Comparative study of different interventional therapies for primary liver cancer

Abstract

AIM:To compare the therapeutic effect of three types of interventional management for primary liver cancer. METHODS:A total of 468 patients with primary liver cancer were randomly allocated to the following three groups: 138 cases treated with chemotherapy alone using mitomycin C, adriamycin and 5-FU (group A); 158 cases treated with chemoembolization using lipiodol (group B); and 172 cases with chemoembolization using lipiodol and gelfoam (group C). All patients were angiographically and sonographically followed-up. RESULTS:In group C, 67.5% patients had AFP value decreased by > 50%, which was much higher than the 43.3% in group B and 32.2% in group A. Tumor size reduction by ≥ 50% occurred in 20.3% of patients in group A, 41.2% of patients in group B and 44.8% of patients in group C. The intergroup differences between group A and group B or C were significant (P < 0.01). The 1-year and 3-year survival rates were 20.5% ± 3.6% and 1.9% ± 2.4% for group A, 51.3% ± 4.4% and 10.1% ± 4.9% for group B, and 63.0% ± 2.4% and 13.9% ± 5.0% for group C, respectively. The differences between all three groups were significant (P < 0.05). The mean survival time for patients in groups A, B and C were 9.6 mo, 16.1 mo and 17.9 mo, respectively. CONCLUSION:Chemoembolization with lipiodol and gelfoam was the most effective therapy for primary liver cancer in this study. The position of the embolization should be far and middle sections of the hepatic artery, and the proximal section should be reserved as the route of the next intra-arterial chemoembolization.

Hepatic Resection after Initial Transarterial Chemoembolization Versus Transarterial Chemoembolization Alone for the Treatment of Hepatocellular Carcinoma: A Meta-analysis of Observational Studies

“…The possible participants should be restricted to the patients at early stage of HCC. However, another two included papers by Eurvilaichit and Liu did not conduct any subgroup analyses (Eurvilaichit and Kanjanapitak, 2000;Liu et al, 2007). Therefore, future studies should confirm the findings in such patients.…”

“…Overall, 2037 papers were initially retrieved, of which 3 were included (Eurvilaichit and Kanjanapitak, 2000;Lee et al, 2002;Liu et al, 2007) (Figure 1). Study characteristics were shown in Table 1.…”

Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus: 2016 edition

“…Lipiodol and gelatin sponge are common embolizing agents used in TACE [ 37 ]. Some reports have suggested that TACE, when combined with lipiodol, is more effective than TAI or conservative treatment [ 22 , 38 ]. The effectiveness of the embolizing agents depends on their size.…”

Basic and Clinical Research on the Therapeutic Effect of Intervention in Primary Liver Cancer by Targeted Intra-Arterial Verapamil Infusion

“…MDR is the main cause for the failure of chemotherapy in the treatment of malignant tumors [13]. Besides, MDR also constitutes one of main reasons as to why the conventional, targeted arterial embolization interventional therapy fails in the chemotherapy of primary hepatocellular carcinoma.…”