Comparative study of head and neck mucosal melanoma in 66 patients vs 226 patients with cutaneous melanoma: A survival analysis

Luna-Ortiz, Kuauhyama; Villavicencio-Valencia, Verónica; Saíd, Héctor Martínez

doi:10.1111/coa.13000

Cited by 4 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The poor prognosis of patients with mucosal melanomas and their ineffective treatment options evidence that these tumours have a distinct biological signature, which is different from the other subtypes of melanomas [5, 10, 19]. Although some studies have extensively addressed the clinicopathological profile of the mucosal melanomas and their immunoprofile, these tumours have lacked predictive markers for tailored treatment [20–24].…”

Section: Discussionmentioning

confidence: 99%

“…Overall, the treatment of choice for both mucosal and cutaneous melanoma is the wide surgical resection [50–52]. Although it has been demonstrated that melanomas are not radiosensitive, some tumours have been treated with adjuvant radiotherapy, and the use of these combined therapies are not standardized [10]. Regarding the mucosal melanomas, approximately 30% of the patients from the sample with oral melanomas and 50% of the patients with sinonasal melanomas received chemotherapy or radiotherapy as adjuvant treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Sinonasal melanomas in some series have presented a high-mortality index (near 100%) [8, 9]. Clinicopathological parameters determine the prognosis and staging of the melanomas from different anatomic sites [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas

Soares

Morais

Carlos³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (P < .0001), oral (P < .0001), and sinonasal (P = .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (P = .041) and sinonasal (P < .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.

show abstract