Comparative Study of Lipid and Fatty Acid Profile in Liver Tissues of Male and Female Silurus triostegus During the Catching Seasons

Kaçar, Semra; Başhan, Mehmet

doi:10.26650/ase2021863164

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…However, corrective factors for PCgonads and PCliver were calibrated to account for variations in lipid content between male and female fish. This variation in lipids was attributed to factors such as VTG synthesis and accumulation (Johnston et al, 2016;Kacar and Bashan, 2021). In particular, male ZF exhibited roughly double the average lipid content in their liver and gonads compared to females, as reported by Pery et al…”

Section: Model Calibrationsupporting

confidence: 63%

Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

LY,

De Oliveira,

Chadili

et al. 2023

Preprint

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Azole fungicides are highly suspected endocrine disruptors (ED) and are frequently detected in surface water. Among them, there are prochloraz (PCZ), a reference molecule and imazalil (IMZ), a highly suspected ED. Little is known about their toxicokinetic (TK) behavior in fish. Hence, research suggested that an improved risk assessment could be achieved by gaining insight into their TK behavior. The aim of this study is to understand and model the TK of both substances in different fish species. Two experiences on zebrafish exposed to IMZ and PCZ were performed to address the lack of in vivo TK data. A physiologically based kinetic (PBK) model applied to IMZ and PCZ was developed, capable to model different exposure scenario. The parameters of the PBK model were simultaneously calibrated on datasets reporting internal concentration in several organs in three fish species (original and literature datasets) by Bayesian methods (Monte Carlo Markov Chain). Model predictions were then compared to other experimental data (i.e. excluded from the calibration step) to assess the predictive performance of the model. The results strongly suggest that PCZ and IMZ are actively transported across the gills, resulting in a small fraction being effectively absorbed by the fish. The model’s results also confirms that both molecules are extensively metabolized by the liver into mainly glucuronate conjugates. Overall, the model performances were satisfying, predicting internal concentrations in several key organs. On average, 90% of experimental data were predicted within a two-fold range. The PBK model allows the understanding of IMZ and PCZ kinetics profiles by accurately predicting internal concentrations in three different fish species regardless of the exposure scenario. This enables a proper understanding of the mechanism of action of EDs at the molecular initiating event (MIE) by predicting bioaccumulation in target organs, thus linking this MIE to a possible adverse outcome.

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Section: Model Calibrationsupporting

confidence: 63%

Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

LY,

De Oliveira,

Chadili

et al. 2023

Preprint

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show abstract

“…Further, in mature Black Sea trout (Salmo trutta labrax), 16:0 was the most representative FA of the class not only in the liver but also in other tissues [29]. The 18:0 SFA was the second most quantified SFA in the liver of brown trout, as reported in other fish studies [10,14,16]. Also, as observed here, several studies recognize 18:1 n-9 as the predominant MUFA in different tissues of trout species [10,29,30].…”

Section: Fa Profiles In Cultured Brown Troutmentioning

confidence: 81%

“…Interestingly, in macrostigma trout, the fatty acid contents in the liver expressed differences between males and females that were more striking than in the muscle [10]. Up until now, seasonal changes in liver fatty acid contents have been found, for example, in the European chub (Squalius cephalus) [14], pikeperch (Sander lucioperca) [15], catfish (Silurus triostegus) [16], and rainbow trout [13]. Female rainbow trout liver evidenced a high accumulation of 22:6n-3 (docosahexaenoic acid, DHA) during vitellogenesis [7], which has been identified as a crucial fatty acid for egg quality and larvae viability in fish [17].…”

Section: Introductionmentioning

confidence: 99%

Liver and Plasma Fatty Acid Characterization in Cultured Brown Trout at Distinct Reproductive Stages

Madureira,

Santos,

Simões

et al. 2023

Biology

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Fatty acids are energy sources, and their profiles are used as biomarkers of metabolic status and physiological changes in fish. Within this context, the main aim of this study was to identify the fatty acids that best discriminate the reproductive status of male and female farmed brown trout. The fatty acid composition in liver and plasma samples from the adults of both sexes was monitored along four distinct reproductive stages, namely the spawning capable (December), regressing (March), regenerating (July), and developing (November) stages. Irrespective of the sex and stage, the most representative fatty acids were palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1 n-9), arachidonic acid (20:4 n-6), eicosapentaenoic acid (EPA, 20:5 n-3), and docosahexaenoic acid (DHA, 22:6 n-3). There were no significant sex differences in fatty acid classes in the liver and plasma. Despite this, there were several changes in individual fatty acid levels between the sexes. In the liver, both males and females showed high monounsaturated fatty acid and low polyunsaturated fatty acid (PUFA) levels during the regressing and regenerating stages. At spawning capable and developing stages, a reverse profile was noted. The plasma profiles were mainly influenced by changes in saturated fatty acids and PUFAs in males and by PUFA in females. Based on the most representative fatty acids, four patterns were established for female plasma samples, one for each reproductive stage. This scenario suggests that female plasma samples are promising for the discrimination of gonadal reproductive status, and this potential can be further explored in aquaculture and environmental monitoring studies.

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Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

Ly,

De Oliveira,

Chadili

et al. 2024

Environ Sci Pollut Res

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Comparative Study of Lipid and Fatty Acid Profile in Liver Tissues of Male and Female Silurus triostegus During the Catching Seasons

Abstract: comparative study of lipid and fatty acid profile in liver tissues of male and female Silurus triostegus during the catching seasons. Aquatic Sciences and Engineering, 36(4),[166][167][168][169][170][171][172][173][174]

Cited by 4 publications

References 37 publications

Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

Liver and Plasma Fatty Acid Characterization in Cultured Brown Trout at Distinct Reproductive Stages

Imazalil and prochloraz toxicokinetics in fish probed by a physiologically based kinetic (PBK) model

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