography. The selective adhesion of osteoblast-like cells over fibroblasts was observed in nitrided samples but not in thin film deposited films, indicating that the competitive cellular behavior is more pronounced in plasma nitrided surfaces. The obtained coatings presented an appropriate performance for its use in biomedical-aimed applications, including the possibility of a higher success rate in osseointegration of implants.

Bio-Tribology and Corrosion Behaviors of a Si- and N-Incorporated Diamond-like Carbon Film: A New Class of Protective Film for Ti6Al4V Artificial Implants

“…In addition, the tribological performances of Ti6Al4V are poor. Therefore, Ti6Al4V for permanent implant applications is restricted due to the release of vanadium and aluminum ions in the process of corrosion and wear. − Aluminum ions can result in discomfort or pain , in the vicinity of the implants, and vanadium in the alloys is also considered cytotoxic, which becomes an urgent problem to be solved, and scientists devote a great deal of energy and money to promoting it. To date, one approach is that some metal elements with good compatibility, such as Nb and Zr, − have been introduced into titanium alloys to obtain titanium base alloy without V and Al elements.…”

Novel Application of 3D Scaffolds of Poly(E-Caprolactone)/Graphene as Osteoinductive Properties in Bone Defect

“…Myosin proteins interact with actin filaments to produce two distinct forms of movement. 28 29 To begin, myosin generates force between actin filaments, causing contractions that pull the rear of moving cells up, pinching cells in half, and reshaping them into tissues. 30 Muscle cells are contracted using a similar manner.…”

Research progress of metal biomaterials with potential applications as cardiovascular stents and their surface treatment methods to improve biocompatibility

“…Many surface treatment methods currently exist, including chemical methods [ 68 ] and physical methods [ 69 ]. Physical methods consist of milling [ 70 ], laser [ [71] , [72] , [73] ], sandblasting [ 74 , 75 ], and electrical discharge machining (EDM) [ 76 , 77 ], while chemical methods include acid [ 78 ] and alkali treatment [ 79 , 80 ], nitriding [ 81 , 82 ], and plasma treatment [ 83 , 84 ]. In addition, some electrochemical methods are available, such as electropolishing [ 85 , 86 ], electrolytic polishing [ 87 , 88 ], anodic oxidation [ 89 , 90 ], and micro-arc oxidation (MAO, also known as plasma electrolytic oxidation) [ 80 , 91 ].…”