Comparative Study of Mifepristone with Dinoprostone Gel in Induction of Labor in Full-term Pregnancy: An Open-label Randomized Controlled Trial

Abstract

Aim and objective: This study aims to compare the effectiveness and safety of mifepristone with PGE2 gel for cervical ripening and induction of labor. Materials and methods:This was an open-label randomized controlled study; 191 patients were included and divided into 94 patients in group A (mifepristone) and 97 patients in group B (PGE2 gel). Tablet mifepristone 200 mg orally was given in group A, and intracervical PGE2 gel was given in group B. Preinduction Bishops score was noted at beginning to compare the improvement in Bishops score after induction. Mode of delivery and induction to delivery interval, complication, and neonatal outcome were noted in both groups. Results: Change in Bishops score was noted after 24 hour, and it was comparable in both groups. Induction to delivery interval was significantly less in group B (29 hours) as compared to group A (34 hours). The rate of vaginal delivery was 62.5% in group A and 55.4% in group B. In group A 10.2% and 16.3% in group B required NNU admission. Conclusion:Mifepristone is more effective than PGE2 gel for cervical ripening as it has high rate of vaginal delivery and good neonatal outcome.

Comparison of outpatient with inpatient mifepristone usage for cervical ripening: A randomised controlled trial

“…We found that women who underwent outpatient cervical ripening with mifepristone had the same rate of Bishop score improvement as women in the inpatient group at 24 h (1 (1–2) vs. 1 (1–2), P = 0.416) and 48 h (3 (2–4) vs. 3 (1–4), P = 0.527). This Bishop score improvement was the same as or slightly lower than that reported in other studies [25] , [26] , [27] , [30] , [31] , [32] , [33] , [34] , [35] , [36] .…”

“…An additional advantage of the high degree of cervical ripening was the low rate of oxytocin use for labour induction (6.25 % and 12.96 %, respectively). We assume that this is the lowest rate among the available data (25–90 % in other studies) [19] , [24] , [30] , [31] , [33] , [36] .…”

Comparative study of induction of labour with oral mifepristone and intracervical dinoprostone in primigravida

“…It is the 19 norsteroid, which has greater affinity for progesterone receptor than progesterone itself. It blocks the action of progesterone at the cellular level [4] .…”