Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia

Salem, Ayad Mohammed; Yar, Talay; Bamosa, Abdullah O; Al-Quorain, Abdulaziz; Yasawy, Mohamed I.; Alsulaiman, Raed; Randhawa, Muhammad Akram

doi:10.4103/1319-3767.65201

Cited by 100 publications

(45 citation statements)

References 39 publications

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“…The patients were randomly included into the following groups: 1) triple therapy; 2) 1 g N. sativa plus 40 mg omeprazole; 3) 2 g N. sativa plus 40 mg omeprazole; 4) 3 g N. sativa plus 40 mg omeprazole, for 4 weeks, respectively. Remarkably, the combination of 2 g N. sativa plus 40 mg omeprazole was shown to be most effective in eradicating H. pylori [28]. Future clinical research should further expand these promising findings to diseases caused by other microbial pathogens.…”

Section: Discussionmentioning

confidence: 99%

Finding novel antibiotic substances from medicinal plants — Antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria

Bakal

Bereswill

Heimesaat

2017

EuJMI

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The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. The medicinal herb Nigella sativa and its derivatives constitute promising candidates. In a comprehensive literature survey (using the PubMed data base), we searched for publications on the antimicrobial effects of N. sativa particularly directed against MDR bacterial strains. In vitro studies published between 2000 and 2015 revealed that N. sativa exerted potent antibacterial effects against both Gram-positive and Gram-negative species including resistant strains. For instance, N. sativa inhibited the growth of bacteria causing significant gastrointestinal morbidity such as Salmonella, Helicobacter pylori, and Escherichia coli. However, Listeria monocytogenes and Pseudomonas aeruginosa displayed resistance against black cumin seed extracts. In conclusion, our literature survey revealed potent antimicrobial properties of N. sativa against MDR strains in vitro that should be further investigated in order to develop novel therapeutic perspectives for combating infectious diseases particularly caused by MDR strains.

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Section: Discussionmentioning

confidence: 99%

Finding novel antibiotic substances from medicinal plants — Antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria

Bakal

Bereswill

Heimesaat

2017

EuJMI

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“…Administration of 5 g of vitamin C for 4 weeks in H. pylori positive patients with chronic gastritis resulted in recovery of 30% of the patients treated with vitamin C [52]. Treatment effects with 1 g, 2 g, and 3 g Nigella sativa administered with omeprazole were 47.6%, 66.7%, and 47.8% [53], respectively, while as a stand alone supplement GutGard showed 56% cure rate. Results of earlier clinical studies provide insights on the eradication rates of mono-, dual, and triple therapies.…”

Section: Discussionmentioning

confidence: 99%

Effect of GutGard in the Management ofHelicobacter pylori: A Randomized Double Blind Placebo Controlled Study

Puram

Suh²,

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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A randomized, double blind placebo controlled study was conducted to evaluate the efficacy of GutGard (root extract of Glycyrrhiza glabra) in the management of Helicobacter pylori (H. pylori) gastric load. Participants diagnosed with H. pylori infection were randomly assigned to two groups to orally receive 150 mg of GutGard (n = 55) or placebo (n = 52) once daily for 60 days. H. pylori infection was assessed using 13C-urea breath test (13C-UBT) at days 0, 30, and 60. Stool Antigen test (HpSA) was also performed on days 0, 30, and 60. Repeated measures of analysis of variance (RMANOVA), chi-square, and Fisher's exact probability tests were used to compare the treatment outcomes. A significant interaction effect between group and time (P = 0.00) and significant difference in mean Delta Over Baseline (DOB) values between GutGard (n = 50) and placebo (n = 50) treated groups after intervention period were observed. On day 60, the results of HpSA test were negative in 28 subjects (56%) in GutGard treated group whereas in placebo treated group only 2 subjects (4%) showed negative response; the difference between the groups was statistically significant. On day 60, the results of 13C-UBT were negative in 24 (48%) in GutGard treated group and the difference between the groups was statistically significant. The findings suggest GutGard is effective in the management of H. pylori.

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“…[7] Furthermore, the 3 g dose of NS was less potent than the 2 g in eradicating Helicobacter pylori in nonulcer dyspeptic patients. [26]…”

Section: Discussionmentioning

confidence: 99%

Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients

Kaatabi

Bamosa

Lebda

et al. 2012

J Fam Community Med

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Background and Aim:The atherogenic pattern of dyslipidemia associated with type 2 diabetes mellitus (DM) has been increasingly discussed. We have recently reported a hypoglycemic effect of Nigella sativa (NS) seeds in patients with type 2 DM. In this study we sought to assess the impact of NS seeds on lipid profile in type 2 diabetic patients.Patients and Method:A total of 94 patients with type 2 DM were recruited and divided into 3 dose groups. Capsules containing NS were administered orally in a dose of 1, 2, and 3 g/day for 12 weeks. All patients were subjected to measurement of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) before treatment and 4, 8, and 12 weeks thereafter.Results:Patients receiving 1 g/day NS seeds for 12 weeks (group 1) showed nonsignificant changes in all the parameters except for a significant increase in HDL-c after 4 weeks of treatment. However, patients ingested 2 g/day NS displayed a significant decline in TC, TG, and LDL-c, and a significant elevation in HDL-c/LDL-c, compared with their baseline data and to group 1 patients. Increasing NS dose to 3 g/day failed to show any increase in the hypolipdemic effect produced by the 2 g/day dose.Conclusion:NS supplementation at a dose of 2 g/day for 12 weeks may improve the dyslipidemia associated with type 2 diabetic patients. Therefore, NS is a potential protective natural agent against atherosclerosis and cardiovascular complications in these patients.

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Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia

Cited by 100 publications

References 39 publications

Finding novel antibiotic substances from medicinal plants — Antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria

Finding novel antibiotic substances from medicinal plants — Antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria

Effect of GutGard in the Management ofHelicobacter pylori: A Randomized Double Blind Placebo Controlled Study

Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients

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