Comparative Study of Oral Antidiabetic Therapy and Insulin Therapy on Hepatic Steatosis in Patients With Type 2 Diabetes Mellitus

Hoza, Anica

doi:10.31925/farmacia.2018.4.14

Cited by 6 publications

(6 citation statements)

References 17 publications

(31 reference statements)

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“…Metabolic comorbidities or unhealthy lifestyle may result in poor glycaemic control and complications [11,21,22]. There is evidence that improving glycaemic control in patients improves immune function and prevents the appearance and progression of complications [10,18,21]. Recently, the use of SGLT2 inhibitors has produced concern about an increased risk of urinary tract infections in recipients of these medications because the levels of urinary glucose increased with greater doses of the medication.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility Among Diabetic Patients

Zaha¹

2020

FARMACIA

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The aim of this study was to characterize the prevalence of urinary tract infections (UTIs) in patients with diabetes mellitus, antimicrobial susceptibility pattern of the isolates and to explore the relationship with glycaemic balance. 1046 patients with diabetes, 84 with type 1 and 962 with type 2 diabetes were enrolled in the study. Each urine sample obtained by midstream collection was evaluated using dipstick and microscopical evaluation of the sediment, followed by uroculture. Most patients were diagnosed with type 2 diabetes, and the incidence of UTIs was 29.82%. The predominant isolates were E. coli and K. pneumoniae, followed by E. faecalis. The first two isolates were susceptible to cephalosporins, aminoglycosides, carbapenems, combinations with clavulanic acid or sulbactam, less to quinolones and resistant to ampicillin. Isolates strains of E. faecalis have shown a good sensitivity to antibiotics. No difference was noted between the samples with E. coli, K. pneumoniae and E. faecalis in terms of glycaemic balance. Rezumat Scopul acestui studiu a fost de a evalua prevalența infecțiilor tractului urinar la pacienți cu diabet zaharat, susceptibilitatea antimicrobiană a tulpinilor izolate și de a explora relația cu echilibrul glicemic. Au fost luați în studiu 1046 de pacienți cu diabet zaharat, 84 cu tip 1 și 962 cu tip 2. Fiecare probă de urină obținută prin recoltarea jetului mijlociu a fost evaluată biochimic precum și microscopia sedimentului, urmată de urocultură. Majoritatea pacienților au fost diagnosticați cu diabet zaharat de tip 2, iar prevalența infecției urinare a fost de 29,82%. Tulpinile izolate predominant au fost E. coli și K. pneumoniae, urmate de E. faecalis. Primele două au fost susceptibile la cefalosporine, aminoglicozide, carbapeneme, combinații cu acid clavulanic sau sulbactam, mai puțin la chinolone și rezistente la ampicilină. Tulpinile de E. faecalis au demonstrat o bună sensibilitate la antibiotice. Nu s-a observat nici o diferență între infecțiile urinare cu E. coli, K. pneumoniae și E. faecalis în ceea ce privește echilibrul glicemic evaluat prin valorile hemoglobinei glicozilate.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility Among Diabetic Patients

Zaha¹

2020

FARMACIA

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“…After a short period of follow-up, the main concern of physicians was directed to a possible increased risk of HCC induction by the DAAs treatments. Researchers warned recently about this high risk comparing to standard treatment cures, the hypothesis having major implications in HCV treatment management [7]. It looks that the rapid viral load decline and the rapid cessation of inflammatory liver process may lead to an altering of immune-surveillance activities and cancer occurrence by inefficient suppression of cancer promoters [3].…”

Section: Resultsmentioning

confidence: 99%

Interferon-Free Therapy Is Not a Trigger for Hepatocellular Carcinoma in Patients With Chronic Infection With Hepatitis C Virus

