Comparative study of genotype B and C hepatitis B virus‐induced chronic hepatitis in relation to the basic core promoter and precore mutations

Abstract

Genotype B patients were older, had earlier HBeAg seroconversion and exhibited more severe lobular necroinflammation, less portal inflammation and fibrosis than genotype C patients. This genotypic difference is related to the basic core promoter and precore mutations irrespective of 1858C. (c) 2004 Blackwell Publishing Asia Pty Ltd.

The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B

“…These studies included between 90 and 4,841 patients followed up for up to 14 years [33,[38][39][40][41][42]. They confirmed that HBeAg seroconversion occurred at a significantly younger age for those infected with genotype B than genotype C [15,38,40,42] and that increased risk of fibrosis was associated with genotype C [39,40].…”

“…Ideally, these investigations should be population-based studies that compare persons with different genotypes, conducted prospectively over a long period of time to precisely identify the risk of sequelae associated with each genotype and subgenotype, such as have been done in Asia and Alaska [15,21,33,[38][39][40][41][42]. At this time, several HBV genotypes and subgenotypes, such as genotypes A1 and D, that have been associated with increased risk of cirrhosis and HCC in cross-sectional studies have not been evaluated in prospective longitudinal studies.…”

“…These studies included between 90 and 4,841 patients followed up for up to 14 years [33,[38][39][40][41][42]. They confirmed that HBeAg seroconversion occurred at a significantly younger age for those infected with genotype B than genotype C [15,38,40,42] and that increased risk of fibrosis was associated with genotype C [39,40]. The two largest studies, consisting of 426 and 4,841 patients followed up for a mean of 4.8 and 14 years, respectively, showed a significant increase in risk for HCC in genotype C in comparison with genotype B [33,[38][39][40][41][42].…”

Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

“…The genotypes of HBV show a distinct geographic distribution 10,11 and are associated with different clinical outcomes, responses to treatment with interferon or nucleotide analogues, and rates of fulminant hepatitis. [12][13][14][15][16][17][18][19][20][21] Historically, 96.9% of HBV isolates from Japanese individuals with chronic hepatitis B belong to genotypes B or C 14 ; however, since 2000, HBV/A has spread in urban areas through homosexual intercourse. 18,[21][22][23] The positivity rate for HBV infection in Japanese HIV-1-infected individuals is 8.9%, and half of HBV-infected individuals harbor the genotype A virus.…”

Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients

“…HBV is classified into 8 genotypes (A-H), each showing a distinct geographical distribution and disease progression. HBV genotype C is believed to be associated with a higher risk of reactivation and progression to cirrhosis compared to HBV genotype B [22,23] . Whether hepatitis B virus (HBV) genotypes influence the response to antiviral treatment remains controversial.…”