Comparative Study of Growth Hormone Treatment in Children with Idiopathic Short Stature and Growth Hormone Deficiency

Abstract

GH treatment was effective in both children with ISS and those with GHD. Early intervention with GH is the most appropriate therapeutic option in both ISS and GHD.

Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height

“…Finally, it should be noted that in the area of treated idiopathic short stature, the majority are non-randomized studies that involved 2–10 years of monitoring, with samples ranging from 22 to 655 children; these studies were more heterogeneous (both sexes) and had more consistent results than the groups of idiopathic short stature found in our study, although similar results were obtained [ 16 , 19 , 20 , 21 , 24 , 25 , 28 , 29 ]. Instead, our results were influenced by the fact that we added a comparison with GHD, and that we were probably treating ISS patients under the misdiagnosis of GHD.…”

“…In our study, children with ISS (Group B) showed a GH treatment response that was not different to children with GH deficiencies (Group A). Similarly, some groups revealed that the response to treatment was independent of the etiology of short stature [ 19 , 20 , 21 ]. The results of the National Cooperative Growth Study (NCGS), comparing 1186 children with treated ISS and 1899 children with treated GH deficiency, likewise showed similar behavior in both groups.…”

Differences in Response to Recombinant Growth Hormone Therapy on Height Gain in Patients with Idiopathic Short Stature Vs. Patients with Growth Hormone Deficiency

“…However, the use of this medication in ISS might result in a rapid increase in bone age and early closure of the epiphyseal plate, which could eventually affect these patients' ability to attain expected adult height [9][10][11][12][13]. In contrast, many published research papers documented the efficacy of using rhGH in increasing the expected final adult height and growth velocity in patients with ISS [14][15][16][17][18][19][20][21][22][23][24]. In our study, we aimed mainly to compare the effect on height in patients with GHD and ISS after one year of treatment with rhGH.…”

Response to growth hormone according to provocation test results in idiopathic short stature and idiopathic growth hormone deficiency

“…The results of previous studies have been controversial in this regard. Several studies have reported similar growth responses between the ISS and GHD groups [ 17 - 19 ]. However, Kim et al [ 20 ] reported that ∆HtSDS in patients with idiopathic GHD was significantly higher than that in patients with ISS.…”