Comparative Study of Macular Ganglion Cell–Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Measurement: Structure–Function Analysis

Shin, Hoon−Kyu; Park, Hae-Young Lopilly; Jung, Kyoung In; Park, Chan Kee

doi:10.1167/iovs.13-12667

Cited by 59 publications

(61 citation statements)

References 37 publications

(48 reference statements)

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“…These results are similar to earlier studies 7 12. We also demonstrated that each mGCIPLT at three different parafoveal locations was significantly correlated with matched regional VF regardless of MS scale or hemimacular location (R=0.406–0.801, p<0.001, table 3), indicating that mGCIPLT measurements are closely associated with central VF sensitivity in glaucoma.…”

Section: Discussionsupporting

confidence: 91%

“…In the HFA 10-2 and 24-2 VF programme, the global central VF mean sensitivity (MS) was derived from the average of 68 and 12 central 10° VF points, excluding two blind spot points, which corresponded topographically to the retina within 4.8 mm of the fovea and the area of macular ganglion cell-inner plexiform layer thickness (mGCIPLT) measurement annulus 7. This global MS value was then correlated with the average mGCIPLT.…”

Section: Methodsmentioning

confidence: 99%

“…As linear regression models can well describe the relationship between VF sensitivity expressed in dB and 1/L scale and mGCIPLT or RNFL thickness (RNFLT),7 9 relationships between various macular structural parameters and the corresponding MS in the current study were evaluated with linear regression analyses using both MS scales.…”

Section: Methodsmentioning

confidence: 99%

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Macular structure–function relationship at various spatial locations in glaucoma

et al. 2015

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Background/aimsTo study whether the structure–function (S-F) relationship in glaucoma differs according to macular location using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry 10-2 and 24-2 visual fields (VFs).MethodsWe enrolled 151 eyes of 151 healthy, preperimetric and perimetric glaucomatous subjects. Macular ganglion cell-inner plexiform layer thicknesses at different parafoveal locations were measured using Cirrus SD-OCT. The mean sensitivity of 10–2 and 24–2 VFs was recorded in the decibel and 1/L scales. The topographic relationships between structure and function were assessed at different parafoveal and hemimacular locations using ‘weighted’ correlation coefficients. The strength of S-F relationships between macular ganglion cell-inner plexiform layer thickness measurements and VF mean sensitivity in various parafoveal locations and in superior and inferior hemimacula was compared using Steiger's test.ResultsThe temporal parafoveal sector showed a significantly greater S-F relationship in each hemimacula compared with other parafoveal sectors (p<0.05). The inferior hemimacula showed a significantly greater S-F relationship than superior hemimacula (p<0.001).ConclusionsThe strength of the S-F associations at the temporal parafoveal location is significantly greater than that of the central or nasal parafoveal location in each hemimacula. The strength of the S-F association is significantly greater in the inferior hemimacula than in the superior hemimacula.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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Macular structure–function relationship at various spatial locations in glaucoma

et al. 2015

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“…The GCIPL and GCC thicknesses also were reported to be correlated with the global or corresponding regional SAP sensitivity (in dB or the linear scale) in groups with only glaucomatous eyes or groups with glaucomatous and normal eyes. [6][7][8][9]11 Although correlation between cpRNFL, GCC, or GCIPL thickness and retinal sensitivity was the subject of many previous studies, to the best of our knowledge, the current study is the first to report a significant difference in the relationship between the GCC (GCIPL) thickness and SAP linear scale sensitivity in corresponding macular regions between eyes with mild and advanced central VF. That is, (DGCCT 4 test points [DGCIPLT 4 test points ]/D LSAP 4 test points ) was approximately 2.7 (2.2) times greater, or given a same reduction in the retinal sensitivity, reduction in RGC-related inner retinal layer thickness will be approximately 2.5 times greater, in the macular area with advanced glaucomatous damage than in that with mild glaucomatous damage.…”

