Comparative study of non-destructive methods to quantify thickness of tablet coatings

Cahyadi, Christine; Karande, A.D.; Chan, Lai Wah; Heng, Paul Wan Sia

doi:10.1016/j.ijpharm.2010.07.020

Cited by 41 publications

(10 citation statements)

References 12 publications

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“…A number of methods have been evaluated as a means of coating quality assessment and monitoring. These methods range from coating weight gain to various destructive and non-destructive techniques [2,3]. Routinely in the pharmaceutical industry, tablet coating is controlled by employing calculations on tablet weight gain during the coating processes with respect to the amount of coating solution applied.…”

Section: Introductionmentioning

confidence: 99%

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Zhong¹,

Shen

et al. 2011

Optics and Lasers in Engineering

124

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Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10–140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 10–60 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.5–1.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40–140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings

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Section: Introductionmentioning

confidence: 99%

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Zhong¹,

Shen

et al. 2011

Optics and Lasers in Engineering

124

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show abstract

“…Raman spectroscopy has been shown to be suitable to differentiate between tablets coated under different conditions by Cahyadi et al [96] and our results give a good indication of the same ability in pellets, however for a definitive conclusion further experiments would be needed.…”

Section: Raman Spectroscopysupporting

confidence: 53%

Manufacturing and investigation of coated pellets containing water-soluble active ingredients

Nikowitz¹

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“…X-ray diffraction is currently only used in the laboratory settings. [36,37] 3. CONCLUSION The prevention of counterfeiting is largely based on deterrence, and a high likelihood of detection increases the risks for the criminals who are producing fake drugs.…”

Section: Limitationsmentioning

confidence: 99%

Non-Destructive Analytical Techniques for Detection of Counterfeit Pharmaceutical Preparations

.¹,

.²,

.³

et al. 2018

JCPR

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Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. Currently, counterfeit medicine is a significant issue for the pharmaceutical world, and it targets all types of therapeutic areas. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated on spot even. For this analytical instrumentation and methods play an important role. Many of the methods require varying degrees of irreversible sample preparation (removal from sealed container or blister pack, crushing into powder, dissolution with solvent, etc.) and therefore cannot be used in nondestructive mode. Now, direct methods to detect counterfeit products and to analyze the properties of the product itself are available. This can either be achieved using laboratory-based testing of purchased or seized samples, or can increasingly be done using portable, non-invasive techniques. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs.

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Comparative study of non-destructive methods to quantify thickness of tablet coatings

Cited by 41 publications

References 12 publications

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Manufacturing and investigation of coated pellets containing water-soluble active ingredients

Non-Destructive Analytical Techniques for Detection of Counterfeit Pharmaceutical Preparations

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