Comparative study of pathological response evaluation systems after neoadjuvant chemotherapy for breast cancer: developing predictive models of multimodal ultrasound features including shear wave elastography combined with puncture pathology

Ding, Ying; Song, Xuemei; Guan, Ling; Wang, Weili; Song, Bo; Kang, Yaqiong; Jia, Yingying; Zhu, Yongfa; Nie, Fang

doi:10.21037/qims-22-910

Cited by 3 publications

(4 citation statements)

References 44 publications

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“…In addition, several antecedent studies underscore the superiority of pretreatment SWE over ultrasound alone in predicting neoadjuvant chemotherapy response. Furthermore, an artificial intelligence model or nomogram developed by incorporating radiologic parameters from medical images including SWE and clinicopathologic data has exhibited excellent diagnostic predictive performance for the neoadjuvant chemotherapy response [32,33]. These results not only highlight the synergistic potential of various data sources but also emphasize the role of elasticity values as a pivotal factor in accurately predicting the response to neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 82%

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Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer

Kim,

Eun,

Ahn

et al. 2024

Cancers

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Shear-wave elastography (SWE) is an effective tool in discriminating malignant lesions of breast and axillary lymph node metastasis in patients with breast cancer. However, the association between the baseline elasticity value of breast cancer and the treatment response of neoadjuvant chemotherapy is yet to be elucidated. Baseline SWE measured mean stiffness (E-mean) and maximum stiffness (E-max) in 830 patients who underwent neoadjuvant chemotherapy and surgery from January 2012 to December 2022. Association of elasticity values with breast pCR (defined as ypTis/T0), pCR (defined as ypTis/T0, N0), and tumor-infiltrating lymphocytes (TILs) was analyzed. Of 830 patients, 356 (42.9%) achieved breast pCR, and 324 (39.0%) achieved pCR. The patients with low elasticity values had higher breast pCR and pCR rates than those with high elasticity values. A low E-mean (adjusted odds ratio (OR): 0.620; 95% confidence interval (CI): 0.437 to 0.878; p = 0.007) and low E-max (adjusted OR: 0.701; 95% CI: 0.494 to 0.996; p = 0.047) were independent predictive factors for breast pCR. Low elasticity values were significantly correlated with high TILs. Pretreatment elasticity values measured using SWE were significantly associated with treatment response and inversely correlated with TILs, particularly in HR+HER2- breast cancer and TNBC.

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Section: Discussionmentioning

confidence: 82%

“…The association between low elasticity values and a favorable response to neoadjuvant chemotherapy has been consistently represented [30][31][32][33][34][35]. In addition, several antecedent studies underscore the superiority of pretreatment SWE over ultrasound alone in predicting neoadjuvant chemotherapy response.…”

Section: Discussionmentioning

confidence: 99%

Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer

Kim,

Eun,

Ahn

et al. 2024

Cancers

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“…We set the expression of CASP1 as the dependent variable and incorporated the characteristics with P<0.05 as the independent variables into a multivariate analysis through binary logistic single-factor analysis. The results showed that tumor margin ( 25 , 26 ) and blood flow grade ( 21 ) were independent prognostic factors affecting the expression of CASP1 in BRCA (see Table 4 ).…”

Section: Resultsmentioning

confidence: 98%

“…Ultrasound, as a simple, non-radiation, non-invasive, real-time examination technology, is the first choice for screening and diagnosis of female BRCA. Conventional ultrasound, shear wave elastography, and contrast-enhanced ultrasound (CEUS), as commonly used methods for detecting breast lesions, have been widely accepted and recognized by patients and clinical doctors in the diagnosis of breast lesions and the evaluation of chemotherapy efficacy ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of caspase-1 (CASP1) combined with multimodal ultrasound features on the prognosis of breast cancer patients

Peng,

Wei,

Zhou

et al. 2023

Transl Cancer Res

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Background Breast cancer (BRCA) is the malignant tumor with the highest incidence rate among women in the world, and its mortality rate ranks second. The purpose of our study is to explore the correlation between caspase-1 ( CASP1 ) and the prognosis of BRCA patients and the potential mechanism of action, and to analyze the clinical value of CASP1 combined with multimodal ultrasound features in early screening and prognosis of BRCA. Methods We analyzed The Cancer Genome Atlas (TCGA) database to confirm that CASP1 was expressed in BRCA patients and determine whether its expression was correlated with patient prognosis. The relationship between CASP1 expression and survival was measured by the clinicopathological parameters. Multivariate analysis was performed using Cox regression, and a nomogram was developed using these results for quality assurance purposes. The correlations between CASP1 and immune cells were investigated using the Tumor Immune Estimation Resource (TIMER) and TCGA databases. Next, we performed gene set enrichment analysis (GSEA) to determine the potential mechanism of action. Finally, to analyze the effect of CASP1 combined with multimodal ultrasonography characteristics on the prognosis of BRCA patients was studied by analyzing the clinical data of patients. Results CASP1 expression was lower in BRCA tumor tissues than in the surrounding tissues. Patients with high CASP1 expression had better overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) than those with low CASP1 expression. GSEA suggested that CASP1 may affect the cell cycle, immune environment, inflammation, apoptosis, the HIPPOMERLIN pathway, Natural killer (NK) cell regulation of cytotoxicity, p53 expression, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, the mitogen-activated protein kinase (MAPK) pathway, extracellular matrix, etc., thereby influencing the biological events in BRCA. Among conventional ultrasound features and contrast-enhanced ultrasound (CEUS) features, mass margin status and blood flow grade were associated with the expression of CASP1 . Meanwhile, patients with poor ultrasound features tended to have low CASP1 expression. Conclusions CASP1 may be a novel predictive marker for BRCA patients. CASP1 combined with multimodal ultrasound features has good clinical value in the early screening and prognostic prediction of BRCA.

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Habitat-Based Radiomics for Revealing Tumor Heterogeneity and Predicting Residual Cancer Burden Classification in Breast Cancer

Li,

Wu,

Lin

et al. 2024

Preprint

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Comparative study of pathological response evaluation systems after neoadjuvant chemotherapy for breast cancer: developing predictive models of multimodal ultrasound features including shear wave elastography combined with puncture pathology

Cited by 3 publications

References 44 publications

Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer

Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer

Effect of caspase-1 (CASP1) combined with multimodal ultrasound features on the prognosis of breast cancer patients

Habitat-Based Radiomics for Revealing Tumor Heterogeneity and Predicting Residual Cancer Burden Classification in Breast Cancer

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