2014
DOI: 10.3906/sag-1104-54
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Comparative study of photodynamic therapy monotherapy versus triplemanagement in age-related macular degeneration

Abstract: Aim: To compare the effectiveness of photodynamic therapy (PDT) and PDT combined with intravitreal triamcinolone (IVTA) and vascular endothelial growth factor inhibition (anti-VEGF) in age-related macular degeneration (AMD).Materials and methods: Eighty eyes of 80 patients diagnosed with choroidal neovascularization (CNV) caused by AMD were included in the study. PDT was carried out on 40 eyes in group I, and PDT combined with 4 mg IVTA and anti-VEGF (1.25 mg bevacizumab in 20 eyes, 0.3 mg pegaptanib sodium in… Show more

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Cited by 4 publications
(3 citation statements)
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References 27 publications
(41 reference statements)
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“…Nowadays, nAMD is treated by routine intraocular injections of anti-VEGF agents [77][78][79][80][81][82][83], and to some extent by photodynamic therapy and thermal laser [84,85]. The use of intravitreal anti-VEGF agents has revolutionized the treatment of nAMD with pegaptanib being the first approved anti-VEGF agent.…”
Section: Treatment Of Amdmentioning
confidence: 99%
“…Nowadays, nAMD is treated by routine intraocular injections of anti-VEGF agents [77][78][79][80][81][82][83], and to some extent by photodynamic therapy and thermal laser [84,85]. The use of intravitreal anti-VEGF agents has revolutionized the treatment of nAMD with pegaptanib being the first approved anti-VEGF agent.…”
Section: Treatment Of Amdmentioning
confidence: 99%
“…More recently, GCs has been used in combination with anti-VEGF (Vakalis et al, 2015; Calvo et al; and 2015, Lim et al 2015) or photodynamic monotherapy (Selım et al, 2014). These combinations have been shown to have superior results than either treatment alone.…”
Section: Introductionmentioning
confidence: 99%
“…Clinical use of this drug product is facilitated by its intravenous infusion using sterile water for injection followed by the application of non-thermal red light. In addition, verteporfin combination with anti-vascular endothelial growth factor therapeutics and steroid drugs like triamcinolone acetonide demonstrated superior efficacy in decreasing the frequency and number of treatment sessions and improved visual prognosis [ 118 , 119 ]. In the same context, loading of a dendritic porphyrin into polyethylene glycol-block-poly(L-lysine) micelles was accomplished in an attempt for age-related macular degeneration treatment.…”
Section: Light-responsive Drug Delivery Systemsmentioning
confidence: 99%