Comparative study of electrospun crystal-based and composite-based drug nano depots

Wang, Ke; Wang, Pu; Wang, Menglong; Yu, Deng‐Guang; Wan, Fuxian; Bligh, S. W. Annie

doi:10.1016/j.msec.2020.110988

Cited by 43 publications

(31 citation statements)

References 64 publications

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“…When the three-layer working fluids are all electrospinnable, the tri-fluid process is a typical triaxial electrospinning, and the products should be tri-layer core–shell fibers [ 68 ]. However, when the outer layer fluid is a pure solvent for lubricating the working process for a high-quality product, the nano products are double-layer core–shell fibers, and the tri-fluid process is a modified triaxial electrospinning [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. The essential meaning is that the outer solvent provides air–solvent and solvent–polymer solution interfaces, instead of a previous air–polymer solution interface, and thus the “dynamic atomization” process is completely modified.…”

Section: Resultsmentioning

confidence: 99%

“…The commercial pH-sensitive copolymer Eudragit S100 (ES100), which has a pH-dependent solubility [ 42 ], was exploited as the polymeric carrier and also the filament-forming matrix. A modified triaxial electrospinning [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] was developed to create the core–shell ES100 nanofibers, in which a drug-free shell layer of ES100 is intentionally coated on a composite aspirin-ES100 core. The monolithic composite nanofibers (MCFs) with aspirin homogeneously distributed all over the ES100 matrix were prepared using a traditional blended electrospinning and were exploited as control.…”

Section: Introductionmentioning

confidence: 99%

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Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

et al. 2020

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In this study, a new modified triaxial electrospinning is implemented to generate an Eudragit S100 (ES100)-based core–shell structural nanofiber (CSF), which is loaded with aspirin. The CSFs have a straight line morphology with a smooth surface, an estimated average diameter of 740 ± 110 nm, and a clear core–shell structure with a shell thickness of 65 nm, as disclosed by the scanning electron microscopy and transmission electron microscopy results. Compared to the monolithic composite nanofibers (MCFs) produced using traditional blended single-fluid electrospinning, aspirin presented in both of them amorously owing to their good compatibility. The CSFs showed considerable advantages over the MCFs in providing the desired drug-controlled-release profiles, although both of them released the drug in an erosion mechanism. The former furnished a longer time period of time-delayed-release and a smaller portion released during the first two-hour acid condition for protecting the stomach membranes, and also showed a longer time period of aspirin-extended-release for avoiding possible drug overdose. The present protocols provide a polymer-based process-nanostructure-performance relationship to optimize the reasonable delivery of aspirin.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

et al. 2020

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“…Although several modified coaxial and triaxial electrospinning processes have been reported based on adjusting the air-fluid contact formats, these processes generally aim to optimize the preparation conditions by employing an additional solvent as a separate working fluid [ 25 , 26 ]. The modified processes have shown great advantages over the traditional processes by enabling the manipulation of the solidification rate of polymeric fluid, which, in turn, generates nanofibers with high quality [ 27 , 28 ]. However, they should inevitably increase the consumption of electrostatic energy, which is neglected in both modified and traditional electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

et al. 2020

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Although electrospun nanofibers are expanding their potential commercial applications in various fields, the issue of energy savings, which are important for cost reduction and technological feasibility, has received little attention to date. In this study, a concentric spinneret with a solid Teflon-core rod was developed to implement an energy-saving electrospinning process. Ketoprofen and polyvinylpyrrolidone (PVP) were used as a model of a poorly water-soluble drug and a filament-forming matrix, respectively, to obtain nanofibrous films via traditional tube-based electrospinning and the proposed solid rod-based electrospinning method. The functional performances of the films were compared through in vitro drug dissolution experiments and ex vivo sublingual drug permeation tests. Results demonstrated that both types of nanofibrous films do not significantly differ in terms of medical applications. However, the new process required only 53.9% of the energy consumed by the traditional method. This achievement was realized by the introduction of several engineering improvements based on applied surface modifications, such as a less energy dispersive air-epoxy resin surface of the spinneret, a free liquid guiding without backward capillary force of the Teflon-core rod, and a smaller fluid–Teflon adhesive force. Other non-conductive materials could be explored to develop new spinnerets offering good engineering control and energy savings to obtain low-cost electrospun polymeric nanofibers.

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“…During the past decade, the traditional single-fluid electrospinning has been quickly shifting to multifluid working processes for creating nanofibers and nanocomposites with complex structural characteristics [ 28 , 29 , 30 , 31 ]. For successful multifluid electrospinning, reasonable selections of working parameters such as flow rates, voltage, and collection distance are important, as in the traditional single-fluid blending electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Multiple-Chamber Nanostructure and Its Potential Self-Healing Applications

Liu

et al. 2020

Polymers

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To address the life span of materials in the process of daily use, new types of structural nanofibers, fabricated by multifluid electrospinning to encapsulate both epoxy resin and amine curing agent, were embedded into an epoxy matrix to provide it with self-healing ability. The nanofibers, which have a polyacrylonitrile sheath holding two separate cores, had an average diameter of 300 ± 140 nm with a uniform size distribution. The prepared fibers had a linear morphology with a clear three-chamber inner structure, as verified by scanning electron microscope and transmission electron microscope images. The two core sections were composed of epoxy and amine curing agents, respectively, as demonstrated under the synergistic characterization of Fourier transform infrared spectroscopy, thermogravimetric analysis (TGA), and differential scanning calorimetry. The TGA results disclosed that the core-shell nanofibers contained 9.06% triethylenetetramine and 20.71% cured epoxy. In the electrochemical corrosion experiment, self-healing coatings exhibited an effective anti-corrosion effect, unlike the composite without nanofibers. This complex nanostructure was proven to be an effective nanoreactor, which is useful to encapsulate reactive fluids. This engineering process by multiple-fluid electrospinning is the first time to prove that this special multiple-chamber structure has great potential in the field of self-healing.

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Comparative study of electrospun crystal-based and composite-based drug nano depots

Cited by 43 publications

References 64 publications

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers

Electrospun Multiple-Chamber Nanostructure and Its Potential Self-Healing Applications

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