Comparative study of fine needle aspiration cytology and histopathology in thyroid nodules at a tertiary care hospital: First report from Somalia

Abdullahi, Ismail Mohamud; Yasin, Nor Abdi; Dırken, Esın Seren; Mohamoud, Abdillahi Mohamed; Güler, İlkay; Adani, Abdulkamil Abdullahi

doi:10.1016/j.asjsur.2022.11.097

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…This rate is lower than what was calculated by several studies. A recent study on patients from Somalia recorded an overall sensitivity, specificity, and accuracy rate of cytological-histological correlation of 91.1%, 96.6%, and 94.9%, respectively [ 18 ], and the study conducted in 2010 on patients who underwent thyroidectomy recorded an accuracy rate of FNAC of 94.5% and a specificity of 97.3% [ 19 ], which is higher than what we report in this study. This may be due to the application of ultrasound guidance for aspiration or using different cytological techniques affecting the accuracy and processing problems.…”

Section: Discussioncontrasting

confidence: 82%

Diagnostic Accuracy of Fine-Needle Aspiration Cytology (FNAC) in Thyroid Nodule Excision Cases

Alzahrani,

Alghamdi

2024

Cureus

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Introduction: Fine needle aspiration cytology (FNAC) for thyroid nodules has a high diagnostic accuracy, according to several studies worldwide. Patients who experienced preoperative FNAC had more optimal surgical treatment than others who did not perform FNAC. Therefore, achieving an accurate FNAC procedure appears to be an important tool for the proper management of thyroid nodules. We aimed to study the accuracy and challenges of the thyroid FNAC diagnostic tool in the Al-Baha region, Kingdom of Saudi Arabia.Methods: The study involves 52 patients with thyroid nodules who underwent preoperative FNAC and postoperative histopathology with the same surgery and pathology team at Al-Baha region in 2022-2023. Results and Conclusion:The mean age of the included patients was 47.7 years, with a female predominance. The diagnostic accuracy was 90%, and the main cause of inaccurate diagnosis was processing challenges, where the majority of cases were taken on the palpation-only technique, a few cases were ultrasoundguided, and the only technique used in the laboratory was conventional smears. The applied interrater reliability Cohen kappa coefficient (κ) for the clinical-histopathological agreement was "moderate agreement". We recommend using and evaluating more cytological techniques in addition to the currently used conventional smears in pathology laboratories to enhance the efficacy of the FNAC diagnosis of thyroid lesions.

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Section: Discussioncontrasting

confidence: 82%

Diagnostic Accuracy of Fine-Needle Aspiration Cytology (FNAC) in Thyroid Nodule Excision Cases

Alzahrani,

Alghamdi

2024

Cureus

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“…In our study the accuracy of FNAC in detection of the thyroid lesions was found to be 95%. It is well compared with the study done by Babu SBK, 13 in which the accuracy was reported as 94%, and another study done by Abdullahi IM et al 27 the accuracy was 94.9%. The diagnostic accuracy of Correlation between FNAC diagnosis and final HPE diagnosis was 91.66% in a study by Gangadhara KS et al 18 The present study showed PPV of 71.43% which was accordance with studies conducted by Gangadhara KS et al 18 and Srilekha Bodepudi et al 26 In our study the NPV was found to be 96.77% which was similar of studies conducted by Gangadhara KS et al 18 and Babu SBK et al 13 In a study by Reddy MR, 25 PPV and NPV of FNAC in the diagnosis of thyroid lesions was evaluated to be 80% and 73%.…”

Section: Cytology and Histopathology Diagnosis Of Medullary And Anapl...supporting

confidence: 71%

Comparative study of fine needle aspiration cytology and histopathology correlation of various thyroid lesions

Doifode,

Adhye,

Surase

et al. 2023

IJPO

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Patients with anterior neck swelling constitute common problems encountered in the clinical practice. In all age groups, including children, thyroid cancer is the most prevalent endocrine system cancer. Initial diagnostic testing using fine needle aspiration cytology (FNAC) has been found to be quick and cost effective. Therefore, it is widely accepted and more thyroid cases are diagnosed at an early stage, but it is associated with pitfalls due to difference in correlations between FNAC and Histopathological Examination (HPE). The purpose of the study is to compare the results of FNAC with histopathological findings in order to evaluate the diagnostic efficacy of FNAC.The present study was performed over a period of two years in a tertiary care center. Included in the study were 100 cases of thyroid nodule, which underwent FNAC and the post-operative specimens of whom were subjected to histopathological examination. The results obtained by FNAC were compared with histopathological findings.Out of the 100 cases taken for the purpose of the study, 92 were benign whereas 8 were malignant. The cytological and histopathological diagnosis correlated with each-other in 89 cases. A partial correlation between the cytological and histopathological diagnoses was found in 5 cases. In 6 cases the FNAC diagnosis was not correlating with histopathological diagnosis. FNAC revealed a sensitivity of 62.50%, a specificity of 97.83%, an accuracy of 95%, a positive predictive value of 71.43% and a negative predictive value of 96.77%.FNAC of thyroid lesions is thus proved to be a simple, cost effective and accurate method to diagnose and to guide the management of palpable thyroid lesions Thus, we can see that the diagnostic accuracy of FNAC procedure is very high making it a very useful investigation in the work-up of thyroid patients. However final diagnosis and treatment pattern should be based upon histopathology.

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“…As the FNAB is the gold standard for evaluation of thyroid nodules in high resource settings, this method of diagnosis has also gained popularity in LMICs. [36][37][38] As a significant proportion of thyroid nodules represent benign thyroid nodules, FNAB has proved useful in LMICs, particularly in settings where goiter is more common. In one study from Kenya, benign thyroid nodules were accurately distinguished from malignant nodules, while the FNAB was best performed by cytopathologists.…”

Section: Fnab In Thyroid Nodulesmentioning

confidence: 99%

“…As the FNAB is the gold standard for evaluation of thyroid nodules in high resource settings, this method of diagnosis has also gained popularity in LMICs 36–38 . As a significant proportion of thyroid nodules represent benign thyroid nodules, FNAB has proved useful in LMICs, particularly in settings where goiter is more common.…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration biopsy in low‐ and middle‐income countries

Khorsandi,

Balassanian,

Vohra

2024

Diagnostic Cytopathology

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Fine needle aspiration biopsy (FNAB) in low‐ and middle‐income countries (LMIC), can provide minimally invasive, cost‐effective tissue diagnosis with rapid assessment and specimen triage, which is advantageous in these resource‐limited settings. Nevertheless, challenges such as equipment shortages, reagents, and lack of trained personnel exist. This article discusses the effectiveness of FNAB for diagnosis of malignant and inflammatory conditions across various organs, such as lymph nodes, breast, soft tissue, and thyroid and advocates for increased training opportunities and collaboration with academic centers to enhance diagnostic accuracy and access to pathology services.

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Comparative study of fine needle aspiration cytology and histopathology in thyroid nodules at a tertiary care hospital: First report from Somalia

Cited by 4 publications

References 13 publications

Diagnostic Accuracy of Fine-Needle Aspiration Cytology (FNAC) in Thyroid Nodule Excision Cases

Diagnostic Accuracy of Fine-Needle Aspiration Cytology (FNAC) in Thyroid Nodule Excision Cases

Comparative study of fine needle aspiration cytology and histopathology correlation of various thyroid lesions

Fine needle aspiration biopsy in low‐ and middle‐income countries

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