Comparative study of laser and lamp fluorescence of cancer and normal tissue through wavelet transform and singular value decomposition

Abstract

A systematic investigation of the fluorescence characteristics of normal and cancerous human breast tissues is carried out, using laser and lamp as excitation sources. It is found that earlier observed subtle differences between these two tissue types in the wavelet domain are absent, when lamp is used as excitation source. However, singular value decomposition of the average spectral profile in the wavelet domain yields strong correlation for the cancer tissues in the 580-750 nm regimes indicating weak fluorophore activity in this wavelength range.