Comparative Study of Food Allergies in Children from China, India, and Russia: The EuroPrevall-INCO Surveys

Li, Jing; Огородова, Л. М.; Mahesh, P A; Wang, Maggie Haitian; Федорова, О. С.; Leung, Ting Fan; Fernández‐Rivas, Montserrat; Mills, E. N. Clare; Potts, James; Kummeling, Ischa; Versteeg, Serge A.; Ree, Ronald van; Yazdanbakhsh, Maria; Burney, Peter; Wong, Gary

doi:10.1016/j.jaip.2019.11.042

Cited by 73 publications

(128 citation statements)

References 41 publications

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“…Among schoolchildren in southern China, the prevalence rate of doctor-diagnosed crustacean allergy was significantly higher in urbanized Guangzhou (5.1%) than those in the rural Shaoguan (1.8%) [23]. When defined by reported symptoms and positive skin prick test/specific IgE (≥ 0.7 kU/L), shrimp remained as the leading offender in Hong Kong (1.05%), Guangzhou (0.18%) and Shaoguan (0.65%) [24]. In Singapore and the Philippines, 5.2% and 5.1% of teenagers reported a convincing allergic history after shellfish ingestion.…”

Section: Epidemiologymentioning

confidence: 99%

Overcoming Shellfish Allergy: How Far Have We Come?

Wai

Leung

Chu

et al. 2020

IJMS

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Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a “cure “for shellfish allergy is within reach.

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Section: Epidemiologymentioning

confidence: 99%

Overcoming Shellfish Allergy: How Far Have We Come?

Wai

Leung

Chu

et al. 2020

IJMS

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“…In contrast to high income countries, a recently conducted EuroPrevall-INCO survey revealed food allergy to be 0.14% among children from 2 participating Indian centres. 38 Interestingly, sensitisation rate was quite high (19.1%) to food allergens in Indian children in this survey. 38 In other words, despite high sensitisation rates, the prevalence of clinically relevant food allergies was extremely low.…”

Section: Disease Burdenmentioning

confidence: 57%

“… 38 Interestingly, sensitisation rate was quite high (19.1%) to food allergens in Indian children in this survey. 38 In other words, despite high sensitisation rates, the prevalence of clinically relevant food allergies was extremely low. Despite high consumption of peanuts in different foods in India, peanut allergy in children was found to be quite low (0.03%), although peanut sensitisation was high at 6.3%.…”

Section: Disease Burdenmentioning

confidence: 57%

An appraisal of allergic disorders in India and an urgent call for action

Krishna

Mahesh

Vedanthan³

et al. 2020

World Allergy Organization Journal

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India is the second most populous country in the world with a population of nearly 1.3 billion, comprising 20% of the global population. There are an estimated 37.5 million cases of asthma in India, and recent studies have reported a rise in prevalence of allergic rhinitis and asthma. Overall, 40–50% of paediatric asthma cases in India are uncontrolled or severe. Treatment of allergic rhinitis and asthma is sub-optimal in a significant proportion of cases due to multiple factors relating to unaffordability to buy medications, low national gross domestic product, religious beliefs, myths and stigma regarding chronic ailment, illiteracy, lack of allergy specialists, and lack of access to allergen-specific immunotherapy for allergic rhinitis and biologics for severe asthma. High quality allergen extracts for skin tests and adrenaline auto-injectors are currently not available in India. Higher postgraduate specialist training programmes in Allergy and Immunology are also not available. Another major challenge for the vast majority of the Indian population is an unacceptably high level of exposure to particulate matter (PM) 2.5 generated from traffic pollution and use of fossil fuel and biomass fuel and burning of incense sticks and mosquito coils. This review provides an overview of the burden of allergic disorders in India. It appraises current evidence and justifies an urgent need for a strategic multipronged approach to enhance quality of care for allergic disorders. This may include creating an infrastructure for education and training of healthcare professionals and patients and involving regulatory authorities for making essential treatments accessible at subsidised prices. It calls for research into better phenotypic characterisation of allergic disorders, as evidence generated from high income western countries are not directly applicable to India, due to important confounders such as ethnicity, air pollution, high rates of parasitic infestation, and other infections.

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“…In contrast to the high prevalence of rhinitis, asthma, and eczema, food allergy was low at 0·14% among Indian children aged 6-11 years. 5 What are the implications of these data from a public and global health viewpoint? Inhaled and intranasal corticosteroids constitute the mainstay therapies in asthma and rhinitis.…”

Section: The Burden Of Allergic Diseases In the Indian Subcontinent: mentioning

confidence: 99%