Comparative study of ion-exchange resin Indion 204 and Indion 214 for the taste masking of metoclopramide hydrochloride and formulation of rapid-disintegrating tablets

Dahima, Rashmi; Sharma, Rajesh

doi:10.4103/0973-8398.68461

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…It was found that upon increasing the processing temperature the entrapment efficiency was significantly (P< 0.05) increased due to increase in the solubility of the drug, the higher temperature tends to increase the diffusion rate of ions by decreasing the thickness of exhaustive exchange zone, as well as increased temperature during complexation increases ionization of drug and resin. [27] , as shown in…”

Section: Effect Of Temperaturementioning

confidence: 77%

Variables affecting sulfasalazine - ion exchange resin complexation

Wohaib,

Maraie

2019

AJPS

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The aim of this work is studying the effect of different variables on the loading of sulfasalazine on DEAE sephadex A 25 ion exchange resin as a carrier for systemic action. Different drug: resin complexes (resinate) of different ratios (2:1, 1:1, 1:2, 1:4, 1:6) were prepared, dionized distilled water used to prepare sulfasalazine solution, and their entrapment efficiency was estimated through changing variable conditions including temperature of stirring, stirring time, stirring speed, pH. The best complex was formed using 1:6 drug: resin ratio prepared at 50 ºC, stirring speed 400 rpm for 120 minutes in deionized water (pH 7). The prepared complex gave 77.8% drug release within 15 minute and continued up to 97.613% within 75 minute upon exchanging the drug with ions of similar charge in the dissolution medium (phosphate buffer pH 7.4).

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Section: Effect Of Temperaturementioning

confidence: 77%

Variables affecting sulfasalazine - ion exchange resin complexation

Wohaib,

Maraie

2019

AJPS

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“…Differential scanning calorimetry (DSC) was carried out for the characterization of the complex formed. All the DRCs were subjected to DSC and the thermograms were studied for drug-polymer complex formation [13][14][15].…”

Section: Evaluation Of the Prepared Drug-resin Complexes For Drug Relmentioning

confidence: 99%

Design, Optimization, and Statistical Evaluation of Oral Reconstituted Suspension of Clarithromycin Using Ion-Exchange Resins

Komal

Harikrishnan

2020

Asian J Pharm Clin Res

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Objectives: The objective of the present study is taste masking of bitter clarithromycin using Indion 204, Indion 234, and Tulsion 335 as ion-exchange resins, which forms insoluble complexes, inhibiting the drug release in saliva as ion-exchange resins are cross-linked polymers, water-insoluble that contains salt-forming groups in repeating positions on the polymer chain. Drugs that are bitter and cationic get adsorbed onto weak cationic exchange resins of carboxylic acid functionality such as Indion 204, Indion 234, and Tulsion 335 to form non-bitter complexes. Methods: The drug-resin complex loading process was optimized for the resin content, activation, swelling time, stirring time, influence of pH, and temperature for maximum drug loading and the formed complex was evaluated by differential scanning calorimetry (DSC) to confirm complex formation. The drug-resin complex was also characterized by their micromeritic and rheological properties. These complexes were used to prepare oral reconstituted suspensions and the taste was evaluated. The formulation was evaluated for various parameters such as sedimentation volume, pH, redispersibility, viscosity, drug content, and in vitro drug release. Results: Acid-activated resins comprising Indion 204, Indion 234, and Tulsion 335 with the drug:resin ratio of 1:2, stirred in a solution of pH 7–8 at 70° for 6 h had a maximum drug loading and masked the bitter taste of clarithromycin. DSC of the drug-resin complex (DRC) revealed that there was interaction leading to complex formation. The drug-resin complex was formulated into suspension formulations (S1-S9) and evaluated. Various parameters were found to be within permissible limits. Formulations S3, S6, and S9 containing 1:2 ratios of the drug-resin complex of Indion 204, Indion 234, and Tulsion 335 revealed maximum taste masking. This was further confirmed by treatment of taste evaluation scores obtained from the volunteers by ANOVA, Dunnett’s multiple comparison test, and Tukey’s multiple comparison test. All the three optimized formulations had a significant difference of p<0.001 when compared to control S10. S6 formulation was widely accepted. Conclusion: Ion-exchange complexation could efficiently mask the bitter taste of clarithromycin and achieve palatable taste suitable for pediatric use.

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“…US Patent 5,024,997 describes taste masking of ibuprofen using hydroxypropyl-beta-cyclodextrin in a palatable solution formulation [57] . Taste masked formulations containing IER complexes of ambroxol [58] , ciprofloxacin [59,60] , levofloxacin [61] , metoclopramide [62] , metformin [63] , ondansetron [64] and risperidone [65] was evaluated. US Patent 5,980,882 describes sustained release drugresin complexes of dextromethorphan coated with ethyl cellulose and stabilized by EDTA as a chelating agent [66] .…”

Section: Taste Masking Technologiesmentioning

confidence: 99%

Solid Oral Flexible Formulations for Pediatric and Geriatric patients: Age-appropriate Formulation Platforms

Ch¹,

rasekaran²,

Ruckmani³

et al. 2018

pharmaceutical-sciences

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Chandrasekaran and Kandasamy: Solid Oral Flexible Formulation Platform for Paediatrics and Geriatrics The oral route of drug administration is mostly preferred by paediatric and geriatric patients. Patient non-compliance due to poor taste and swallowing problems are major issues in paediatric and geriatric drug therapy. Lack of age-appropriate formulations, inadequate labelling instructions, non-compatible and non-palatable medicines are the main reasons for medication errors in paediatric patients. This review mainly highlights major issues of paediatric and geriatric drug therapy and provides the design of oral flexible formulations as an alternative formulation design for age appropriate formulation development. Development of solid oral flexible formulations as an alternative to existing marketed formulations such as conventional tablets, orally disintegrating tablets, chewable and dispersible tablets for paediatric and geriatrics patients is described. Details about drug properties, excipient selection and taste masking approaches were described. The need for bioavailability and bioequivalence studies for flexible formulations also described. Development of flexible formulations as an alternative to marketed different formulations of the same drug would reduce the cost of the formulation for patients particularly developing countries where accessibility to various types of formulations is less. Flexible tablet formulations can be conveniently used by the patients as orally swallowable, orally disintegrating, chewable and as dispersible tablets. Sprinkle formulations such as pellets, granules packed in capsules or sachets can be conveniently used by paediatric and geriatric patients. Properly designed and developed flexible formulations for new chemical entities and off-patent drugs are need of the hour to provide better treatment to varying age groups of paediatrics and geriatrics.

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Comparative study of ion-exchange resin Indion 204 and Indion 214 for the taste masking of metoclopramide hydrochloride and formulation of rapid-disintegrating tablets

Cited by 4 publications

References 8 publications

Variables affecting sulfasalazine - ion exchange resin complexation

Variables affecting sulfasalazine - ion exchange resin complexation

Design, Optimization, and Statistical Evaluation of Oral Reconstituted Suspension of Clarithromycin Using Ion-Exchange Resins

Solid Oral Flexible Formulations for Pediatric and Geriatric patients: Age-appropriate Formulation Platforms

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