Comparative study of intranasal hypertonic seawater saline versus intranasal normal saline in allergic rhinitis

Singh, Roohie; Galagali, J. R.; Kumar, Santosh; Bahurupi, Yogesh; Chandrachood, Mandar V.

doi:10.18203/issn.2454-5929.ijohns20164810

Cited by 2 publications

(5 citation statements)

References 9 publications

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“…Of the 23 studies that assessed the effects of nasal saline treatment in patients with AR, 19 were RCTs and 4 were meta-analyses. Eleven RCTs assessed adult AR, 4 - 14 and 8 RCTs assessed pediatric AR. 15 - 22 Three meta-analyses pooled the data from adult and pediatric AR, 1 , 3 , 23 and 1 meta-analysis examined data only from children.…”

Section: Resultsmentioning

confidence: 99%

“…12 Spray was effective when compared with baseline. 9 , 10 Yet, there were no comparisons between spray and other devices.…”

Section: Resultsmentioning

confidence: 99%

“…In adult AR, 5 RCTs compared hypertonic saline (range, 1.8%‐3%) and isotonic saline 4,5,9,11,14 . Symptom reduction and QoL improvement favored the hypertonic solution at the duration of 1 to 8 weeks 5,9,11 .…”

Section: Resultsmentioning

confidence: 99%

“…In adult AR, 5 RCTs compared hypertonic saline (range, 1.8%-3%) and isotonic saline. 4,5,9,11,14 Symptom reduction and QoL improvement favored the hypertonic solution at the duration of 1 to 8 weeks. 5,9,11 Three metaanalyses with a mixed population of adults and children reported greater benefits of hypertonic saline.…”

Section: Rhinitismentioning

confidence: 99%

“…4,5,9,11,14 Symptom reduction and QoL improvement favored the hypertonic solution at the duration of 1 to 8 weeks. 5,9,11 Three metaanalyses with a mixed population of adults and children reported greater benefits of hypertonic saline. 1,3,23 Isotonic saline shortened the saccharin transit time (STT), but hypertonic saline did not.…”

Section: Rhinitismentioning

confidence: 99%

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Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review

et al. 2022

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Objective This review aimed to systematically determine the optimal nasal saline regimen for different types of sinonasal diseases. Data Sources PubMed, Embase, SCOPUS, Cochrane Library, Web of Science, ClinicalTrials.gov. The last search was on December 6, 2021. Review Methods Study selection was done by 2 independent authors. Randomized controlled trials and meta-analyses were included. The effects of nasal saline treatment through various devices, saline tonicities, and buffer statuses were evaluated in patients with allergic and nonallergic rhinitis, acute and chronic rhinosinusitis (CRS), CRS with cystic fibrosis, and postoperative care, including septoplasty/turbinoplasty and endoscopic sinus surgery. Results Sixty-nine studies were included: 10 meta-analyses and 59 randomized controlled trials. For allergic rhinitis, large-volume devices (≥60 mL) were effective for treating adults, while low-volume devices (5-59 mL) were effective for children. Isotonic saline was preferred over hypertonic saline due to fewer adverse events. For acute rhinosinusitis, saline irrigation was beneficial in children, but it was an option for adults. Large-volume devices were more effective, especially in the common cold subgroup. For CRS, large-volume devices were effective for adults, but saline drop was the only regimen that had available data in children. Buffered isotonic saline was more tolerable than nonbuffered or hypertonic saline. The data for CRS with cystic fibrosis and nonallergic rhinitis were limited. For postoperative care, buffered isotonic saline delivered by large-volume devices was effective. Conclusion Nasal saline treatment is recommended for treating most sinonasal diseases. Optimal delivery methods for each condition should be considered to achieve therapeutic effects of saline treatment.

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Section: Resultsmentioning

confidence: 99%

“…12 Spray was effective when compared with baseline. 9 , 10 Yet, there were no comparisons between spray and other devices.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Rhinitismentioning

confidence: 99%

Section: Rhinitismentioning

confidence: 99%

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Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review

et al. 2022

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Saline irrigation for allergic rhinitis

Head

Snidvongs

Glew

et al. 2018

Cochrane Database of Systematic Reviews

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Background Allergic rhinitis is a common condition affecting both adults and children. Patients experience symptoms of nasal obstruction, rhinorrhoea, sneezing and nasal itching, which may affect their quality of life. Nasal irrigation with saline (salty water), also known as nasal douching, washing or lavage, is a procedure that rinses the nasal cavity with isotonic or hypertonic saline solutions. It can be performed with low positive pressure from a spray, pump or squirt bottle, with a nebuliser or with gravity-based pressure in which the person instils saline into one nostril and allows it to drain out of the other. Saline solutions are available over the counter and can be used alone or as an adjunct to other therapies. Objectives To evaluate the effects of nasal saline irrigation in people with allergic rhinitis. Search methods The Cochrane ENT Information Specialist searched the ENT Trials Register; CENTRAL; Ovid MEDLINE; Ovid Embase; CINAHL; Web of Science; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 23 November 2017. Selection criteria Randomised controlled trials (RCTs) comparing nasal saline irrigation, delivered by any means and with any volume, tonicity and alkalinity, with (a) no nasal saline irrigation or (b) other pharmacological treatments in adults and children with allergic rhinitis. We included studies comparing nasal saline versus no saline, where all participants also received pharmacological treatment (intranasal corticosteroids or oral antihistamines). Data collection and analysis We used the standard methodological procedures expected by Cochrane. Primary outcomes were patient-reported disease severity and a common adverse effect-epistaxis. Secondary outcomes were disease-specific health-related quality of life (HRQL), individual symptom scores, general HRQL, the adverse effects of local irritation or discomfort, ear symptoms (pain or pressure) and nasal endoscopy scores. We used GRADE to assess the quality of the evidence for each outcome; this is indicated in italics.

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Comparative study of intranasal hypertonic seawater saline versus intranasal normal saline in allergic rhinitis

Cited by 2 publications

References 9 publications

Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review

Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review

Saline irrigation for allergic rhinitis

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