Comparative study of glutamate dehydrogenase in the brain of patients with schizophrenia and mentally healthy people

Abstract

GDH enzymatic activity was significantly increased in the prefrontal cortex (area 10) (p<0.004), the posterior cingulate cortex (area 23) (p<0.05) and the cerebellar cortex (p<0.002) and was unchanged in the anterior cingulate cortex (area 24) in patients with schizophrenia compared to controls. The levels of immunoreactive GDH I, GDH II and GDH III were significantly higher in the prefrontal cortex of patients with schizophrenia than in controls (p<0.008, p<0.003, and p<0.0001, respectively). Levels of all three immunoreactive GDH forms were unchanged in the anterior cingulate cortex (area 24), but they were increased in the posterior cingulate cortex (area 23) (p<0.004, p<0.001 and p<0.02, respectively). The levels of immunoreactive GDH II and GDH III, but not GDH I, were significantly increased in the cerebellar cortex of patients with schizophrenia compared with the control group (p<0.02 and p<0.001, respectively). The alteration in the levels of GDH immunoreactive forms in the brain of patients with schizophrenia is one of the causes of impaired brain glutamate metabolism and an important aspect of schizophrenia pathogenesis.

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“…GDH enzymatic activity was also significantly increased in the prefrontal cortex, posterior cingulate cortex and cerebellar cortex in patients with schizophrenia compared with controls. According to Tereshkin et al, the alterations in the levels of immunoreactive forms of GDH in the brains of patients with schizophrenia is one of the causes of impaired glutamate metabolism in the brain and an important aspect of the pathogenesis of schizophrenia [209]. Altered levels of GDH, among other things, in the brains of patients with schizophrenia is one of the causes of impaired glutamate metabolism in these brain structures and an important aspect of the pathogenesis of schizophrenia [210].…”