Comparative study of cytotoxicity of ferromagnetic nanoparticles and magnetitecontaining polyelectrolyte microcapsules

Минаева, Ольга Владимировна; Brodovskaya, Ekaterina P.; Pyataev, M. A.; Герасимов, М. В.; Zharkov, Mikhail N.; Yurlov, I.A.; Kulikov, Oleg A.; Kotlyarov, A. A.; Балыкова, Л. А.; Kokorev, A. V.; Заборовский, Андрей Владимирович; Pyataev, N. A.; Sukhorukov, Gleb B.

doi:10.1088/1742-6596/784/1/012038

Cited by 18 publications

(19 citation statements)

References 11 publications

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“…The same results were obtained by Minaeva et al . (19). It may suggest that Fe (III) alters membrane stability through ROS production in the way that excess ROS production can cause lipid peroxidation and damage to cell membranes, DNA, and proteins.…”

Section: Discussionmentioning

confidence: 99%

Cell viability in normal fibroblasts and liver cancer cells after treatment with iron (III), nickel (II), and their mixture

Terpiłowska

Siwicka-Gieroba

Siwicki

2018

Journal of Veterinary Research

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IntroductionNickel and iron are very commonly occurring metals. Nickel is used in industry, but nowadays it is also used in medical biomaterials. Iron is an element necessary for cell metabolism and is used in diet supplements and biomaterials, whence it may be released along with nickel.Material and MethodsBALB/3T3 and HepG2 cells were incubated with iron chloride or nickel chloride at concentrations ranging from 100 to 1,400 μM. The following mixtures were used: iron chloride 200 μM plus nickel chloride 1,000 μM, or iron chloride 1,000 μM plus nickel chloride 200 μM. The cell viability was determined with MTT, LHD, and NRU tests.ResultsA decrease in cell viability was observed after incubating the BALB/3T3 and HepG2 cells with iron chloride or nickel chloride. A synergistic effect was observed after iron chloride 1,000 μM plus nickel chloride 200 μM treatment in all assays. Moreover, the same effect was observed in the pair iron chloride 200 μM plus nickel chloride 1,000 μM in the LDH and NRU assays.ConclusionsIron (III) and nickel (II) decrease cell viability. Iron chloride at a concentration of 200 μM protects mitochondria from nickel chloride toxicity.

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Section: Discussionmentioning

confidence: 99%

Cell viability in normal fibroblasts and liver cancer cells after treatment with iron (III), nickel (II), and their mixture

Terpiłowska

Siwicka-Gieroba

Siwicki

2018

Journal of Veterinary Research

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“…When NPs are embedded into the multilayer shell, the translocation, guiding and release of encapsulated cargo from the capsule is enabled by selectively changing the integrity or permeability. Magnetic NPs have shown greater cytotoxicity in comparison with microcapsules containing an equivalent amount of magnetite [79]. The first and foremost way of incorporating NPs into the shell is either by the adsorption of NPs over the sacrificial template or using the NP assembly itself as a template.…”

Section: Nanoparticle Incorporationmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

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“…Although the cytotoxicity of PMs has received considerable attention ( Wattendorf et al, 2008 ; De Koker et al, 2007 ; Minaeva et al, 2017 ), their toxicity at the organism level, interaction with complex living tissues and fate in organisms depending on the route of administration remain poorly reported ( Zhao et al, 2007 ; De Koker et al, 2007 , 2010 ; Sadovoy et al, 2012 ; Yi et al, 2014 ; Shao et al, 2015 ; Voronin et al, 2017 ). Importantly, the most studies report on distribution of microcapsules in certain organs or regions of the body (mostly tumors), and lack analysis of microcapsule behavior on the organism level.…”

Section: Introductionmentioning

confidence: 99%

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

et al. 2018

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The use of polyelectrolyte multilayer microcapsules as carriers for fluorescent molecular probes is a prospective technique for monitoring the physiological characteristics of animal vasculature and interstitial environment in vivo. Polyelectrolyte microcapsules have many features that favor their use as implantable carriers of optical sensors, but little information is available on their interactions with complex living tissues, distribution or residence time following different routes of administration in the body of vertebrates. Using the common fish model, the zebrafish Danio rerio, we studied in vivo the distribution of non-biodegradable microcapsules covered with polyethylene glycol (PEG) over time in the adults and evaluated potential side effects of their delivery into the fish bloodstream and muscles. Fluorescent microcapsules administered into the bloodstream and interstitially (in concentrations that were sufficient for visualization and spectral signal recording) both showed negligible acute toxicity to the fishes during three weeks of observation. The distribution pattern of microcapsules delivered into the bloodstream was stable for at least one week, with microcapsules prevalent in capillaries-rich organs. However, after intramuscular injection, the phagocytosis of the microcapsules by immune cells was manifested, indicating considerable immunogenicity of the microcapsules despite PEG coverage. The long-term negative effects of chronic inflammation were also investigated in fish muscles by histological analysis.

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Comparative study of cytotoxicity of ferromagnetic nanoparticles and magnetitecontaining polyelectrolyte microcapsules

Cited by 18 publications

References 11 publications

Cell viability in normal fibroblasts and liver cancer cells after treatment with iron (III), nickel (II), and their mixture

Cell viability in normal fibroblasts and liver cancer cells after treatment with iron (III), nickel (II), and their mixture

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

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