Comparative study of hydroxyapatite, fluor-hydroxyapatite and Si-substituted hydroxyapatite nanoparticles on osteogenic, osteoclastic and antibacterial ability

Abstract

This study compared the effects of hydroxyapatite (HA), fluor-hydroxyapatite (FHA) and Si-substituted hydroxyapatite (SiHA) on osteogenic differentiation, osteoclastic activity and antibacterial properties.

Hydrothermal Synthesis of Fluorapatite Coatings over Titanium Implants for Enhanced Osseointegration—An In Vivo Study in the Rabbit

“…It can be observed that all characteristic peaks of fluorapatite, P2p, and Ca2p, at 133.2 and 347.2 eV, respectively [ 30 ], were detected in the F 0.1 coating. Looking in detail, it can be observed one additional small peak at ~684.3 eV, belonging to F1s, indicating that F − ions were incorporated into the fluorapatite lattice structure [ 31 , 32 ]. The F/Ca ratio, calculated directly from the XPS data, was F/Ca = 0.182.…”

Modification of the crystallographic parameters in a biomaterial employing a series of gamma radiation doses

“…23 Thus, variation in the crystallite size significantly influences the properties of the materials. To measure the crystallite size, the data of XRD are widely utilized, and Scherrer's equation is generally used 24 which is expressed here in eqn (2), and the computed crystallite sizes are documented in Table 2. When highenergy gamma radiation was applied through the HAp samples, there was a linear change of crystallite sizes within the 20-80 kGy gamma radiation doses.…”

“…2 It is being widely used as a potential bone graft substitute material in orthopedic and dentistry fields, 3 and thus controlling its properties is very crucial for fruitful applications, notably 2.2 million people need bone grafting per year. 2 Crystallite size and shape are important for the biomimetic application of materials in the body along with controlling degradation properties. 4 In addition to the biomedical application, HAp has been widely used in various fields such as wastewater treatment, 5 therapeutic ion delivery, 6 photocatalytic degradation, 7 etc.…”

“…There has been emerging interest in hydroxyapatite (HAp) due to its morphology, crystallinity, and chemical composition which are very similar to those of human hard tissue, 1 60–70% of which is composed of this biomaterial. 2 It is being widely used as a potential bone graft substitute material in orthopedic and dentistry fields, 3 and thus controlling its properties is very crucial for fruitful applications, notably 2.2 million people need bone grafting per year. 2 Crystallite size and shape are important for the biomimetic application of materials in the body along with controlling degradation properties.…”

Biyo–Seramik Bileşimine Silisyum Katkısının Osteokondüktif ve Osteoindüktif Özelliklere Etkisi

“…Bu çalışmada SiHA için % 1,63 ağırlıkça Si ilavesi yapılmıştır. Oranın fazla olduğu çünkü elektro-kimyasal kaplama ile sağlanan 3 boyutlu yüzeyin fazla Si birikimine yol açtığı ve bunun da sitotoksisiteye neden olduğu düşünülmektedir[135][136].HA yüksek biyo-uyumluluğu ve osteokondüktif özelliği sayesinde klinik uygulamalarda tercih edilen bir biyo-seramik malzemedir. Fakat stokiyometrik HA, yeni kemik dokusunun gelişimini teşvik etmek ve ara yüzler oluşturmak için sınırlı bir yeteneğe sahiptir.…”