Comparative study of Lederle/Takeda acellular and Lederle whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants in Germany

Heininger, Ulrich; Cherry, James D.; Christenson, Peter D.; Eckhardt, Thomas; Goering, Uwe; Jakob, Peter; Kasper, Wolfgang; Schweingel, Dieter; Laussucq, Suzanne; Hackell, Jill G.; Mezzatesta, Joseph R.; Scott, Jane V.; Stehr, K.

doi:10.1016/0264-410x(94)90014-0

Cited by 61 publications

(26 citation statements)

References 15 publications

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“…Vaccinees who received FHA containing pertussis vaccines mounted a substantial antibody response to this protein (217,218,332). In general, acellular vaccines which contain FHA as well as PT toxoid have slightly greater efficacy than monocomponent PT toxoids (3,131,149,734,735,737).…”

Section: Virulence Determinantsmentioning

confidence: 99%

“…In general, acellular vaccines which contain FHA as well as PT toxoid have slightly greater efficacy than monocomponent PT toxoids (3,131,149,734,735,737). However, one whole-cell component DTP vaccine in which vaccinees did not mount an antibody response to FHA was nevertheless highly efficacious (218,332,334,719). Most importantly, in two studies in which serologic correlates of immunity were determined, it was found that FHA made no contribution to protection (148,736).…”

Section: Virulence Determinantsmentioning

confidence: 99%

“…For example, the former Lederle DTP vaccine (Tri-Immunol) contained a minimal amount of FHA and generated a minimal anti-FHA response, but it was more efficacious than the Lederle-Takeda DTaP vaccine (ACEL-IMMUNE), which contained a large amount of FHA and generated a vigorous antibody response to FHA (332,334,719). The most definitive data relating to the importance of PT, FHA, PRN, and FIM are presented in two studies of serologic correlates of immunity (148,736).…”

Section: Pathogenesis and Immunitymentioning

confidence: 99%

“…Using ELISA, the qualitative and quantitative differences between class-specific antibodies (IgA, IgE, IgG, and IgM) can be determined. In general, IgG and IgM antibodies, but not IgA antibodies, develop against vaccine antigens following primary immunization (146,332,579,757,821). Interestingly, persons who have been primed by infection respond to immunization with not just an IgG response but also an IgA response (446).…”

Section: Pathogenesis and Immunitymentioning

confidence: 99%

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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Virulence Determinantsmentioning

confidence: 99%

Section: Virulence Determinantsmentioning

confidence: 99%

Section: Pathogenesis and Immunitymentioning

confidence: 99%

Section: Pathogenesis and Immunitymentioning

confidence: 99%

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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…Bordetella pertussis and B. parapertussis are human pathogens, causing whooping cough or pertussis, and are endemic in both vaccinated and unvaccinated populations worldwide (11,12,20,30). B. bronchiseptica is a very common cause of respiratory tract infections in many animals, causing atrophic rhinitis in pigs, snuffles in rabbits, and kennel cough in dogs, but rarely infects humans (7,29).…”

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confidence: 99%

Role ofBordetellaO Antigen in Respiratory Tract Infection

et al. 2003

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Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive immunity. The membrane-distal repeated carbohydrate structure of LPS, the O antigen, can prevent antibody functions and may vary as a mechanism of immune evasion. Genes of the wbm locus are required for the assembly of O antigen on the animal pathogen Bordetella bronchiseptica and the human pathogen B. parapertussis. However, the important human pathogen B. pertussis lacks these genes and a number of in vitro and in vivo characteristics associated with O antigen in other organisms. To determine the specific functions of O antigen in these closely related Bordetella subspecies, we compared wbm deletion (⌬wbm) mutants of B. bronchiseptica and B. parapertussis in a variety of assays relevant to natural respiratory tract infection. Complement was not activated or depleted by wild-type bordetellae expressing O antigen, but both ⌬wbm mutants activated complement and were highly sensitive to complement-mediated killing in vitro. Although the O-antigen structures appear to be substantially similar, the two mutants differed strikingly in their defects within the respiratory tract. The B. parapertussis ⌬wbm mutant was severely defective in colonization of the tracheas and lungs of mice, while the B. bronchiseptica ⌬wbm mutant showed almost no defect. While in vitro characteristics such as serum resistance may be attributable to O antigen directly, the role of O antigen during infection appears to be more complex, possibly involving factors differing among the closely related bordetellae or different interactions between each one and its host.

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Acellular vaccines for preventing whooping cough in children

Tinnion¹,

Hanlon²

2006

Cochrane Database of Systematic Reviews

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Comparative study of Lederle/Takeda acellular and Lederle whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants in Germany

Cited by 61 publications

References 15 publications

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Role ofBordetellaO Antigen in Respiratory Tract Infection

Acellular vaccines for preventing whooping cough in children

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