Section: Discussionmentioning

confidence: 67%

“…Ganglion cell displacement was estimated with the following formula: y ¼ 1.29 3 (x þ 0.46) 0.67 , where y indicates ganglion cell eccentricity and x indicates cone eccentricity. 28 The dB values for the SAP sensitivity in the four central test points of the HFA 24-2 test program were antilogged to obtain the sensitivity in the linear scale (1/Lambert ¼ 10 0.13dB value ), [2][3][4]6,8,11,29 of which the mean of the four central test points was calculated using the above four anti-logged dB values (LSAP 4 test points ). Age, [20][21][22][23]24,25 axial length or refraction, 21,23,25 and disc size 20 are external factors that reportedly can affect the OCT-measured thicknesses of the cpRNFL, GCC, or GCIPL.…”

Section: Optical Coherence Tomography Measurementmentioning

confidence: 99%

Differences in Relationship Between Macular Inner Retinal Layer Thickness and Retinal Sensitivity in Eyes With Early and Progressed Glaucoma

Araie

Murata

Iwase

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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METHODS. One eye of 153 POAG patients was included. Using spectral-domain optical coherence tomography, we measured the average thickness of the macular ganglion cellinner plexiform layers (GCIPLT) and the macular nerve fiber layer/GCIPL (ganglion cell complex [GCCT]) in a 0.9-mm-diameter ganglion cell displacement-adjusted circular area corresponding to the four central test points of the Humphrey Perimeter 24-2 program and correlated the results with the average retinal sensitivity (1/Lambert) at the corresponding test points, with adjustment for other confounding factors.RESULTS. Ninety-three eyes had mild central and 60 eyes advanced central VF damage with an average total deviation (TD) of the four test points of greater than or equal to À4 decibels (dB) (mild group) and less than À4 dB (more severe group), respectively; the average mean deviations were À3.0 and À9.8 dB, respectively. In the mild group, the GCCT and GCIPLT were correlated significantly and positively with the average retinal sensitivity with partial regression coefficient of 0.007 and 0.005, respectively, and in the more severe group with partial regression coefficient of 0.019 ¼ 0.007 þ 0.012 (P ¼ 0.007) and 0.010 ¼ 0.005 þ 0.005 (P ¼ 0.078), respectively. The axial length and disc size were correlated with GCIPLT with marginal significance (P ¼ 0.052 and P ¼ 0.042). CONCLUSIONS.The relationship between the macular GCC and GCIPL thickness and retinal sensitivity at the corresponding retinal areas differed between POAG with mild and advanced central VF damage.Keywords: ganglion cell complex, macula, retinal sensitivity G laucoma damages the retinal ganglion cell (RGC) bodies and axons and is associated with characteristic patterns of visual field (VF) defects and changes in the appearance of the optic nerve head (ONH). Thinning of the RGC-related retinal layers caused by RGC loss is associated with decreased VF sensitivity. Structural and functional tests are indispensable for assessing the extent of glaucomatous damage, especially in early glaucoma. 1A number of studies have used optical coherence tomography (OCT) to study correlations between standard automated perimetry (SAP)-determined sensitivity and OCT-determined thicknesses of the RGC-related retinal layers such as the circumpapillary retinal nerve fiber layer (cpRNFL); combined macular RNFL (mRNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL), macular ganglion cell complex (GCC); and the combined macular GCL and IPL (GCIPL).2-14 Previous studies have agreed that the correlation between the OCTmeasured thicknesses of the RGC-related retinal layers and corresponding SAP sensitivities is weak and insignificant when the SAP sensitivities are normal. [2][3][4][5][6][7][8][9][10][11][12][13] This finding has been explained by the fact that substantial RGC loss (i.e., at least 10% to approximately 20%) resulting from glaucomatous damage is needed to lower the measured SAP sensitivity to outside the normal range, 2,3,15 and it is reasonable to assume that the SAP sensitivitie...

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Retrochiasmal Disorders

Vuong

Hedges

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Comparative Study of Macular Ganglion Cell–Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Measurement: Structure–Function Analysis

Cited by 59 publications

References 37 publications

Macular structure–function relationship at various spatial locations in glaucoma

Macular structure–function relationship at various spatial locations in glaucoma

Differences in Relationship Between Macular Inner Retinal Layer Thickness and Retinal Sensitivity in Eyes With Early and Progressed Glaucoma

Retrochiasmal Disorders

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