Comparative study of in vitro antioxidant and anti-inflammatory potentials of two malvaceae used in folk medicine in Burkina Faso

Coulidiati, Tangbadioa Hervé; Thiombiano, Emmanuel A. M.; Bangou, Mindiédiba Jean; Sombié, Pierre Alexandre Eric Djifaby; Kiendrebéogo, Martin

doi:10.15406/ijcam.2019.12.00478

Cited by 2 publications

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“…Quantification of the polyphenolic compounds revealed that (i) phenolics were abundant in W. rostrata and (ii) flavonoids and condensed and hydrolyzable tannins were found to be rich in H. panduriformis. The results are consistent with previous reports [12,28] regarding the total phenol content in W. rostrata. Polyphenol compounds present in Alternanthera pungens were mostly phenolic compounds, confirming other studies [10,29].…”

Section: Discussionsupporting

confidence: 93%

“…The results are consistent with other authors that have reported the anti-inflammatory activity, especially the antilipoxygenase activity of the Malvaceae family [28,33,34] and some species from the genus Alternanthera (Amaranthaceae) [10]. For instance, the ethanolic, hydroacetonic, and aqueous extracts of W. amplissima also developed a moderate (IC 50 < 100 μg/mL) inhibitory activity of lipoxygenase enzyme [28]. To the best of our knowledge, this is the first report about the antilipoxygenase activity of Hibiscus panduriformis and Alternanthera pungens.…”

Section: Discussionsupporting

confidence: 93%

“…Among the investigated extracts of each plant, the best LOX inhibition was obtained with the methanolic extract of H. panduriformis, n-Hexane extract of A. pungens, and DCM extract of W. rostrata. The results are consistent with other authors that have reported the anti-inflammatory activity, especially the antilipoxygenase activity of the Malvaceae family [28,33,34] and some species from the genus Alternanthera (Amaranthaceae) [10]. For instance, the ethanolic, hydroacetonic, and aqueous extracts of W. amplissima also developed a moderate (IC 50 < 100 μg/mL) inhibitory activity of lipoxygenase enzyme [28].…”

Section: Discussionsupporting

confidence: 92%

“…Although there are no reports on the pharmacological investigations of H. panduriformis, antioxidant activity has been reported on other Hibiscus species [39,40]. Although weak, the DPPH scavenging effect of the ethyl acetate and methanolic extracts of A. pungens and W. rostrata was comparable to that of other previous reports [12,28,29]. The DPPH radical scavenging activity could have been underestimated.…”

Section: Discussionmentioning

confidence: 65%

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Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

Rainatou,

Esther,

Boukaré

et al. 2023

BioMed Research International

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The present study investigated the phytochemical content of Hibiscus panduriformis, Alternanthera pungens, and Wissadula rostrata and assessed their radical scavenging and anti-inflammatory properties. n-Hexane, dichloromethane (DCM), ethyl acetate, and methanol extracts were prepared from the powdered plant parts. The phytochemical analysis was performed using qualitative high-performance thin-layer chromatography, and polyphenols were quantified using well-established methods. The anti-inflammatory effect was by lipoxygenase inhibition, while the antiradical impact was evaluated through DPPH and ABTS radicals. Steroids, triterpenoids, flavonoids, and tannins were identified in the three plants. The highest phenolic content (95.67±2.19 mg gallic acid equivalent/g) was obtained in the methanolic extract of W. rostrata, while the lowest was measured in H. panduriformis. H. panduriformis was found to be highly rich in flavonoids (61.22±0.09 mg rutin equivalent/g), condensed tannins (62.53±0.03 mg catechin equivalent/g), and hydrolyzable tannins (125.1±1.02 mg tannic acid equivalent/g). The methanolic extract of H. panduriformis displayed the greatest antilipoxygenase activity with an IC50 value of 8.78±1.05 μg/mL. It should be noted that although a moderate to low effect was observed, the extracts were more likely to scavenge DPPH (IC50 values ranged from 0.106±0.010 to 1 mg/mL) than ABTS radicals. There was a strong to moderate correlation between the antilipoxygenase and DPPH radical scavenging effects of the methanolic extracts and total phenolic content (antilipoxygenase, r=0.7175; DPPH, r=0.9376). Furthermore, it is worth noting that this is the first report investigating the phytochemical analysis and in vitro biological properties of Hibiscus panduriformis. The results highlighted the richness of this plant in polyphenols and demonstrated its high and moderate effects on lipoxygenase and DPPH radicals, respectively. To this intent, further in vivo and in vitro studies on this plant, along with exhaustive phytochemical analysis, are needed.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 65%

See 2 more Smart Citations

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

Rainatou,

Esther,

Boukaré

et al. 2023

BioMed Research International

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Phytochemical, Antioxidant and Anti-Inflammatory Effects of Extracts from Ampelocissus africana (Lour) Merr (Vitaceae) Rhizomes

Kabré

Ouédraogo

Coulibaly

et al. 2020

JPRI

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Aims: To determine the phytochemical composition and evaluate the antioxidant and anti-inflammatory properties of methanolic and aqueous extracts from Ampelocissus africana (Lour) Merr rhizomes. Study Design: Phytochemical content and screening, in vitro antioxidant and anti-inflammatory assays. Place and Duration of Study: Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and Laboratory of Applied Biochemistry and Chemistry (LABIOCA), University Joseph KI-ZERBO in Ouagadougou between April and August 2020. Methodology: The antioxidant activity of both extracts of the plant was assessed using DPPH radical scavenging, ABTS+ radical cation decolorization, ferric ion reduction and lipid peroxidation inhibition in rat liver assays. The anti-inflammatory activities in vitro were measured on the ability of the extract to inhibit the activity of enzymes such as 15-lipoxygenase, phospholipase A2 (PLA2) and cyclooxygenases (COX-1 and COX-2). Results: This study revealed that the total phenolic contents of the extracts varied from 471.79 ± 1.71 mg GAE/g to 173.88 ± 1.71 mg GAE/g for methanolic and aqueous extract respectively. The extracts were also rich in flavonoids and tannins. The methanolic extract possessed better antioxidant activity with an IC50 of 2.32 ± 0.18 µg/ml for the ABTS, 1.71 ± 0.05 µg/mL for the DPPH, a reducing power agent of 87.44 ± 0.5 mmol AAE /100 g and a percentage inhibition of lipid peroxidation of 52.21%. The methanolic and aqueous extract of A. africana has an inhibitory action on activity of lipoxygenase with IC50 values of 26.09 ± 1.83 μg/mL to 34.32 ± 1.60 μg/mL, respectively. The methanolic extract caused COX-1 inhibition of 36.07%, COX-2 inhibition of 38.31% and PLA2 inhibition of 26.9%. Conclusion: These results showed that the methanolic and aqueous extract from the rhizomes of Ampelocissus africana possessed antioxidant power, inhibitor effect against proinflammatory enzymes.

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Comparative study of in vitro antioxidant and anti-inflammatory potentials of two malvaceae used in folk medicine in Burkina Faso

Cited by 2 publications

References 0 publications

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

Phytochemical, Antioxidant and Anti-Inflammatory Effects of Extracts from Ampelocissus africana (Lour) Merr (Vitaceae) Rhizomes

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