Suceveanu¹

2018

FARMACIA

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The literature focused on data regarding the occurrence of hepatocellular carcinoma (HCC) after interferon (IFN)-free therapy is ambiguous. Researchers are preoccupied to find if the risk of developing liver cancer is related only to the therapy per se or it is influenced by a multitude of factors. We aimed to develop a local analysis of risk factors associated with HCC occurrence in patients with liver cirrhosis due to HCV (hepatitis C virus) infection treated with IFN-free therapy. We made an observational, retrospective study, between 2016 -2019, on 188 cirrhotic patients with HCV infection, diagnosed, treated and followed-up by screening for HCC occurrence, using the recordings from the patient's charts available in the archive of the Gastroenterology Lab, "Aquamed" Clinic, Constanța County, Romania. We noted the demographic, lab, imagistic data and treatment procedures applied, comparing two groups of patients: the IFN-free therapy group -89 patients and the standard IFN therapy group -99 patients. As statistic method, we used the SAS Cox proportional hazards regression procedure, in order to calculate the HR (hazard ratio) and CI (confidence interval) 95% for each parameter studied as risk factor involved in HCC occurrence. In the unadjusted model, there was estimated an increased risk in HCC occurrence in IFN-free therapy group compared to standard IFN therapy group (p = 0.0341). After adjustment for age, gender, severity of the disease, (Child-Pugh classification) or complications, there was not a statistically significant difference between IFN-free therapy group or IFN therapy group in order to develop HCC (hazard ratio = 0.05, p = 0.5038). Our observational study, even if made on a small number of patients, confirms that IFN-free therapy is safe, the benefits obtained covering the risks. Our study results did not find a link between IFN-free therapy and HCC occurrence over the known risk of liver cirrhosis, when taking into account multiple features of disease prior to treatment onset. RezumatLiteratura axată pe datele referitoare la apariția carcinomului hepatocelular după terapia fără interferon (IFN) este ambiguă în acest moment. Cercetătorii sunt preocupați să stabilească dacă riscul de a dezvolta hepatocarcinom este legat numai de terapia per se sau este influențat de o multitudine de factori. În acest context, ne-am propus să facem o analiză locală a factorilor de risc asociați cu apariția HCC la pacienții cu ciroză hepatică datorată infecției cu virus hepatitic C (VHC) tratată fără IFN. Am efectuat un studiu observațional, retrospectiv, între anii 2016 -2018 pe 188 de pacienți cu infecție cu VHC diagnosticați, tratați și urmăriți prin screening pentru apariția HCC, folosind înregistrările din diagramele pacientului, disponibile în arhiva Laboratorului de Gastroenterologie, Clinica "Aquamed", județul Constanța, România. Am analizat datele demografice, de laborator și imagistice, precum și procedurile de tratament aplicate, comparând două grupuri de pacienți: grupul de terapie fără IFN -89 pacienț...

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“…The risks associated with MS of cardiovascular disease, type 2 diabetes, as well as the development of bacterial resistance in infections increase the risk of mortality [ 14 ]. Numerous studies follow the evolution of patients with MS, due to the increasing trend of cases, in terms of associated diseases [ 15 ], abdominal obesity [ 16 ], or the correlation of nutritional status with hepatic steatosis [ 17 ]. Some plants promote obesity, resulting from the study published in 2019, but do not influence the development of insulin resistance, when administered for 6 weeks, in rats [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome

et al. 2021

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(1) The metabolic syndrome (MS) promotes acute and chronic infections, due to the pro-inflammatory condition given by TNFα and IL6 or by affecting the microbiota. MS is also correlated with insulin resistance, causing inflammation and infections throughout the organism. (2) The purpose of this study was to track the effect of using the essential oil of Origanum vulgare L. (EOO) as an antibacterial treatment, compared to allopathic treatment with antibiotics in MS patients. A group of 106 people with MS was divided into four subgroups: L1—staphylococcal infection group, L2—Escherichia coli infection group, L3—streptococcal infection group with EOO treatment, and CG—control group without infection or treatment. (3) EOO is responsible for the antibacterial effect, and reduced minor uncomplicated infections. After a 10-day treatment, intestinal side effects were absent, improving the phase angle. (4) The results suggest that EOO may exhibit an antibacterial effect, similar to the antibiotic treatment, without promoting MS-specific dysbiosis, and it also improves the phase angle in patients, which is used as an index of health and cellular function.

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Comparative Study of Oral Antidiabetic Therapy and Insulin Therapy on Hepatic Steatosis in Patients With Type 2 Diabetes Mellitus

Cited by 6 publications

References 17 publications

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility Among Diabetic Patients

Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility Among Diabetic Patients

Interferon-Free Therapy Is Not a Trigger for Hepatocellular Carcinoma in Patients With Chronic Infection With Hepatitis C Virus

The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome

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