Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering

Ródenas-Rochina, Joaquín; Ribelles, J.L. Gómez; Lebourg, Myriam

doi:10.1007/s10856-013-4878-5

Cited by 67 publications

(61 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the electrospun membrane containing 10% HA showed a marked proliferation with respect to the pure PCL mat. A similar behavior was obtained by Ródenas et al [71] using PCL scaffolds with different content of HA. The membrane with BgP content show the lowest signal of viability after 14 days, however no significant differences were found between the membranes with the same content of particles of either 5% BgP or 5% HA in all the culture times evaluated.…”

Section: Figuresupporting

confidence: 86%

Poly(ɛ-caprolactone) Electrospun Scaffolds Filled with Nanoparticles. Production and Optimization According to Taguchi's Methodology

Silva

Luz

Gamboa-MartÍnez

et al. 2014

Journal of Macromolecular Science, Part B

View full text Add to dashboard Cite

Abstract. Polycaprolactone scaffolds were produced by electrospinning. Polymeric solutions in a mix of dichloromethane and dimethylformamide were electrospun to form fibers in the sub-micron range. Physical properties of the polycaprolactone solutions were characterized with respect to density, viscosity, conductivity and surface tension. Processing was optimized following Taguchi's methodology to select the set of processing parameters that resulted in producing fibers with the smallest diameters, minimum number of defects and with the narrowest distribution of fiber diameter. Morphology of electrospun fibers was qualitatively and quantitatively analyzed for the different sets of processing parameters. The optimum conditions found to electrospun polycaprolactone were used to process polycaprolactone solutions containing nano-particles of hydroxyapatite or bioactive glass. Bioactivity of nano-composite electrospun membranes in simulated body fluid was analyzed and biological response was tested by assessing proliferation and viability of MT3C3-E1 preosteoblasts cultured on polycaprolactone and its nanocomposite membranes.

show abstract

Section: Figuresupporting

confidence: 86%

Poly(ɛ-caprolactone) Electrospun Scaffolds Filled with Nanoparticles. Production and Optimization According to Taguchi's Methodology

Silva

Luz

Gamboa-MartÍnez

et al. 2014

Journal of Macromolecular Science, Part B

View full text Add to dashboard Cite

show abstract

“…Using a similar HA precipitation-based strategy, porous HA-gelatin microparticles were fabricated with fairly uniform size distribution in a one pot reaction using vegetable oil rather than harsh organic solvents (Ródenas-Rochina et al 2013). Alternatively, HAgelatin microparticles were synthesised by the addition of granulated coralline HA to a solution of gelatin, followed by dropwise addition of the mixture to a polymethylmethacrylate (PMMA) dispersion and glutaraldehyde cross-linking (Farbod et al 2014).…”

Section: Gelatin Mixed With Ceramicsmentioning

confidence: 99%

Recent advances in the use of gelatin in biomedical research

2015

View full text Add to dashboard Cite

The biomacromolecule, gelatin, has increasingly been used in biomedicine-beyond its traditional use in food and cosmetics. The appealing advantages of gelatin, such as its cell-adhesive structure, low cost, off-the-shelf availability, high biocompatibility, biodegradability and low immunogenicity, among others, have made it a desirable candidate for the development of biomaterials for tissue engineering and drug delivery. Gelatin can be formulated in the form of nanoparticles, employed as size-controllable porogen, adopted as surface coating agent and mixed with synthetic or natural biopolymers forming composite scaffolds. In this article, we review recent advances in the versatile applications of gelatin within biomedical context and attempt to draw upon its advantages and potential challenges.

show abstract

“…The scaffolds were prepared by a dual technique of freeze extraction combined with porogen leaching [36] of 15 weight % solutions of PCL and PLLA in dioxane. In order to avoid the blend ratio where phases are cocontinuous (which in previous experiments, [37], has proven to lead to a very weak structure when produced as a macroporous scaffold), PLLA/PCL weight ratios of 80/20 and 20/80 were used.…”

Section: Scaffold Preparationmentioning

confidence: 99%

Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL porous scaffolds

Ródenas-Rochina

Vidaurre

Cortázar

et al. 2015

Polymer Degradation and Stability

Self Cite

View full text Add to dashboard Cite

Poly(L-lactic acid)(PLLA)/poly(ε-caprolactone)(PCL)/hydroxyapatite(HAp) composites appear as promising materials for healing large bone defects. Highly porous PLLA/PCL scaffolds, 80/20, 20/80 weight ratios, porosity >85%, were prepared by a dual technique of freeze extraction and porogen leaching, with and without HAp. A double pore structure was obtained, with interconnected macroporosity together with interconnected microporosity. Elastic modulus and yield strength of as-synthesized scaffolds were higher for PLLA rich blends and including the inorganic phase does not lead to a mechanical strengthening in these materials. Subsequent long-term (78 weeks = 1.5 years) hydrolytic degradation behavior was investigated in terms of the samples´ mechanical properties, molecular weight (M w ), mass changes, thermal characteristics, X-ray Diffraction and Thermogravimetric Analysis. Elastic modulus and yield strength of as-synthesized scaffolds were higher for PLLA rich blends and including the inorganic phase does not lead to a mechanical strengthening in these materials. Nevertheless, after 30 weeks of degradation, PLLA rich scaffolds lost more than half of their strength and rigidity. On the contrary, the densification modulus of the PLLA based blends increased with degradation time, whereas PCL-based blends had a relatively constant densification modulus. PCL-based samples showed lower hydrolysis coefficients k than PLLA-based samples, as expected from the higher density of ester bonds in the latter. Interestingly, although including HAp leads to a lower hydrolysis coefficient k in PCL rich samples, it increases k in the PLLAbased sample, which is consistent with the other results obtained.

show abstract

Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering

Cited by 67 publications

References 57 publications

Poly(ɛ-caprolactone) Electrospun Scaffolds Filled with Nanoparticles. Production and Optimization According to Taguchi's Methodology

Poly(ɛ-caprolactone) Electrospun Scaffolds Filled with Nanoparticles. Production and Optimization According to Taguchi's Methodology

Recent advances in the use of gelatin in biomedical research

Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL porous scaffolds

Contact Info

Product

Resources

About