Comparative Study of Four Different Spherical Embolic Particles in an Animal Model: A Morphologic and Histologic Evaluation

Bilbao, J.I.; Luis, Esther de; Jalón, J. A. García de; Martino, Alba De; Lozano, Marı́a D.; Cuesta, Antonio Martínez de la; Sangro, Bruno

doi:10.1016/j.jvir.2008.07.014

Cited by 55 publications

(32 citation statements)

References 29 publications

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“…13 Another frequent reason for recanalization is extravasation of the embolic material due to vessel wall destruction. This mechanism has been described in previous reports, including embolization of human AVMs with cyanoacrylates 25 or polyvinyl alcohol particles, 26 and embolization of the animal kidney 14,27 or uterus 20 with polyvinyl alcohol particles and various microspheres. Because no vessel wall damage was observed in our study, this also contributes to the observed results.…”

Section: Recanalizationmentioning

confidence: 54%

“…Because no signs of bacterial colonization were noted, the intraluminal and perivascular inflammation might be due to the toxic effects of ischemia and the embolic material itself. 15,27 In our experiment, the inflammatory changes may partly result from the ischemic effect of the embolization of the kidney that has a terminal circulation without collateral vascular supply. Embolization could produce an ischemic necrosis of kidney tissue that induced various degrees of inflammation reactions trying to "clean" the damaged tissue.…”

Section: Inflammation Reactionsmentioning

confidence: 74%

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Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Zhao¹,

Zheng²,

Gao³

et al. 2012

AJNR Am J Neuroradiol

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Section: Recanalizationmentioning

confidence: 54%

Section: Inflammation Reactionsmentioning

confidence: 74%

Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Zhao¹,

Zheng²,

Gao³

et al. 2012

AJNR Am J Neuroradiol

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“…The localized tissue distribution observed with this product, coupled with its in situ degradation and absorption, suggests that OCL 503 may have a greater safety profile than many approved and marketed embolic devices, which can migrate to nontarget tissue or have been reported to extravasate from the target vasculature [3,14,15]. Additional work is warranted with this device.…”

Section: Discussionmentioning

confidence: 94%

A Preclinical Study of the Safety and Efficacy of Occlusin™ 500 Artificial Embolization Device in Sheep

Owen

Nation

Polakowski³

et al. 2011

Cardiovasc Intervent Radiol

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“…22 With new materials, such as acrylic embospheres and hepaspheres continuously, emerging the preferred agents are likely to change over time. 23 The advantage of a surgical approach includes complete resection of the disease and pathologic analysis of the specimen to confirm the diagnosis. Where imaging strongly supports a diagnosis of AML, surgical treatment with simple enucleation is feasible and may reduce nephron loss.…”

Section: Discussionmentioning

confidence: 99%

Treatment of angiomyolipoma at a tertiary care centre: the decision between surgery and angioembolization

Faddegon

2013

CUAJ

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E138Cite as: Can Urol Assoc J 2011;5(6):E138-E141; http://dx.doi.org/10.5489/cuaj.10028. Epub 2011 Jan 13. AbstractBackground: Angiomyolipoma (AML) is a benign renal neoplasm. First-line therapy includes renal preserving surgery or angioembolization (RAE), both with good outcomes in isolated studies. However, there are no comparative randomized trials and no clinical guidelines to help clinicians decide between these treatment modalities. Our study examines the patterns of AML treatment at a tertiary care centre to evaluate how local urologists have been treating this disease. Methods: This is a retrospective study of all AMLs treated at the Vancouver General Hospital (Vancouver, BC, Canada) over the past 10 years with either RAE or surgical excision. Searches were performed of the radiology and pathology dictation systems, using the following keywords: AML, angiomyolipoma, angioembolization, embolization, surgery, partial nephrectomy and nephrectomy. Results: At our institution, more AMLs were treated by surgery than angioembolization (42 vs. 17 cases). Angioembolization was more often chosen for cases of multifocal AML (35% vs. 7%) and acute hemorrhage (50% vs. 14%). In the angioembolization cases, particles were the embolic agent of choice (used 40% of the time). Conclusions: Angioembolization allows rapid patient stabilization in cases of acute hemorrhage, and provides good renal preservation in cases of multifocal AML. It may also be preferred in large masses when partial nephrectomy is not feasible. Surgery should be performed in cases of diagnostic uncertainty or complex vascular anatomy not amenable to RAE. Prospective randomized studies are needed to compare RAE and surgery to better define their indications in sporadic AML. RésuméContexte : Un angiomyolipome (AML) est une tumeur bénigne du rein. Le traitement de première intention comprend une chirurgie de conservation rénale ou une angioembolisation rénale, qui ont toutes deux donné de bons résultats dans des études isolées. Cependant, aucun essai comparatif randomisé n'a été mené et il n'existe pas de lignes directrices pour aider les cliniciens à choisir entre ces modalités thérapeutiques. Notre étude a examiné les tendances dans le traitement de l'AML à un centre de soins tertiaires pour évaluer comment les urologues y traitent cette maladie.

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Comparative Study of Four Different Spherical Embolic Particles in an Animal Model: A Morphologic and Histologic Evaluation

Cited by 55 publications

References 29 publications

Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

Temperature-Sensitive poly(N-Isopropylacrylamide-Co-Butyl Methylacrylate) Nanogel as an Embolic Agent: Distribution, Durability of Vascular Occlusion, and Inflammatory Reactions in the Renal Artery of Rabbits

A Preclinical Study of the Safety and Efficacy of Occlusin™ 500 Artificial Embolization Device in Sheep

Treatment of angiomyolipoma at a tertiary care centre: the decision between surgery and angioembolization

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